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Analysis of the typical small watershed of warping dams in the sand properties

Coarse sediment with a particle size greater than 0.05mm is the main deposit of riverbed in the lower Yellow River, the Loess Plateau is one of the concentrated source of coarse sediment, warping dam is one of the important engineering measures for gully control. Jiuyuangou basin is a typical small basin in the first sub region of hilly-gullied loess region, twenty warping dams...

Ownership reform and the changing manufacturing landscape in Chinese cities: The case of Wuxi

Since the economic transition, manufacturing in China has undergone profound changes not only in number of enterprises, but also in ownership structure and intra-urban spatial distribution. Investigating the changing manufacturing landscape from the perspective of ownership structure is critical to a deep understanding of the changing role of market and government in re-shaping...

Pathogenic variant burden in the ExAC database: an empirical approach to evaluating population data for clinical variant interpretation

Background The frequency of a variant in the general population is a key criterion used in the clinical interpretation of sequence variants. With certain exceptions, such as founder mutations, the rarity of a variant is a prerequisite for pathogenicity. However, defining the threshold at which a variant should be considered “too common” is challenging and therefore diagnostic...

Expanded Gene Panel Use for Women With Breast Cancer: Identification and Intervention Beyond Breast Cancer Risk

Yang Karen Ouyang San Francisco Background. Clinicians ordering multi-gene next-generation sequencing panels for hereditary breast cancer risk have a variety of test panel options. Many panels include

A Linguistic Approach to Measuring the Attractiveness of New Products in Portfolio Selection

Ching-Torng Lin 0 Yuan-Shan Yang 0 0 Y.-S. Yang Ph. D Program in Management, Dayeh University, 168 University Rd. , Dacun, Changhua 51591, Taiwan To gain a competitive edge, companies must

New insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey

Hoogsteen (HG) base pairs (bps) provide an alternative pairing geometry to Watson–Crick (WC) bps and can play unique functional roles in duplex DNA. Here, we use structural features unique to HG bps (syn purine base, HG hydrogen bonds and constricted C1′–C1′ distance across the bp) to search for HG bps in X-ray structures of DNA duplexes in the Protein Data Bank. The survey...

Comparative proteomic analysis of a new adaptive Pichia Stipitis strain to furfural, a lignocellulosic inhibitory compound

Xue-Cai Hao 0 Xiu-Shan Yang 0 Ping Wan Shen Tian 0 Equal contributors Enzyme and Fermentation Engineering Laboratory, College of Life Science, Capital Normal University , 105 West Third Circle Road

Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression

Background Improvement of transduction and augmentation of cytotoxicity are crucial for adenoviruses (Ad)-mediated gene therapy for cancer. Down-regulated expression of type 5 Ad (Ad5) receptors on human tumors hampered Ad-mediated transduction. Furthermore, a role of the p53 pathways in cytotoxicity mediated by replication-competent Ad remained uncharacterized. Methods We...

The expression sequence tag is an effective method for screening DNA segments that predict urinary bladder transitional cell carcinoma prognosis

The expression sequence tag is an effective method for screening DNA segments that predict urinary bladder transitional cell carcinoma prognosis Pei-Shan Yang,1,* Yu-Chao Hsu,1,2,* Yu-Hsiang Lin,1,2

Successful management of mucinous ovarian cancer by conservative surgery in week 6 of pregnancy: case report and literature review

Purpose The management of ovarian cancer during pregnancy is still a big challenge, mostly due to the reciprocal impacts between cancer and pregnancy. The objective of this article is to present a rare case of maternal ovarian adenocarcinoma and review published similar cases about this clinical condition. Materials and methods Here we report a rare case of maternal ovarian...

Comparison of the effects of albumin and crystalloid on mortality in adult patients with severe sepsis and septic shock: a meta-analysis of randomized clinical trials

Introduction The aim of this study was to examine whether albumin reduced mortality when employed for the resuscitation of adult patients with severe sepsis and septic shock compared with crystalloid by meta-analysis. Methods We searched for and gathered data from MEDLINE, Elsevier, Cochrane Central Register of Controlled Trials and Web of Science databases. Studies were eligible...

Clinical and pathological correlates of severity classifications in trigger fingers based on computer-aided image analysis

-Hsuan Shih Li-Chieh Kuo Stephen Cha Hsiao-Bai Yang Dee-Shan Yang I-Ming Jou Yung-Nien Sun Fong-Chin Su Background: The treatment of trigger finger so far has heavily relied on clinicians' evaluations

Interferon-β Produces Synergistic Combinatory Anti-Tumor Effects with Cisplatin or Pemetrexed on Mesothelioma Cells

Interferons (IFNs) have been tested for the therapeutic effects in various types of malignancy, but mechanisms of the anti-tumors effects and the differential biological activities among IFN members are dependent on respective cell types. In this study, we examined growth inhibitory activities of type I and III IFNs on 5 kinds of human mesothelioma cells bearing wild-type p53...

In depth comparison of an individual’s DNA and its lymphoblastoid cell line using whole genome sequencing

Background A detailed analysis of whole genomes can be now achieved with next generation sequencing. Epstein Barr Virus (EBV) transformation is a widely used strategy in clinical research to obtain an unlimited source of a subject’s DNA. Although the mechanism of transformation and immortalization by EBV is relatively well known at the transcriptional and proteomic level, the...

Factors Associated with Willingness to Accept Oral Fluid HIV Rapid Testing among Most-at-Risk Populations in China

BackgroundThe availability of oral fluid HIV rapid testing provides an approach that may have the potential to expand HIV testing in China, especially among most-a-risk populations. There are few investigations about the acceptability of oral fluid HIV testing among most-at-risk populations in China. MethodA cross-sectional study with men who have sex with men (MSM), female sex...

A comparative proteomic study identified calreticulin and prohibitin up-regulated in adrenocortical carcinomas

Background Identifying novel tumor biomarkers to develop more effective diagnostic and therapeutic strategies for patients with ACC is urgently needed. The aim of the study was to compare the proteomic profiles between adrenocortical carcinomas (ACC) and normal adrenocortical tissues in order to identify novel potential biomarkers for ACC. Methods The protein samples from 12 ACC...

ShRNA-mediated Ku80 Gene Silencing Inhibits Cell Proliferation and Sensitizes to γ-radiation and Mitomycin C-induced Apoptosis in Esophageal Squamous Cell Carcinoma Lines

Qing-Shan YANG Jin-Long GU Li-Qing DU Li-Li JIA Li-Li QIN Yong WANG Fei-Yue FAN Ku80/shRNA/Proliferation/Apoptosis/Esophageal cancer. To investigate the effects of Ku80 depletion on cell growth and

cAMP/PKA Regulates Osteogenesis, Adipogenesis and Ratio of RANKL/OPG mRNA Expression in Mesenchymal Stem Cells by Suppressing Leptin

BackgroundMesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into adipocytes, osteoblasts and other cells. The reciprocal relationship between adipogenesis and osteogenesis was previously demonstrated; however, the mechanisms remain largely unknown.Methods and FindingsWe report that activation of PKA by 3-isobutyl-1 methyl xanthine (IBMX) and...