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Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection

Background Inhalation of environmental (nano) particles (NP) as well as persistent herpesvirus-infection are potentially associated with chronic lung disease and as both are omnipresent in human society a coincidence of these two factors is highly likely. We hypothesized that NP-exposure of persistently herpesvirus-infected cells as a second hit might disrupt immune control of ...

No involvement of alveolar macrophages in the initiation of carbon nanoparticle induced acute lung inflammation in mice

Council (CSC). S.C., R.Y. and Y.Y. were the recipients of a fellowship of CSC (2010624122, for Shanze Chen, 2008617097 for Renfu Yin, and 201506240068, for Youjia Yu). Availability of data and materials

Biokinetics of nanoparticles and susceptibility to particulate exposure in a murine model of cystic fibrosis

Chen Manuela Semmler-Behnke Ines Bolle Shinji Takenaka Wolfgang G Kreyling Holger Schulz 0 Institute of Anatomy, Medical Faculty, University of Bern , CH-3012 Bern , Switzerland Background: Persons with