Advanced search    

Search: authors:"Shaohua Wang"

23 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Titanium plate fixation versus conventional approach in the treatment of deep sternal wound infection

Background Deep sternal wound infection (DSWI) is a serious complication post cardiac surgery and associated with increased mortality, morbidity and cost. Sternal titanium plate fixation could be an effective approach to treat DSWI. We sought to compare the effectiveness of titanium plate fixation with conventional approach in the treatment of DSWI. Methods Retrospective data was ...

Lodging Resistance of Japonica Rice (Oryza Sativa L.): Morphological and Anatomical Traits due to top-Dressing Nitrogen Application Rates

Background Lodging in rice production often limits grain yield and quality by breaking or bending stems. Excessive nitrogen (N) fertilizer rates are the cause of poor lodging resistance in rice, but little is known about the effect of top-dressing N application rates on the mechanical strength of japonica rice plants, especially how the anatomical structure in culms is affected by ...

RAGE and AGEs in Mild Cognitive Impairment of Diabetic Patients: A Cross-Sectional Study

Objective Receptor for advanced glycation end products (AGEs; RAGE) binds to both AGEs and amyloid-beta peptides. RAGE is involved in chronic complications of type 2 diabetes and Alzheimer’s disease. We aimed to investigate the roles of RAGE, AGEs and the Gly82Ser polymorphism of RAGE in mild cognitive impairment (MCI) among type 2 diabetes patients. Methods Of the 167 hospitalized ...

Intensified low-density lipoprotein-cholesterol target of statin therapy and cancer risk: a meta-analysis

Wenqing Xia 0 Rong Huang 0 Shaohua Wang 0 0 Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University , No.87 DingJiaQiao Road, Nanjing 210009 , PR China Background: This study

HbA1c below 7 % as the goal of glucose control fails to maximize the cardiovascular benefits: a meta-analysis

Objective Whether lowering glycosylated haemoglobin (HbA1c) level below 7.0 % improves macro-vascular outcomes in diabetes remains unclear. Here, we aimed to assess the effect of relatively tight glucose control resulting in a follow-up HbA1c level of less or more than 7.0 % on cardiovascular outcomes in diabetic patients. Research design and methods We systematically searched ...

Poorly controlled cholesterol is associated with cognitive impairment in T2DM: a resting-state fMRI study

Background Debate remains on whether hypercholesterolemia is associated with cognitive impairment. Hence, we investigated whether poorly controlled cholesterol impairs functional connectivity among patients with type 2 diabetes mellitus (T2DM). Methods Resting-state functional connectivity infers to an interregional cooperation characterized by synchronous and low-frequency (<0.08 ...

Wire `missing�: a rare presentation of preoperative localization wire system dislocation

A full account is presented of a 53-year-old Chinese woman with a small subpleura nodule in the right upper lobe, which was successfully localized by a Dualok-wire system under computed tomography guidance preoperatively. However, during operation, the hook wire was `missing�, neither in the thorax, nor in the lung. With the help of bed-side chest film, the missing wire, which was ...

Does ambroxol confer a protective effect on the lungs in patients undergoing cardiac surgery or having lung resection?

A best evidence topic in perioperative care was written according to a structured protocol. The question addressed was ‘Does ambroxol confer a protective effect on the lung in patients undergoing cardiac surgery or having lung resection?’ A total of 247 papers were found using the reported search, of which 7 represented the best evidence to answer the clinical question. The ...

Proteomic analysis of proteins related to rice grain chalkiness using iTRAQ and a novel comparison system based on a notched-belly mutant with white-belly

Background Grain chalkiness is a complex trait adversely affecting appearance and milling quality, and therefore has been one of principal targets for rice improvement. Eliminating chalkiness from rice has been a daunting task due to the complex interaction between genotype and environment and the lack of molecular markers. In addition, the molecular mechanisms underlying grain ...

MicroRNA expression profiling of the fifth-instar posterior silk gland of Bombyx mori

Background The growth and development of the posterior silk gland and the biosynthesis of the silk core protein at the fifth larval instar stage of Bombyx mori are of paramount importance for silk production. Results Here, aided by next-generation sequencing and microarry assay, we profile 1,229 microRNAs (miRNAs), including 728 novel miRNAs and 110 miRNA/miRNA* duplexes, of the ...

Lower Intensified Target LDL-c Level of Statin Therapy Results in a Higher Risk of Incident Diabetes: A Meta-Analysis

0 Shaohua Wang 0 Michael Lipinski, Washington Hospital Center, United States of America 0 Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University , Nanjing , China

Neuronal Apoptosis and Synaptic Density in the Dentate Gyrus of Ischemic Rats’ Response to Chronic Mild Stress and the Effects of Notch Signaling

Our previous research highlighted an inconsistency with Notch1 signaling-related compensatory neurogenesis after chronic mild stress (CMS) in rodents suffering from cerebral ischemia, which continue to display post-stroke depressive symptoms. Here, we hypothesize that CMS aggrandized ischemia-related apoptosis injury and worsened synaptic integrity via gamma secretase-meditated ...

Arteriovenous fistula after laser-assisted extraction of an implantable defibrillator lead

Laser lead extraction is a relatively new adjunct in managing patients with chronically implanted devices. It carries the potential for a number of procedure-related complications which can present acutely or in a delayed fashion. We present a case of a rather uncommon delayed complication of laser lead extraction and its management with a successful outcome.

The Role of Purinergic Signaling on Deformation Induced Injury and Repair Responses of Alveolar Epithelial Cells

Cell wounding is an important driver of the innate immune response of ventilator-injured lungs. We had previously shown that the majority of wounded alveolus resident cells repair and survive deformation induced insults. This is important insofar as wounded and repaired cells may contribute to injurious deformation responses commonly referred to as biotrauma. The central hypothesis ...

Small Molecules Showing Significant Protection of Mice against Botulinum Neurotoxin Serotype A

Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease known as botulism that could afflict large, unprotected populations if the toxin were employed in an act of bioterrorism. Current post-exposure therapy is limited to symptomatic treatment or passive immunization that is effective for treating infant botulism at a cost of US $45,300 per ...

Small-Molecule Inhibitor Leads of Ribosome-Inactivating Proteins Developed Using the Doorstop Approach

Ribosome-inactivating proteins (RIPs) are toxic because they bind to 28S rRNA and depurinate a specific adenine residue from the α-sarcin/ricin loop (SRL), thereby inhibiting protein synthesis. Shiga-like toxins (Stx1 and Stx2), produced by Escherichia coli, are RIPs that cause outbreaks of foodborne diseases with significant morbidity and mortality. Ricin, produced by the castor ...

Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design

Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease known as botulism. Current treatment for post exposure of BoNTA uses antibodies that are effective in neutralizing the extracellular toxin to prevent further intoxication but generally cannot rescue already intoxicated neurons. Effective small-molecule inhibitors of BoNTA endopeptidase (BoNTAe) ...