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Stable polefinding and rational least-squares fitting via eigenvalues

A common way of finding the poles of a meromorphic function f in a domain, where an explicit expression of f is unknown but f can be evaluated at any given z, is to interpolate f by a rational function \(\frac{p}{q}\) such that \(r(\gamma _i)=f(\gamma _i)\) at prescribed sample points \(\{\gamma _i\}_{i=1}^L\), and then find the roots of q. This is a two-step process and the type...

High Expression of Galectin-3 in Patients with IgG4-Related Disease: A Proteomic Approach

Objectives. Immunoglobulin G4-related disease (IgG4-RD) is a multiorgan condition manifesting itself in different forms. This study aimed to investigate protein expression profiles and to find the possible biomarker for IgG4-RD by liquid chromatography mass spectrometry (LC-MS) using tissue sections in IgG4-RD patients. Methods. Protein expression profiles in five IgG4-related...

Evaluation of 11C-choline PET/CT for primary diagnosis and staging of urothelial carcinoma of the upper urinary tract: a pilot study

Purpose We conducted a pilot study to prospectively evaluate the efficacy of PET/CT with 11C-choline (choline PET/CT) for primary diagnosis and staging of urothelial carcinoma of the upper urinary tract (UUT-UC). Methods Enrolled in this study were 16 patients (9 men, 7 women; age range 51 – 83 years, mean ± SD 69 ± 10.8 years) with suspected UUT-UC. The patients were examined by...

Cholestasis induces reversible accumulation of periplakin in mouse liver

Shinji Ito 0 Junko Satoh 0 Tsutomu Matsubara Yatrik M Shah Sung-hoon Ahn Cherie R Anderson Weiwei Shan Jeffrey M Peters Frank J Gonzalez 0 Biofrontier Platform, Graduate School of Medicine, Kyoto

Hepatocyte-restricted constitutive activation of PPARα induces hepatoproliferation but not hepatocarcinogenesis

Qian Yang 0 Shinji Ito 0 Frank J.Gonzalez 0 0 Laboratory of Metabolism, National Cancer Institute, National Institutes of Health , Bethesda, MD 20892 , USA The Author 2007. Published by Oxford

The PPARα-Humanized Mouse: A Model to Investigate Species Differences in Liver Toxicity Mediated by PPARα

To determine the impact of the species difference between rodents and humans in response to peroxisome proliferators (PPs) mediated by peroxisome proliferator–activated receptor (PPAR)α, PPARα-humanized transgenic mice were generated using a P1 phage artificial chromosome (PAC) genomic clone bred onto a pparα-null mouse background, designated hPPARαPAC. In hPPARαPAC mice, the...