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12 papers found.
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Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity

Nintedanib, a tyrosine kinase inhibitor that is specific for platelet-derived growth factor receptors (PDGFR), fibroblast growth factor receptors (FGFR), and vascular endothelial growth factor receptors (VEGFR), has recently been approved for idiopathic pulmonary fibrosis. Fibrocytes are bone marrow-derived progenitor cells that produce growth factors and contribute to...

Determination of the optimal method for the field-in-field technique in breast tangential radiotherapy

Hidekazu TANAKA Shinya HAYASHI Hiroaki HOSHI Several studies have reported the usefulness of the field-in-field (FIF) technique in breast radiotherapy. However, the methods for the FIF technique

Stereotactic body radiotherapy for very elderly patients (age, greater than or equal to 85 years) with stage I non-small cell lung cancer

Background Stereotactic body radiotherapy (SBRT) for non-small cell lung cancer (NSCLC) is primarily a treatment option for medically inoperable patients, who are often elderly. However, few studies report the effects of SBRT in elderly patients. Thus, we retrospectively analyzed clinical outcomes and feasibility following treatment of very elderly patients (age ≥ 85 years) with...

The contributing factors of tapered wedge stem alignment during mini-invasive total hip arthroplasty

Background Minimally invasive surgical approaches are widely used for total hip arthroplasty (THA). However, potential problems related to a reduced visual field during surgery, such as implant malposition, neurovascular injury, and poor implant fixation, have been reported. In these situations, a shorter stem is easier to insert in the femoral canal. To evaluate the accuracy of...

A phase II study of nab-paclitaxel plus carboplatin in combination with thoracic radiation in patients with locally advanced non–small-cell lung cancer

We investigated the efficacy and safety of albumin-bound paclitaxel (nab-PTX) and carboplatin (CBDCA) with concurrent radiotherapy for unresectable locally advanced non–small-cell lung cancer (NSCLC). Patients with Stage III NSCLC and an Eastern Cooperative Oncology Group performance status of 0 or 1 were eligible. Concurrent chemoradiotherapy consisted of weekly administration...

p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation

Introduction Osteoarthritis (OA) is a multifactorial disease, and recent studies have suggested that cell cycle–related proteins play a role in OA pathology. p21 was initially identified as a potent inhibitor of cell cycle progression. However, it has been proposed that p21 is a regulator of transcription factor activity. In this study, we evaluated the role of p21 in response to...

Hepatic dysfunction after radiotherapy for primary gastric lymphoma

Hidekazu TANAKA Shinya HAYASHI Kazuhiro OHTAKARA Hiroaki HOSHI Patients with primary gastric lymphoma (PGL) are often treated with three-dimensional conformal radiotherapy (3D-CRT) in three to four

P21 Deficiency Delays Regeneration of Skeletal Muscular Tissue

The potential relationship between cell cycle checkpoint control and tissue regeneration has been indicated. Despite considerable research being focused on the relationship between p21 and myogenesis, p21 function in skeletal muscle regeneration remains unclear. To clarify this, muscle injury model was recreated by intramuscular injection of bupivacaine hydrochloride in the...

Dose Gradient Analyses in Linac-based Intracranial Stereotactic Radiosurgery Using Paddick's Gradient Index: Consideration of the Optimal Method for Plan Evaluation

Kazuhiro OHTAKARA Shinya HAYASHI Hiroaki HOSHI Dynamic conformal arc/Gradient index/Linear accelerator/Stereotactic radiosurgery. The objective of our study was to describe the dose gradient

Usefulness of CT-MRI Fusion in Radiotherapy Planning for Localized Prostate Cancer

Hidekazu TANAKA Shinya HAYASHI Kazuhiro OHTAKARA Hiroaki HOSHI Takayoshi IIDA Prostate cancer/Radiotherapy/CT-MRI fusion. We compared the prostate volumes and rectal doses calculated by CT and CT

Osteoarthritis of the talonavicular joint with pseudarthrosis of the navicular bone: a case report

Hayashi 0 Yoshiyuki Takakura Yoshinori Takakura Masahiro Kurosaka 0 0 Department of Orthopedic Surgery, Kobe University Graduate School of Medicine , 7-5-1, Kusunoki-Cho, Tyuo-Ku, Kobe, 650-0017 , Japan