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Chiral dynamics, S-wave contributions and angular analysis in \(D\rightarrow \pi \pi \ell \bar{\nu }\)

We present a theoretical analysis of the \(D^-\rightarrow \pi ^+\pi ^- \ell \bar{\nu }\) and \(\bar{D}^0\rightarrow \pi ^+\pi ^0 \ell \bar{\nu }\) decays. We construct a general angular distribution which can include arbitrary partial waves of \(\pi \pi \). Retaining the S-wave and P-wave contributions we study the branching ratios, forward–backward asymmetries and a few other ...

A fresh look at zebrafish from the perspective of cancer research

Zebrafish represent a vertebrate model organism that has been widely, and increasingly, employed over the last decade in the study of developmental processes, wound healing, microbe-host interactions, and drug screening. With the increase in the laboratory use of zebrafish, several advantages, such as a high genetic homology to humans and transparent embryos, which allow clear ...

Serum IL-10 Predicts Worse Outcome in Cancer Patients: A Meta-Analysis

by two authors (Shuai Zhao and Dang Wu) using standardized data abstraction forms. The following details were collected from individual studies: types of tumor, patient numbers, time of follow up

DNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac

Background Claudin-6 (CLDN6), a member of claudin transmembrane protein family, has recently been reported to be undetectable or at low levels in human breast cancer cell lines and tissues and plays a role in suppression of migration and invasion in breast cancer cells. In addition, it is reported that CLDN6 expression is regulated by DNA methylation in various human cancers and ...

Local application of rapamycin reduces epidural fibrosis after laminectomy via inhibiting fibroblast proliferation and prompting apoptosis

Background Epidural fibrosis is a common complication after laminectomy. It is associated with intractable lower back pain and additional complications. To date, no study has evaluated whether the local application of rapamycin (RAPA) can inhibit fibroblast proliferation and reduce epidural scar adhesion after laminectomy. The results of the present study showed that the local ...

Reduction of intraarticular adhesion of knee by local application of rapamycin in rabbits via inhibition of fibroblast proliferation and collagen synthesis

Background The formation of intraarticular adhesion is a common complication after total knee arthroplasty or anterior cruciate ligament reconstruction. Previously, little research was reported regarding whether the local application of rapamycin (RAPA) could reduce intraarticular adhesion following knee surgery. In our present study, we determined the therapeutic effect of RAPA by ...

Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer

Background Prohibitin (PHB), a pleiotropic protein overexpressed in several tumor types, has been implicated in the regulation of cell proliferation, invasive migration and survival. However, PHB expression and its biological function in gallbladder cancer (GBC) remain largely unknown. Methods PHB and p-ERK protein expressions were determined in human GBC tissues by ...

Comparative genomic, transcriptomic and secretomic profiling of Penicillium oxalicum HP7-1 and its cellulase and xylanase hyper-producing mutant EU2106, and identification of two novel regulatory genes of cellulase and xylanase gene expression

Qing‑Dong Nong Zheng Zhang Lei Jing Ya‑Ru Xiong ChengJ‑ie Duan Jun‑Liang Liu JiaX‑un Feng 0 Shuai Zhao, Yu‐ Si Yan, Qi‐ Peng He, and Lin Yang contributed equally to this work State Key Laboratory for

In situ micro-spectroscopic investigation of lignin in poplar cell walls pretreated by maleic acid

Background In higher plant cells, lignin provides necessary physical support for plant growth and resistance to attack by microorganisms. For the same reason, lignin is considered to be a major impediment to the process of deconstructing biomass to simple sugars by hydrolytic enzymes. The in situ variation of lignin in plant cell walls is important for better understanding of the ...

The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR

Background Gallbladder carcinoma (GBC) is the most common malignancy of the bile duct and patients with GBC have extremely poor prognoses. PIK3CA, which encodes the phosphoinositide 3-kinase (PI3K) subunit p110α, is frequently mutated in many cancers, including GBC. The function of the E545K mutation in GBC is not fully understood. Methods E545K mutation was determined in human GBC ...