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Modulation of Immune Functions by Foods

Central Institute for Microbiological Research, Japan Received 6 May 2004; Accepted 31 August 2004 Copyright © 2004 Shuichi Kaminogawa and Shuichi Kaminogawa. This is an open access article

Post-Transcriptional Regulation of Toll-Interacting Protein in the Intestinal Epithelium

Immune responses against gut microbiota should be minimized to avoid unnecessary inflammation at mucosal surface. In this study, we analyzed the expression patterns of Toll-interacting protein (Tollip), an inhibitor of TLRs and IL-1 family cytokine-related intracellular signaling, in intestinal epithelial cells (IECs). Comparable mRNA expression was observed in murine small and...

Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization, tolerance, and inflammation of food allergy

Background and objective The mechanism inducing either inflammation or tolerance to orally administered food allergens remains unclear. To investigate this we analyzed mouse models of food allergy (OVA23-3) and tolerance (DO11.10 [D10]), both of which express ovalbumin (OVA)-specific T-cell receptors. Methods OVA23-3, recombination activating gene (RAG)-2-deficient OVA23-3 (R23-3...

Peyer’s Patches and Mesenteric Lymph Nodes Cooperatively Promote Enteropathy in a Mouse Model of Food Allergy

Kihara-Fujioka Tomonori Nochi Yosuke Kurashima Osamu Igarashi Masafumi Yamamoto Jun Kunisawa Masako Toda Shuichi Kaminogawa Ryuichiro Sato Hiroshi Kiyono Satoshi Hachimura Sergei Grivennikov, Fox Chase

The active site of carboxypeptidase Taq possesses the active-site motif His–Glu–X–X-His of zinc-dependent endopeptidases and aminopeptidases

Carboxypeptidase (CPase) Taq possesses the His–Glu–X–X–His sequence, which is the consensus sequence in the active site of zinc-dependent endopeptidases and amino-peptidases, at positions 276–280. Amino acid replacement of the conserved His and Glu drastically diminished the activity of CPase Taq, and the zinc content of the enzyme was also greatly reduced when either of the two...

In situ demonstration of intraepithelial lymphocyte adhesion to villus microvessels of the small intestine

The recirculation of lymphocytes through the intestinal mucosa is important for specific immune defense, but the origin and differentiation of intraepithelial lymphocytes (IEL) are not fully understood. The present study therefore used intravital microscopy to investigate the migration of IEL to the villus mucosa and Peyer's patches of the small intestine. IEL were separated from...