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Long noncoding RNA profiling revealed differentially expressed lncRNAs associated with disease activity in PBMCs from patients with rheumatoid arthritis

. Juan Zheng in the key laboratory of ophthalmology, Liaocheng People's Hospital for assistance with the experiments and data analysis. Author Contributions Data curation: Min Yuan, Shujun Wang, Lijie Yu ... , Bo Qu. Formal analysis: Lijie Yu. Funding acquisition: Huaxiang Liu. Investigation: Min Yuan, Lijie Yu, Lining Liu, Yanjun Shi. Methodology: Min Yuan, Shujun Wang, Lijie Yu, Bo Qu, Lining Liu

Preparation, Pharmacokinetic Profile, and Tissue Distribution Studies of a Liposome-Based Formulation of SN-38 Using an UPLC–MS/MS Method

The application of 7-ethyl-10-hydroxycamptothecin (SN-38) in cancer treatment is limited by its low solubility. This study is to develop a liposome-entrapped formulation of SN-38 (LE-SN38) to solve the obstacle and to evaluate its pharmacokinetic profile in dogs and tissue distribution in mice. LE-SN38 which is more likely to be suitable for large-scale production was prepared by ...

Epidemiology of burns in pediatric patients of Beijing City

Background This study aimed to assess the epidemiological characteristics of pediatric burns in Beijing City. Methods This was a retrospective study of pediatric patients (n = 400) admitted to four burn centers in Beijing City between June 2010 and May 2011. Burn severity was determined according to total body surface area (TBSA) percentage and degree. Patients were followed up for ...

Microsatellite Variations of Elite Setaria Varieties Released during Last Six Decades in China

, for discussion and modification of the manuscript. Conceived and designed the experiments: XD. Performed the experiments: GJ XL YL Shujun Wang Suying Wang. Analyzed the data: GJ XD. Contributed reagents

Cardioprotective Effects of a Novel Hydrogen Sulfide Agent–Controlled Release Formulation of S-Propargyl-Cysteine on Heart Failure Rats and Molecular Mechanisms

Objective Heart failure (HF) is one of the most serious diseases worldwide. S-propargyl-cysteine (SPRC), a novel modulator of endogenous hydrogen sulfide, is proved to be able to protect against acute myocardial ischemia. In order to produce more stable and sustainable hydrogen sulfide, we used controlled release formulation of SPRC (CR-SPRC) to elucidate possible cardioprotective ...

OVA66, a Tumor Associated Protein, Induces Oncogenic Transformation of NIH3T3 Cells

The tumor associated antigen OVA66 has been demonstrated to be highly expressed in malignant tumors and implicated in various cellular processes. To further elucidate its oncogenic character, we established an OVA66 stably overexpressed NIH3T3 cell line and a vector transfected control, named NIH3T3-flagOVA66 and NIH3T3-mock, respectively. NIH3T3-flagOVA66 cells showed faster cell ...

A new alternating copolymerized derivative as a cold flow improver for diesel fuel

Synthesis of a cold flow improver (MAVA-a) for diesel fuel and its effect on solidifying point (SP) and cold filter plugging point (CFPP) of diesel fuels were investigated. The cold flow improver was prepared by using maleic anhydride (MA) and vinyl acetate (VA) as raw materials, toluene as solvent, dibenzoyl peroxide (BPO) as initiator, through alternating polymerization under ...

A review of recent progress in preparation of hollow polymer microspheres

The preparation methods of hollow polymer microspheres both at home and abroad are summarized, and their preparation mechanisms and developmental states are presented. These methods include the liquid droplet method, dried-gel droplet method, self-assembly method, microencapsulation method, emulsion polymerization method and the template method. Hollow polystyrene microspheres are ...