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Downregulated GTCPH I/BH4 Pathway and Decreased Function of Circulating Endothelial Progenitor Cells and Their Relationship with Endothelial Dysfunction in Overweight Postmenopausal Women

Zhenhua Huang,2 Jinli Liao,2 Zhihao Liu,2 Xiaopeng Li,3 Shun Yao,4 Hao He,5 Dajun Hu,1 Zi Ren,6 Haitao Zeng,6 Quanneng Yan,7 and Hong Zhan2 1Department of Geriatric Medicine, Xiangya Hospital, Central ... , Zhihao Liu, Xiaopeng Li, Shun Yao, Hao He, Dajun Hu, Zi Ren, Haitao Zeng, Quanneng Yan, and Hong Zhan together designed the project, performed the experiments, collected the data, analyzed the data and

Application value of selected serum indicators in the differential diagnosis of geriatric depression and transient depressive state

Application value of selected serum indicators in the differential diagnosis of geriatric depression and transient depressive state Yuhao Xu,1,* Shun Yao,2,* Hong Wei,1 Xiaolan Zhu,3 Ming Yu,1

Association between a frailty index based on common laboratory tests and QTc prolongation in older adults: the Rugao Longevity and Ageing Study

,5 Yong Wang,5 Guo-Ping Shi,5 Zheng-Dong Wang,5 Shun Yao,1–3 Xiao-Feng Wang,1–3 Xiao-Yan Jiang6–8 1Unit of Epidemiology, Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan

Prior knowledge driven Granger causality analysis on gene regulatory network discovery

Background Our study focuses on discovering gene regulatory networks from time series gene expression data using the Granger causality (GC) model. However, the number of available time points (T) usually is much smaller than the number of target genes (n) in biological datasets. The widely applied pairwise GC model (PGC) and other regularization strategies can lead to a...

Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia

for Ira Pastan in:Nature Research journals • PubMed • Google Scholar Search for Nai-Shun Yao in:Nature Research journals • PubMed • Google Scholar Search for Francis Giles in:Nature Research journals

Risk of serous retinal detachment in patients with end-stage renal disease on dialysis

The aim of this retrospective, nationwide, matched cohort study was to investigate the association of serous retinal detachment with having end-stage renal disease (ESRD) while on dialysis. The cohort study included 94,024 patients with ESRD on dialysis registered between January 2000 to December 2009 in the Taiwan National Health Insurance Research Database. An age- and sex...

Growth of AlGaN Film on Si (111) Substrate

At present, the applications of AlxGa1−xN are extensive, such as for visible-blind ultraviolet detectors, laser diodes, light emitting diodes (LEDs) and HEMTs. In this paper, Al0.25Ga0.75N and Al0.32Ga0.68N films have been grown on 2 in Si (iii) substrates by MOCVD. The low-temperature (6 K) photoluminescence (PL) spectrum and XRD rocking curve measurements have been employed to...

Evaluation of the Antibacterial Potential of Liquid and Vapor Phase Phenolic Essential Oil Compounds against Oral Microorganisms

The aim of the present study was to determine the antibacterial activities of the phenolic essential oil (EO) compounds hinokitiol, carvacrol, thymol, and menthol against oral pathogens. Aggregatibacter actinomycetemcomitans, Streptococcus mutans, Methicillin-resistant Staphylococcus aureus (MRSA), and Escherichia. coli were used in this study. The minimum inhibitory...

The Possible Mechanism of Advanced Glycation End Products (AGEs) for Alzheimer’s Disease

Amyloid precursor protein (APP) has been modified by β and γ-secretase that cause amyloid deposits (plaques) in neuronal cells. Glyceraldhyde-derived AGEs has been identified as a major source of neurotoxicity in Alzheimer’s disease (AD). In a previous study, we demonstrated that glyceraldehyde-derived AGEs increase APP and Aβ via ROS. Furthermore, the combination of AGEs and A...

Fabrication and characterization of novel tentacle-type adsorbent for resolution of chiral drugs

Novel tentacle-type chiral adsorbent based on silica gels modified with β-cyclodextrin (β-CD) and polyvinyl alcohol(PVA) is synthesized by surface grafting technique. The adsorption behavior of chiral pharmaceuticals using the resulting adsorbents is investigated. In the study, FT-IR and thermogravimetric analysis (TGA) are employed to characterize the chemical and physical...

Cell Migration Is Regulated by AGE-RAGE Interaction in Human Oral Cancer Cells In Vitro

Advanced glycation end products (AGEs) are produced in an irreversible non-enzymatic reaction of carbohydrates and proteins. Patients with diabetes mellitus (DM) are known to have elevated AGE levels, which is viewed as a risk factor of diabetes-related complications. In a clinical setting, it has been shown that patients with oral cancer in conjunction with DM have a higher...

Evaluation Physical Characteristics and Comparison Antimicrobial and Anti-Inflammation Potentials of Dental Root Canal Sealers Containing Hinokitiol In Vitro

Hinokitiol displays potent antimicrobial activity. It has been used in toothpaste and oral-care gel to improve the oral lichen planus and reduce halitosis. The aim of this study was to evaluate the antimicrobial activity of 3 different dental root canal sealers with hinokitiol (sealers+H) and their physical and biological effects. AH Plus (epoxy amine resin-based, AH), Apexit...

Hematuria after Orthopedic Tuina: A Case Report and Brief Review of Literature

We present a case of a 24-year-old man who presented hematuria after the orthopedic tuina, which has not been recorded previously in the literature. We review complications of tuina in the literature too.

YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression

, Fuming Li, Zhaoyuan Fang, Xinyuan Tong, Shun Yao, Fei Li, Yan Feng, Lei Zhang & Hongbin JiDepartment of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai 200092, ChinaXujun ... ScholarSearch for Xinyuan Tong in:Nature Research journals • PubMed • Google ScholarSearch for Shun Yao in:Nature Research journals • PubMed • Google ScholarSearch for Fei Li in:Nature Research journals • PubMed

Effect of Jiaji electroacupuncture in transected rat spinal cord

We evaluated the effect of Jiaji electroacupuncture on cell proliferation and the expression of markers of endogenous neural stem cell activation after complete spinal cord transection. Female Wistar rats were assigned to 4 groups (n = 24 each): a sham-operated group, a control group, a Jiaji electroacupuncture group, and a Jiaji electroacupuncture preconditioning group. Motor...