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The value of knowledge accumulation on climate sensitivity uncertainty: comparison between perfect information, single stage and act then learn decisions

, Japan 1 Tokyo University of Science , Yamasaki 2641, Noda-shi, Chiba 278-8510 , Japan 2 Handled by Dr. Kiyoshi Takahashi, National Institute for Environmental Studies , Japan 3 Shunsuke Mori In COP21

Assessment of mitigation strategies as tools for risk management under future uncertainties: a multi-model approach

Although the world understands the possible threat of the future of climate changes, there remain serious barriers to be resolved in terms of policy decisions. The scientific and the societal uncertainties in the climate change policies must be the large part of this barrier. Following the Paris Agreement, the world comes to the next stage to decide the next actions. Without a...

Risk implications of long-term global climate goals: overall conclusions of the ICA-RUS project

We have assessed the risks associated with setting 1.5, 2.0, or 2.5 °C temperature goals and ways to manage them in a systematic manner and discussed their implications. The results suggest that, given the uncertainties in climate sensitivity, “net zero emissions of anthropogenic greenhouse gases in the second half of this century” is a more actionable goal for society than the 2...

Prevalence of and factors associated with renal dysfunction in rheumatoid arthritis patients: a cross-sectional study in community hospitals

-5117 , Japan 2 Shunsuke Mori This study was designed to determine the prevalence of renal dysfunction in rheumatoid arthritis (RA) patients and to identify factors associated with this complication

A new approach of carbon emission allocation among stakeholders: an expansion of Multiregional and Multisectoral Dynamic Energy-Economic Model THERESIA

This paper aims at the assessment of the sectoral/regional partial participation in the global warming coalition applying the Multiregional and Multisectoral Dynamic Energy-Economic Model THERESIA based on GTAP database, dealing with 15 world regions and 12 non-energy industry sectors and 7 energy sectors to assess the middle- to long-term global warming policies. This study...

Comparative risk of hospitalized infection between biological agents in rheumatoid arthritis patients: A multicenter retrospective cohort study in Japan

Objective Knowing the risk of hospitalized infection associated with individual biological agents is an important factor in selecting the best treatment option for patients with rheumatoid arthritis (RA). This study examined the comparative risk of hospitalized infection between biological agents in a routine care setting. Methods We used data for all RA patients who had first...

Glucocorticoid-resistant polymyalgia rheumatica: pretreatment characteristics and tocilizumab therapy

Shunsuke Mori 0 Yukinori Koga 0 0 Y. Koga Department of Radiology, Clinical Research Center for Rheumatic Disease, NHO Kumamoto Saishunsou National Hospital , Kumamoto, Japan 1 ) Department of

Factors Associated with Myelosuppression Related to Low-Dose Methotrexate Therapy for Inflammatory Rheumatic Diseases

Objective Severe myelosuppression is a serious concern in the management of rheumatic disease patients receiving methotrexate (MTX) therapy. This study was intended to explore factors associated with the development of MTX-related myelosuppression and its disease severity. Methods We retrospectively examined a total of 40 cases of MTX-related myelosuppression that had been filed...

Past hepatitis B virus infection in rheumatoid arthritis patients receiving biological and/or nonbiological disease-modifying antirheumatic drugs

Shunsuke Mori 0 0 S. Mori (&) Clinical Research Center for Rheumatic Disease, Department of Rheumatology, NHO Kumamoto Saishunsou National Hospital , 2659 Suya, Kohshi, Kumamoto 861-1196, Japan To

The Significance of the Prognostic Nutritional Index in Patients with Completely Resected Non-Small Cell Lung Cancer

Objectives Immunological parameters and nutritional status influence the outcome of patients with malignant tumors. A prognostic nutritional index, calculated using serum albumin levels and peripheral lymphocyte count, has been used to assess prognosis for various cancers. This study aimed to investigate whether this prognostic nutritional index affects overall survival and the...

Primary lack of efficacy of infliximab therapy for rheumatoid arthritis: pharmacokinetic characterization and assessment of switching to tocilizumab

To characterize primary failure to infliximab and determine the efficacy of switching to tocilizumab in patients with rheumatoid arthritis (RA), we examined 24 RA patients who had started on infliximab therapy (3 mg/kg) as their first biological agent. Nine of the 24 patients were found to be primary nonresponders, defined as patients who had never achieved a 20% clinical...

The 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: a double-blinded, randomized, placebo-controlled trial

Background Pneumococcal pneumonia is the most frequent form of pneumonia. We herein assessed the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in the prevention of pneumonia overall in rheumatoid arthritis (RA) patients at risk for infections. We hypothesized that PPSV23 vaccination is superior in preventing pneumococcal pneumonia compared with...

The mTOR Pathway Controls Cell Proliferation by Regulating the FoxO3a Transcription Factor via SGK1 Kinase

The mechanistic target of rapamycin (mTOR) functions as a component of two large complexes, mTORC1 and mTORC2, which play crucial roles in regulating cell growth and homeostasis. However, the molecular mechanisms by which mTOR controls cell proliferation remain elusive. Here we show that the FoxO3a transcription factor is coordinately regulated by mTORC1 and mTORC2, and plays a...

Small airway obstruction in patients with rheumatoid arthritis

This work was intended to evaluate the prevalence of obstructive small-airway disease in patients with rheumatoid arthritis (RA) and its association with clinical characteristics. Pulmonary function testing (PFT) and high-resolution computed tomography (HRCT) were performed on 189 consecutive RA patients. Each case was diagnosed based on abnormal HRCT findings. We defined...

Effect of abatacept on the immunogenicity of 23-valent pneumococcal polysaccharide vaccination (PPSV23) in rheumatoid arthritis patients

Introduction Patients with rheumatoid arthritis (RA) treated with abatacept (ABT) are at increased risk for vaccine-preventable infections. The aim of the present study is to evaluate the humoral response to 23-valent pneumococcal polysaccharide (PPSV23) vaccination in RA patients receiving ABT. Methods The immunogenicity study was nested within a randomized, double-blind placebo...

Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tacrolimus

Fuminori Hirano Haruko Ideguchi Ryutaro Matsumura Eiichi Suematsu Tomoya Miyamura Shunsuke Mori Takahiro Fukui Yasumori Izumi Nozomi Iwanaga Hiroshi Tsutani Kouichirou Saisyo Takao Yamanaka Shiro Ohshima

Rates of Serious Intracellular Infections in Autoimmune Disease Patients Receiving Initial Glucocorticoid Therapy

Background/Aims The Japanese National Hospital Organization evidence-based medicine (EBM) Study group for Adverse effects of Corticosteroid therapy (J-NHOSAC) is a Japanese hospital-based cohort study investigating the safety of the initial use of glucocorticoids (GCs) in patients with newly diagnosed autoimmune diseases. Using the J-NHOSAC registry, the purpose of this...

Radiological features and therapeutic responses of pulmonary nontuberculous mycobacterial disease in rheumatoid arthritis patients receiving biological agents: a retrospective multicenter study in Japan

Objective This study was performed to evaluate the radiological features of and therapeutic responses to pulmonary disease caused by nontuberculous mycobacteria (NTM) in the setting of biological therapy for rheumatoid arthritis (RA). Methods We conducted a retrospective chart review of 13 patients from multiple centers who had developed pulmonary NTM disease during biological...