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International tuberculosis research collaborations within Asia

Background Asia bears more than half the global tuberculosis (TB) burden. Economic development in the region has increased available funding for biomedical research and opportunity for collaboration. We explored the extent of international tuberculosis research collaborations between institutions within Asia. Methods We conducted a Pubmed search for all articles with tuberculosis...

Nitric oxide has contrasting age-dependent effects on the functionality of murine hematopoietic stem cells

Background The success of hematopoietic stem cell (HSC) transplantation is dependent on the quality of the donor HSCs. Some sources of HSCs display reduced engraftment efficiency either because of inadequate number (e.g., fetal liver and cord blood), or age-related dysfunction (e.g. in older individuals). Therefore, use of pharmacological compounds to improve functionality of...

Schrodinger’s scat: a critical review of the currently available tiger (Panthera Tigris) and leopard (Panthera pardus) specific primers in India, and a novel leopard specific primer

specific primer Pranay Amruth Maroju 0 Sonu Yadav 0 Vishnupriya Kolipakam Shweta Singh Qamar Qureshi Yadvendradev Jhala 0 Equal contributors Wildlife Institute of India , Chandrabani, Dehradun 248001

Attachment Site Selection and Identity in Bxb1 Serine Integrase-Mediated Site-Specific Recombination

Phage-encoded serine integrases mediate directionally regulated site-specific recombination between short attP and attB DNA sites without host factor requirements. These features make them attractive for genome engineering and synthetic genetics, although the basis for DNA site selection is poorly understood. Here we show that attP selection is determined through multiple...

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

V. Gurevich, Daniel Fourmy, Vadim Cherezov, Fiona H. Marshall, R. Ian Storer, Isabel Moraes, Irina G. Tikhonova, Christofer S. Tautermann, Peter Hunt, Tom Ceska, Simon Hodgson, Mike J. Bodkin, Shweta ... Singh, Richard J. Law and Philip C 5 I. G. Tikhonova Molecular Therapeutics, School of Pharmacy, Medical Biology Centre, Queen's University Belfast , 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland

Large-scale functional expression of WT and truncated human adenosine A2A receptor in Pichia pastoris bioreactor cultures

Background The large-scale production of G-protein coupled receptors (GPCRs) for functional and structural studies remains a challenge. Recent successes have been made in the expression of a range of GPCRs using Pichia pastoris as an expression host. P. pastoris has a number of advantages over other expression systems including ability to post-translationally modify expressed...