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AR negative triple negative or “quadruple negative” breast cancers in African American women have an enriched basal and immune signature

acquisition: Clayton Yates. Investigation: Melissa Davis, Shweta Tripathi, Raymond Hughley, Balasubramanyam Karanam, Windy Colomb, William Grizzle, Clayton Yates. tini, Windy Colomb, William Grizzle, Clayton

Influence of water soluble carbon dots on the growth of wheat plant

The effect of water soluble carbon nano-dots (wsCND) on the growth of root and shoot of wheat plants under light and dark conditions has been studied. The wsCND enhances the growth of root and shoot both in light and dark conditions. The effect of wsCND on the growth of root was relatively more compared to that of shoot. Scanning electron and Fluorescence microscopic analysis...

Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis

The human cathelicidin LL-37 has been shown to play a role in host defense against influenza A viruses (IAV) through direct antiviral effects and through modulating inflammatory responses to infection. We recently showed that LL-37 increases neutrophil respiratory burst and neutrophil extracellular trap (NET) responses to IAV through engaging formyl peptide receptor 2 (FPR-2). In...

Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses

Human LL-37, a cationic antimicrobial peptide, was recently shown to have antiviral activity against influenza A virus (IAV) strains in vitro and in vivo. In this study we compared the anti-influenza activity of LL-37 with that of several fragments derived from LL-37. We first tested the peptides against a seasonal H3N2 strain and the mouse adapted H1N1 strain, PR-8. The N...

Alzheimer's Associated β-Amyloid Protein Inhibits Influenza A Virus and Modulates Viral Interactions with Phagocytes

Accumulation of β-Amyloid (βA) is a key pathogenetic factor in Alzheimer's disease; however, the normal function of βA is unknown. Recent studies have shown that βA can inhibit growth of bacteria and fungi. In this paper we show that βA also inhibits replication of seasonal and pandemic strains of H3N2 and H1N1 influenza A virus (IAV) in vitro. The 42 amino acid fragment of βA...

Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection

Background Activity of cytochrome P450 (CYP), a polymorphic carcinogen-activating enzyme, is exaggerated following Helicobacter pylori infection. We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis. Methods Genotyping of CYP2E1 (96-bp insertion), CYP1A2 (164A to C), and CYP1A1...