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52 papers found.
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Rational therapeutic targets with biomolecular liquid-liquid phase separation regulating synergy: A pan-cancer analysis

needed. We thanked Dr. Miao Wang (Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) for his kind advices. Funding acquisition: Si Sun, Man Xiao ... , Minggang Peng, Qiang Yang. Conceptualization: Qiang Yang, Xiaoqi He. Data curation: Wenwen Wang, Guoqing Li. Formal analysis: Si Sun. Investigation: Jing Cai. Methodology: Wenwen Wang. Project

New logarithm-based discrimination formula for differentiating thalassemia trait from iron deficiency anemia in pregnancy

Thalassemia trait (TT) and iron deficiency anemia (IDA) are the most common conditions of microcytic hypochromic anemia (MHA) in pregnant women. Accurate discrimination between TT and IDA is an important issue, and better methods are urgently needed. Although considerable RBC formulas and indices have been developed since 1973, distinguishing between IDA and TT is still a...

Centrosome-phagy: implications for human diseases

), Health commission of Hubei Province scientific research project (Grant No. WJ2019Q053) and a Natural Science Foundation of Hubei (Grant No. 2018CKB916) to Dr. Si Sun. Availability of data and materials Not

Size measurements of hepatocellular carcinoma: comparisons between contrast and two-dimensional ultrasound

Technology. Author information Author notes Fei Chen and Fei Wang: First authors Affiliations Department of Ultrasound, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China Fei Chen, Si Sun ... this author in PubMed Google Scholar Fei Wang View author publications You can also search for this author in PubMed Google Scholar Si Sun View author publications You can also search for this

Cancer-associated adipocytes as immunomodulators in cancer

the final manuscript. Funding This work was supported by a National Natural Science Foundation of China (NSFC) grant (Grant NO: 81471781) to Prof. Shengrong Sun and (Grant NO: 81903166) to Dr. Si Sun ... . This work was also supported by a Natural Science Foundation of Hubei (Grant No. 2018CKB916) to Dr. Si Sun. Availability of data and materials Not applicable. Ethics approval and consent to participate

Centrosome dysfunction: a link between senescence and tumor immunity

also supported by National NSFC Grant No. 81903166 and Hubei Province health and family planning scientific research project Grant No. WJ2019Q044 to Dr. Si Sun. AUTHOR CONTRIBUTIONS Q.W. and Sh.S

DNER promotes epithelial–mesenchymal transition and prevents chemosensitivity through the Wnt/β-catenin pathway in breast cancer

Breast cancer (BC) is the most common malignant tumour in women worldwide, and one of the most common fatal tumours in women. Delta/Notch-like epidermal growth factor (EGF)-related receptor (DNER) is a transmembrane protein involved in the development of tumours. The role and potential mechanism of DNER in epithelial–mesenchymal transition (EMT) and apoptosis in BC are not fully...

Cancer-associated adipocytes: key players in breast cancer progression

• Google Scholar Search for Juanjuan Li in:PubMed • Google Scholar Search for Si Sun in:PubMed • Google Scholar Search for Shengrong Sun in:PubMed • Google Scholar Contributions ZL and JL are responsible ... approved the final manuscript. Corresponding authors Correspondence to Si Sun or Shengrong Sun. Ethics declarations Ethics approval and consent to participate Does not apply as it is a review article

Chinese perspectives on clinical efficacy and safety of alectinib in patients with ALK-positive advanced non-small cell lung cancer

Chinese perspectives on clinical efficacy and safety of alectinib in patients with ALK-positive advanced non-small cell lung cancer Hui Yu,1 Si Sun,1 Xingjiang Hu,2 Jinjing Xia,3 Jialei Wang,1 ... Edanz Medical Writing, for providing medical writing assistance, which was funded by Shanghai Roche Pharmaceuticals Ltd. This work was funded by Shanghai Roche Pharmaceuticals Ltd. Hui Yu and Si Sun

Influence of the Hydraulic Boundary Condition between the Embankment and Saturated Half-Space on the Train-Induced Ground Vibration

A three-dimensional analytical model was proposed to investigate the influence of the hydraulic boundary of the ground surface on the train-induced ground vibrations. The ground was simulated as a fully saturated poroelastic half-space and the embankment as a rectangular elastic soil layer with finite width. The rails and the sleepers were modeled as Euler beams and a Kirchhoff...

Influence of the Hydraulic Boundary Condition between the Embankment and Saturated Half-Space on the Train-Induced Ground Vibration

A three-dimensional analytical model was proposed to investigate the influence of the hydraulic boundary of the ground surface on the train-induced ground vibrations. The ground was simulated as a fully saturated poroelastic half-space and the embankment as a rectangular elastic soil layer with finite width. The rails and the sleepers were modeled as Euler beams and a Kirchhoff...

Alterations in Immune-Related Genes as Potential Marker of Prognosis in Breast Cancer

The tumor microenvironment (TME) is a heterogeneous system that contributes to breast cancer progression. The Cancer Genome Atlas (TCGA) database provides global gene expression profiling data for further analysis of various malignancies, including breast cancer. Based on the ESTIMATE algorithm, immune and stromal scores were calculated according to immune or stromal components...

ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2 Q607R

RNA editing by adenosine deaminases acting on RNA (ADARs) converts adenosines to inosines (A-to-I) in RNA, that alters gene expression and generates protein diversity. Dysregulation of A-to-I editing has been found associated with a number of nervous system diseases. However, the role of ADAR3, a brain specific high expression adenosine deaminase, in gliomas has rarely been...

The role of phosphate-containing medications and low dietary phosphorus-protein ratio in reducing intestinal phosphorus load in patients with chronic kidney disease

Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in patients experiencing end-stage renal disease (ESRD). It includes abnormalities in bone and mineral metabolism and vascular calcification. Hyperphosphatemia is a major risk factor leading to morbidity and mortality in patients with chronic kidney disease. Increased mortality has been observed...

Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression

Emerging evidence supports the pivotal roles of adipocytes in breast cancer progression. Tumour induced beige/brown adipose tissue differentiation contributes to the hypermetabolic state of the breast cancer. However, the mediators and mechanisms remain unclear. Survival probabilities were estimated using the Kaplan–Meier method based on immunohistochemistry results. Biochemical...

Crizotinib in Chinese Patients with ROS1-Rearranged Advanced Non‒Small-Cell Lung Cancer in Routine Clinical Practice

, Yuan Li, Weixin Zhao, Kuaile Zhao, Zhengfei Zhu, Si Sun, Min Fan, Jialei Wang have no conflicts of interest that are directly relevant to the content of this article. References 1. Sateia HF, Choi Y

miR-27a inhibits cervical adenocarcinoma progression by downregulating the TGF-βRI signaling pathway

High-risk human papillomavirus infection is essential for the malignant transformation of cervical cancer and can inhibit host miR-27a expression. We investigated the role and mechanism of miR-27a in cervical cancer progression. miR-27a is decreased in cervical cancer cell lines and miR-27a-agomir inhibited the cell proliferation, migration, and invasion properties of HeLa...

Prognostic Value and Implication for Chemotherapy Treatment of ABCB1 in Epithelial Ovarian Cancer: A Meta-Analysis

Background Chemotherapy resistance is reported to correlate with up-regulation of anti-tumor agent transporter ABCB1 (p-gp) in epithelial ovarian cancer (EOC), but the results remain controversial. To reconcile the results, a systematic review followed by meta-analysis was performed to assess the association between high ABCB1 status or ABCB1 gene variants and overall survival...

Tumour-originated exosomal miR-155 triggers cancer-associated cachexia to promote tumour progression

for the diverse pathologic effects of tumour on various organs either through activating their targets. Notes Qi Wu and Si Sun contributed equally to this work. Abbreviations AMPK:  AMP-activated