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18 papers found.
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Minor defects of the luminal integrity in arterial introducer eSheaths after transcatheter aortic valve implantation

Background Medical devices such as implant delivery systems are commonly used during minimally invasive procedures in the cardiovascular system. These devices often have lubricious polymer coatings to reduce friction between the device and blood vessels but coatings may separate and potentially cause serious injuries to patients. Methods Lubricious coated eSheaths for...

Prognostic Value of Overexpressed p16INK4a in Vulvar Cancer: A Meta-Analysis

specimens. Data extraction Three investigators (Hanyu Cao, Si Wang, and Zhenyu Zhang) extracted independently all articles complying with the aforementioned inclusion criteria. Any discrepancy was resolved

CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

WITH ETHICS GUIDELINES Lixia Wang, Fei Yi, Lina Fu, Jiping Yang, Si Wang, Zhaoxia Wang, Keiichiro Suzuki, Liang Sun, Xiuling Xu, Yang Yu, Jie Qiao, Juan Carlos Izpisua Belmonte, Ze Yang, Yun Yuan, Jing

Analysis of Pvama1 genes from China-Myanmar border reveals little regional genetic differentiation of Plasmodium vivax populations

Background With the premise of diminishing parasite genetic diversity following the reduction of malaria incidence, the analysis of polymorphic antigenic markers may provide important information about the impact of malaria control on local parasite populations. Here we evaluated the genetic diversity of Plasmodium vivax apical membrane antigen 1 (Pvama1) gene in a parasite...

Night Shift Work and Breast Cancer Incidence: Three Prospective Studies and Meta-analysis of Published Studies

Background: It has been proposed that night shift work could increase breast cancer incidence. A 2007 World Health Organization review concluded, mainly from animal evidence, that shift work involving circadian disruption is probably carcinogenic to humans. We therefore aimed to generate prospective epidemiological evidence on night shift work and breast cancer incidence. Methods...

Elevated resting heart rate predisposes metabolic syndrome in women rather than in men: a 15-year prospective study

Background Increasing evidences have indicated that there are gender differences in the prevalence of metabolic syndrome(MS), but the mechanism is uncertain. Methods A total of 711 subjects aged 35–65 years accepted health examinations both in 1992 and 2007. Since 114 subjects had MS and 7 had heart disease at baseline, they were excluded from the analysis. Therefore, 590...

Mesenchymal Stem Cells Stabilize Atherosclerotic Vulnerable Plaque by Anti-Inflammatory Properties

Background and objectives Formation and progression of atherosclerotic vulnerable plaque (VP) is the primary cause of many cardio-cerebrovascular diseases such as acute coronary syndrome and stroke. It has been reported that bone marrow mesenchymal stem cells (MSC) exhibit protective effects against many kinds of diseases including myocardial infarction. Here, we examined the...

Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

pigmentosum. COMPLIANCE WITH ETHICS GUIDELINES Lina Fu, Xiuling Xu, Ruotong Ren, Jun Wu, Weiqi Zhang, Jiping Yang, Xiaoqing Ren, Si Wang, Yang Zhao, Liang Sun, Yang Yu, Zhaoxia Wang, Ze Yang, Yun Yuan, Jie

Dihydrochalcone glycosides from Oxytropis myriophylla

Gaimei She 0 Si Wang 0 Bin Liu 0 0 School of Chinese Pharmacy, Beijing University of Chinese Medicine , Beijing, People's Republic of China Chemical investigations of the 70% alcohol extract of

First-Morning Urinary Melatonin and Breast Cancer Risk in the Guernsey Study

Xiao-Si Wang Sarah Tipper Paul N. Appleby Naomi E. Allen Timothy J. Key Ruth C. Travis ) It has been hypothesized that suppressed nocturnal melatonin production is associated with an increased risk ... ). ACKNOWLEDGMENTS Author affiliations: Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom (Naomi E. Allen, Paul N. Appleby, Timothy J. Key, Sarah Tipper, Ruth C. Travis, Xiao-Si Wang); and

Kaiso Interacts with p120-Catenin to Regulate β-Catenin Expression at the Transcriptional Level

Background We have reported that p120-catenin could regulate β-catenin transcription in lung cancer cells, but the specific mechanism is unclear. Methods and Results In this study, bisulfite sequencing PCR showed that the β-catenin promoter region in SPC-A-1 and LTEP-a-2 lung cancer cell lines has Kaiso binding sites sequences and CpG islands which may combine with Kaiso. The...

Extending an In Vitro Panel for Estrogenicity Testing: The Added Value of Bioassays for Measuring Antiandrogenic Activities and Effects on Steroidogenesis

In the present study, a previously established integrated testing strategy (ITS) for in vitro estrogenicity testing was extended with additional in vitro assays in order to broaden its sensitivity to different modes of action resulting in apparent estrogenicity, i.e., other than estrogen receptor (ER) binding. To this end, an extra set of 10 estrogenic compounds with modes of...

Abnormal expression of Pygopus 2 correlates with a malignant phenotype in human lung cancer

Background Pygopus 2 (Pygo2) is a Pygo family member and an important component of the Wnt signaling transcriptional complex. Despite this data, no clinical studies investigating Pygo2 expression in lung cancer have yet been reported. Methods In the present study, the expression patterns of Pygo2 were evaluated by immunochemistry in 168 patients with non-small cell lung cancer...

Cardioprotective Effect of Paeonol and Danshensu Combination on Isoproterenol-Induced Myocardial Injury in Rats

Background Traditional Chinese medicinal herbs Cortex Moutan and Radix Salviae Milthiorrhizaeare are prescribed together for their putative cardioprotective effects in clinical practice. However, the rationale of the combined use remains unclear. The present study was designed to investigate the cardioprotective effects of paeonol and danshensu (representative active ingredient...