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10 papers found.
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Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?

Recent studies have demonstrated that the bacterial chaperone and serine protease high temperature requirement A (HtrA) is closely associated with the establishment and progression of several infectious diseases. HtrA activity enhances bacterial survival under stress conditions, but also has direct effects on functions of the cell adhesion protein E-cadherin and extracellular ...

HtrA-mediated E-cadherin cleavage is limited to DegP and DegQ homologs expressed by gram-negative pathogens

Camilla Götz Thomas P. Schmidt Gernot Posselt Silja Wessler 0 Equal contributors Division of Microbiology, Department of Molecular Biology, Paris-Lodron University of Salzburg , Billroth Str. 11, A-5020

The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis

Silja Wessler 0 0 Division of Molecular Biology, Department of Microbiology, Paris-Lodron University , Salzburg , Austria 1 Department of Biology, Institute for Microbiology, Friedrich Alexander

Transmigration route of Campylobacter jejuni across polarized intestinal epithelial cells: paracellular, transcellular or both?

Silja Wessler Nicole Tegtmeyer 0 0 Department of Biology, Institute for Microbiology, Friedrich Alexander University Erlangen/Nuremberg , Staudtstr. 5, D-91058, Erlangen , Germany Intact intercellular

Peroxiredoxin 6 promotes upregulation of the prion protein (PrP) in neuronal cells of prion-infected mice

Wessler 0 0 Division of Microbiology, University of Salzburg , Billrothstrasse 11, Salzburg A-5020 , Austria Background: It has been widely established that the conversion of the cellular prion protein

Regulation of the actin cytoskeleton in Helicobacter pylori-induced migration and invasive growth of gastric epithelial cells

Dynamic rearrangement of the actin cytoskeleton is a significant hallmark of Helicobacter pylori (H. pylori) infected gastric epithelial cells leading to cell migration and invasive growth. Considering the cellular mechanisms, the type IV secretion system (T4SS) and the effector protein cytotoxin-associated gene A (CagA) of H. pylori are well-studied initiators of distinct signal ...

Quantitative phosphoproteomic analysis of prion-infected neuronal cells

Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal diseases associated with the conversion of the cellular prion protein (PrPC) to the abnormal prion protein (PrPSc). Since the molecular mechanisms in pathogenesis are widely unclear, we analyzed the global phospho-proteome and detected a differential pattern of tyrosine- and threonine phosphorylated ...

Inhibitors of Helicobacter pylori Protease HtrA Found by ‘Virtual Ligand’ Screening Combat Bacterial Invasion of Epithelia

Background The human pathogen Helicobacter pylori (H. pylori) is a main cause for gastric inflammation and cancer. Increasing bacterial resistance against antibiotics demands for innovative strategies for therapeutic intervention. Methodology/Principal Findings We present a method for structure-based virtual screening that is based on the comprehensive prediction of ligand binding ...