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Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort

) cohort Francesca Cordero Giulio Ferrero 1 Silvia Polidoro 0 Giovanni Fiorito 5 6 Gianluca Campanella 4 Carlotta Sacerdot 3 eAmalia Mattiell 8 o Giovanna Masala 7 Claudia Agnol i Graziella Frasc a

Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation

Several studies have recently identified strong epigenetic signals related to tobacco smoking. However, an aspect that did not receive much attention is the evolution of epigenetic changes with time since smoking cessation. We conducted a series of epigenome-wide association studies to capture the dynamics of smoking-induced epigenetic changes after smoking cessation, using...

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

Background Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obtained before onset of the disease is associated with increased risk of breast cancer. We report on three independent prospective nested case-control studies from...

Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

Background DNA methylation profiles are responsive to environmental stimuli and metabolic shifts. This makes DNA methylation a potential biomarker of environmental-related and lifestyle-driven diseases of adulthood. Therefore, we investigated if white blood cells’ (WBCs) DNA methylation profiles are associated with myocardial infarction (MI) occurrence. Whole-genome DNA...

Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking

A single cytosine–guanine dinucleotide (CpG) site within coagulation factor II (thrombin) receptor-like 3 (F2RL3) was recently found to be hypomethylated in peripheral blood genomic DNA from smokers compared with former and non-smokers. We performed two epigenome-wide association studies (EWAS) nested in a prospective healthy cohort using the Illumina 450K Methylation Beadchip...

The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort

Background In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS...

Association Between Total Number of Deaths, Diabetes Mellitus, Incident Cancers, and Haplotypes in Chromosomal Region 8q24 in a Prospective Study

, Silvia Polidoro, Alessandra Allione, Fabio Rosa, Floriana Voglino, Rossana Critelli, Alessia Russo, Paolo Vineis, Giuseppe Matullo); Department of Genetics, Biology, and Biochemistry, University of Torino ... the prospective study and wrote the manuscript; Simonetta Guarrera, Silvia Polidoro, Alessandra Allione, Rossana Critelli, and Alessia Russo performed laboratory analyses; Giuseppe Matullo coordinated

Exome-Wide Association Study of Endometrial Cancer in a Multiethnic Population

Endometrial cancer (EC) contributes substantially to total burden of cancer morbidity and mortality in the United States. Family history is a known risk factor for EC, thus genetic factors may play a role in EC pathogenesis. Three previous genome-wide association studies (GWAS) have found only one locus associated with EC, suggesting that common variants with large effects may...

A Field Synopsis on Low-Penetrance Variants in DNA Repair Genes and Cancer Susceptibility

, University of Ioannina School of Medicine , Ioannina 45110, Greece ( 1 Paolo Vineis, Maurizio Manuguerra, Fotini K. Kavvoura, Simonetta Guarrera, Alessandra Allione, Fabio Rosa, Alessandra Di Gregorio, Silvia ... Polidoro, Federica Saletta, John P. A. Ioannidis, Giuseppe Matullo Background Several genes encoding for DNA repair molecules implicated in maintaining genomic integrity have been proposed as cancer

Methylome Analysis and Epigenetic Changes Associated with Menarcheal Age

with Menarcheal Age Christiana A. Demetriou Jia Chen Silvia Polidoro Karin van Veldhoven Cyrille Cuenin Gianluca Campanella Kevin Brennan Fran coise Clavel-Chapelon Laure Dossus Marina Kvaskoff Dagmar

Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer

The objective is to investigate the relationships between fruit and vegetable intake, DNA repair gene polymorphisms and the risk of bladder cancer. We have analyzed a hospital-based case–control study of 266 individuals with incident, histologically confirmed bladder cancer diagnosed between 1994 and 2003. Controls (n = 193) were patients treated for benign diseases recruited...

Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer

Risk factors for gastric cancer (GC) include inter-individual variability in the inflammatory response to Helicobacter pylori infection, in the ability of detoxifying DNA reactive species and repairing DNA damage generated by oxidative stress and dietary carcinogens. To evaluate the association between polymorphic DNA repair genes and GC risk, a case–control study including 314...

Sources of Pre-Analytical Variations in Yield of DNA Extracted from Blood Samples: Analysis of 50,000 DNA Samples in EPIC

Lund Roberto Bilbao Nu ria Sala Aurelio Barricarte Domenico Palli Carmen Navarro Salvatore Panico Maria Luisa Redondo Silvia Polidoro Laure Dossus Marie Christine Boutron- Ruault Franc oise Clavel

XRCC1, XRCC3, XPD gene polymorphisms, smoking and 32P-DNA adducts in a sample of healthy subjects

DNA repair genes have an important role in protecting individuals from cancer-causing agents. Polymorphisms in several DNA repair genes have been identified and individuals with non-dramatic reductions in the capacity to repair DNA damage are observed in the population, but the impact of specific genetic variants on repair phenotype and cancer risk has not yet been clarified. In...

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene

Kvetoslava Koppova Paolo Vineis Silvia Polidoro Simonetta Guarrera Carlotta Sacerdote Angeles Panadero Jose I. Sanz-Velez Manuel Sanchez Gabriel Valdivia Maria D. Garcia-Prats Jan G. Hengstler Silvia Selinski