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Simple changes of individual studies can improve the reproducibility of the biomedical scientific process as a whole

. Supervision: Gilbert SchoÈnfelder. Validation: Matthias Steinfath, Silvia Vogl, Norman Violet, Hans Mielke, Thomas Selhorst, Matthias Greiner. 18 / 20 Visualization: Silvia Vogl, Norman Violet, Franziska ... Schwarz. Writing ± original draft: Matthias Steinfath, Silvia Vogl, Norman Violet, Gilbert SchoÈnfelder. Writing ± review & editing: Matthias Steinfath, Silvia Vogl, Norman Violet, Gilbert SchoÈnfelder

CYP2C9 Genotype vs. Metabolic Phenotype for Individual Drug Dosing—A Correlation Analysis Using Flurbiprofen as Probe Drug

Currently, genotyping of patients for polymorphic enzymes responsible for metabolic elimination is considered a possibility to adjust drug dose levels. For a patient to profit from this procedure, the interindividual differences in drug metabolism within one genotype should be smaller than those between different genotypes. We studied a large cohort of healthy young adults (283...