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Cross-sectional estimates revealed high HIV incidence in Botswana rural communities in the era of successful ART scale-up in 2013-2015

Novitsky. Formal analysis: Sikhulile Moyo, Simani Gaseitsiwe, Vlad Novitsky. Funding acquisition: Shahin Lockman, Max Essex. Investigation: Sikhulile Moyo, Simani Gaseitsiwe, Terence Mohammed, Molly ... , Madisa Mine, Refeletswe Lebelonyane, Kathleen E. Wirth, Janet Moore, Shahin Lockman, Joseph M. Makhema, Max Essex, Vlad Novitsky. Project administration: Simani Gaseitsiwe, Etienne Kadima Yankinda, Unoda

Immunological non-response and low hemoglobin levels are predictors of incident tuberculosis among HIV-infected individuals on Truvada-based therapy in Botswana

Conceptualization: Lucy Mupfumi, Sikhulile Moyo, Rosemary M. Musonda, Simani Gaseitsiwe. Data curation: Joseph Makhema, Ric Marlink. Formal analysis: Lucy Mupfumi, Sikhulile Moyo, Kesaobaka Molebatsi, Prisca K ... . Thami. Supervision: Sikhulile Moyo, Ishmael Kasvosve, Rosemary M. Musonda, Simani Gaseitsiwe. Writing ± original draft: Lucy Mupfumi. Writing ± review & editing: Prisca K. Thami, Motswedi Anderson, Tuelo

Deciphering Multiplicity of HIV-1C Infection: Transmission of Closely Related Multiple Viral Lineages

Background A single viral variant is transmitted in the majority of HIV infections. However, about 20% of heterosexually transmitted HIV infections are caused by multiple viral variants. Detection of transmitted HIV variants is not trivial, as it involves analysis of multiple viral sequences representing intra-host HIV-1 quasispecies. Methodology We distinguish two types of...

Analysis of Viral Diversity in Relation to the Recency of HIV-1C Infection in Botswana

Engelbrecht 0 Simani Gaseitsiwe Kenanao P. Kotokwe Rosemary Musonda Frank Tanser Max Essex Vladimir Novitsky Tulio de Oliveira 0 Division of Medical Virology, Stellenbosch University , Tygerberg , South Africa

Molecular characterisation of hepatitis B virus in HIV-1 subtype C infected patients in Botswana

Background Hepatitis B virus (HBV) is a major global health problem especially in sub-Saharan Africa and in East Asia. Ten hepatitis B virus genotypes have been described that differ by geographic distribution, disease progression, and response to treatment. Escape mutations within the surface open reading frame (ORF) affect HBV antigenicity leading to failures in diagnosis...

Whole CMV Proteome Pattern Recognition Analysis after HSCT Identifies Unique Epitope Targets Associated with the CMV Status

Cytomegalovirus (CMV) infection represents a vital complication after Hematopoietic Stem Cell Transplantation (HSCT). We screened the entire CMV proteome to visualize the humoral target epitope-focus profile in serum after HSCT. IgG profiling from four patient groups (donor and/or recipient +/− for CMV) was performed at 6, 12 and 24 months after HSCT using microarray slides...

Pattern Recognition in Pulmonary Tuberculosis Defined by High Content Peptide Microarray Chip Analysis Representing 61 Proteins from M. tuberculosis

Background Serum antibody-based target identification has been used to identify tumor-associated antigens (TAAs) for development of anti-cancer vaccines. A similar approach can be helpful to identify biologically relevant and clinically meaningful targets in M.tuberculosis (MTB) infection for diagnosis or TB vaccine development in clinically well defined populations. Method We...

Highly Active Antiretroviral Therapy Started during Pregnancy or Postpartum Suppresses HIV-1 RNA, but Not DNA, in Breast Milk

BackgroundThe ability of highly active antiretroviral therapy (HAART) to reduce human immunodeficiency virus type 1 (HIV-1) RNA and DNA in breast milk has not been described MethodsWe compared breast-milk HIV-1 RNA and DNA loads of women in Botswana who received HAART (nevirapine, lamivudine, and zidovudine) and women who did not receive HAART ResultsWomen in the HAART group...