, 560 Ray C. Hunt Drive, Charlottesville, VA, 22903, USA Hardik I. Parikh Duke Molecular Physiology Institute, Duke University School of Medicine, 300 N Duke St, Durham, NC, 27701, USA Simon G. Gregory ... author publications You can also search for this author in PubMed Google Scholar Simon G. Gregory View author publications You can also search for this author in PubMed Google Scholar C. Sue
. Bartlett Corey R. Hart Jason R. Gibson Ian R. Lanza Virginia B. Kraus Simon G. Gregory Bruce M. Spiegelman James P. White In the version of this article initially published, the name of author Corey R. Hart
Changes in platelet physiology are associated with simultaneous changes in microRNA concentrations, suggesting a role for microRNA in platelet regulation. Here we investigated potential associations between microRNA and platelet reactivity (PR), a marker of platelet function, in two cohorts following a non-ST elevation acute coronary syndrome (NSTE-ACS) event. First, non-targeted...
The immune system plays a multifunctional role throughout the regenerative process, regulating both pro-/anti-inflammatory phases and progenitor cell function. In the present study, we identify the myokine/cytokine Meteorin-like (Metrnl) as a critical regulator of muscle regeneration. Mice genetically lacking Metrnl have impaired muscle regeneration associated with a reduction in...
Kemeny, Michael R. Zalutsky, Kathryn Ware, Thomas Ribar, Paraskevi Giannakakou, Jiaren Zhang, Drew Gerber, Wen-Chi Foo, Susan Halabi, Simon G. Gregory. Funding acquisition: Andrew J. Armstrong ... , Susan Halabi, Simon G. Gregory. Visualization: Andrew J. Armstrong, Santosh Gupta, Simon G. Gregory. Writing ? original draft: Andrew J. Armstrong, Santosh Gupta, Michael R. Zalutsky, Jason A. Somarelli
Survival bias may unduly impact genetic association with complex diseases; gene-specific survival effects may further complicate such investigations. Coronary artery disease (CAD) is a complex phenotype for which little is understood about gene-specific survival effects; yet, such information can offer insight into refining genetic associations, improving replications, and can...
Background Expression quantitative trait loci (eQTL) play an important role in the regulation of gene expression. Gene expression levels and eQTLs are expected to vary from tissue to tissue, and therefore multi-tissue analyses are necessary to fully understand complex genetic conditions in humans. Dura mater tissue likely interacts with cranial bone growth and thus may play a...
Garrett1, 3, Heidi Cope1, 3, Christina A Markunas1, Herbert Fuchs4, Gerald Grant4, 5, David B Dunson2, Simon G Gregory†1, 6 and Allison E Ashley-Koch†1, 3Email author †Contributed equally BMC ... ) pathways. Notes Simon G Gregory and Allison E Ashley-Koch contributed equally to this work. Abbreviations (eQTL): Expression Quantitative Trait Loci (CMI): Chiari Type I Malformation (SNP
Background Chiari Type I Malformation (CMI) is characterized by herniation of the cerebellar tonsils through the foramen magnum at the base of the skull, resulting in significant neurologic morbidity. As CMI patients display a high degree of clinical variability and multiple mechanisms have been proposed for tonsillar herniation, it is hypothesized that this heterogeneous...
Markunas1, Eric Lock1, Karen Soldano1, 2, Heidi Cope1, 2, Chien-Kuang C Ding1, David S Enterline3, Gerald Grant4, Herbert Fuchs5, Allison E Ashley-Koch†1, 2 and Simon G Gregory†1, 6Email author †Contributed ... investigation. Biological characterization of the blood classes identified a gene expression profile that corresponded to a global down-regulation in protein synthesis. Notes Allison E Ashley-Koch and Simon G
Air pollution is a worldwide contributor to cardiovascular disease mortality and morbidity. Traffic-related air pollution is a widespread environmental exposure and is associated with multiple cardiovascular outcomes such as coronary atherosclerosis, peripheral arterial disease, and myocardial infarction. Despite the recognition of the importance of both genetic and environmental...
Chiari Type I Malformation (CMI) is characterized by displacement of the cerebellar tonsils below the base of the skull, resulting in significant neurologic morbidity. Although multiple lines of evidence support a genetic contribution to disease, no genes have been identified. We therefore conducted the largest whole genome linkage screen to date using 367 individuals from 66...
There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We performed race-stratified...
Given the importance of cardiovascular disease (CVD) to public health and the demonstrated heritability of both disease status and its related risk factors, identifying the genetic variation underlying these susceptibilities is a critical step in understanding the pathogenesis of CVD and informing prevention and treatment strategies. Although one can look for genetic variation...
Transcription factors are key mediators of human complex disease processes. Identifying the target genes of transcription factors will increase our understanding of the biological network leading to disease risk. The prediction of transcription factor binding sites (TFBSs) is one method to identify these target genes; however, current prediction methods need improvement. We chose...
Transcription factors are key mediators of human complex disease processes. Identifying the target genes of transcription factors will increase our understanding of the biological network leading to disease risk. The prediction of transcription factor binding sites (TFBSs) is one method to identify these target genes; however, current prediction methods need improvement. We chose...
Background Existing literature indicates that ADRB2 gene is associated with health and longevity, but none of previous studies investigated associations of carrying the ADRB2 minor alleles and interactions between ADRB2 genotypes and social/behavioral factors(GxE) with health outcomes at advanced ages. This study intends to fill in this research gap. Method We conducted an...
We studied the status of chromosomes 1 and 19 in 363 astrocytic and oligodendroglial tumors. Whereas the predominant pattern of copy number abnormality was a concurrent loss of the entire 1p and 19q regions (total 1p/19q loss) among oligodendroglial tumors and partial deletions of 1p and/or 19q in astrocytic tumors, a subset of apparently astrocytic tumors also had total 1p/19q...
Glioblastoma multiforme (GBM) is one of the deadliest tumors afflicting humans, and the mechanisms of its onset and progression remain largely undefined. Our attempts to elucidate its molecular pathogenesis through DNA copy-number analysis by genome-wide digital karyotyping and single nucleotide polymorphism arrays identified a dramatic focal amplification on chromosome 1q32 in 4...
Smooth muscle cell (SMC) proliferation is a hallmark of vascular injury and disease. Global hypomethylation occurs during SMC proliferation in culture and in vivo during neointimal formation. Regardless of the programmed or stochastic nature of hypomethylation, identifying these changes is important in understanding vascular disease, as maintenance of a cells' epigenetic profile...
