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8 papers found.
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Apolipoprotein E genotype does not moderate the associations of depressive symptoms, neuroticism and allostatic load with cognitive ability and cognitive aging in the Lothian Birth Cohort 1936

: Zander Crook, Tom Booth, Simon R. Cox, John M. Starr, Ian J. Deary. Resources: Tom Booth. Supervision: Tom Booth, Ian J. Deary. Validation: Zander Crook. Visualization: Zander Crook, Tom Booth. 16 / 20 ... Writing ± original draft: Zander Crook, Tom Booth. Writing ± review & editing: Zander Crook, Tom Booth, Simon R. Cox, Janie Corley, Dominika Dykiert, Paul Redmond, Alison Pattie, Adele M. Taylor, Sarah E

A latent measure explains substantial variance in white matter microstructure across the newborn human brain

A latent measure of white matter microstructure (g WM) provides a neural basis for information processing speed and intelligence in adults, but the temporal emergence of g WM during human development is unknown. We provide evidence that substantial variance in white matter microstructure is shared across a range of major tracts in the newborn brain. Based on diffusion MRI scans...

Single Nucleotide Polymorphisms Associated with Reading Ability Show Connection to Socio-Economic Outcomes

, Saskia P. Hagenaars, Simon R. Cox, William David Hill, Gail Davies, Sarah E. Harris, Ian J. Deary, David M. Evans, Nicholas G. Martin, Margaret J. Wright, and Timothy C. Bates declare that they have no

Brain cortical characteristics of lifetime cognitive ageing

, UK 1 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh , 7 George Square, Edinburgh EH8 9JZ , UK 2 & Simon R. Cox 3 Division of Psychiatry, University of Edinburgh

Trait conscientiousness and the personality meta-trait stability are associated with regional white matter microstructure

Establishing the neural bases of individual differences in personality has been an enduring topic of interest. However, while a growing literature has sought to characterize grey matter correlates of personality traits, little attention to date has been focused on regional white matter correlates of personality, especially for the personality traits agreeableness...

Risk and protective factors for structural brain ageing in the eighth decade of life

Individuals differ markedly in brain structure, and in how this structure degenerates during ageing. In a large sample of human participants (baseline n = 731 at age 73 years; follow-up n = 488 at age 76 years), we estimated the magnitude of mean change and variability in changes in MRI measures of brain macrostructure (grey matter, white matter, and white matter hyperintensity...

Brain white matter structure and information processing speed in healthy older age

Cognitive decline, especially the slowing of information processing speed, is associated with normal ageing. This decline may be due to brain cortico-cortical disconnection caused by age-related white matter deterioration. We present results from a large, narrow age range cohort of generally healthy, community-dwelling subjects in their seventies who also had their cognitive...

DNA methylation age of blood predicts all-cause mortality in later life

Jude Gibson Anjali K Henders Paul Redmond Simon R Cox 1 Alison Pattie Janie Corley Lee Murphy Nicholas G Martin Grant W Montgomery Andrew P Feinberg M Daniele Fallin Michael L Multhaup Andrew E Jaffe