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Effect of antioxidant and anti-inflammatory on bioactive components of carrot (Daucus carota L.) leaves from Jeju Island

University , Jeju 63243 , Republic of Korea 2 Subtropical/tropical organism gene bank, Jeju National University , Jeju 63243 , Republic of Korea 3 Somi Kim Cho The present study evaluated the potential of

Effects of the drying method and extraction solvent on antioxidant and anti-inflammatory activity of Melosira nummuloides bioproducts

, College of Applied Life Sciences, Jeju National University , Jeju 63243 , Republic of Korea 5 Somi Kim Cho Melosira nummuloides is a marine diatom with potential use as food, fuel, and a dietary supplement

Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency

Korea Dong Il Choi, Myeongwon Kim, Somi Kim, Nam-Kyung Yu, Chuljung Kwak & Bong-Kiun Kaang Laboratory for Behavioral Neural Circuitry and Physiology, Department of Anatomy, Brain Science and Engineering ... search for this author in PubMed Google Scholar Myeongwon Kim View author publications You can also search for this author in PubMed Google Scholar Somi Kim View author publications You can also

Epigenetic regulation and chromatin remodeling in learning and memory

Natural Sciences, Seoul National University, Seoul, Republic of KoreaSomi Kim & Bong-Kiun Kaang AuthorsSearch for Somi Kim in:Nature Research journals • PubMed • Google ScholarSearch for Bong-Kiun Kaang

CTCF as a multifunctional protein in genome regulation and gene expression

Sciences, Seoul National University, Seoul, KoreaSomi Kim, Nam-Kyung Yu & Bong-Kiun Kaang AuthorsSearch for Somi Kim in:Nature Research journals • PubMed • Google ScholarSearch for Nam-Kyung Yu in:Nature

Quercetin Induces Mitochondrial Mediated Apoptosis and Protective Autophagy in Human Glioblastoma U373MG Cells

Quercetin is a dietary flavonoid with known antitumor effects against several types of cancers by promoting apoptotic cell death and inducing cell cycle arrest. However, U373MG malignant glioma cells expressing mutant p53 are resistant to a 24 h quercetin treatment. In this study, the anticancer effect of quercetin was reevaluated in U373MG cells, and quercetin was found to be...

Quercetin Induces Mitochondrial Mediated Apoptosis and Protective Autophagy in Human Glioblastoma U373MG Cells

Quercetin is a dietary flavonoid with known antitumor effects against several types of cancers by promoting apoptotic cell death and inducing cell cycle arrest. However, U373MG malignant glioma cells expressing mutant p53 are resistant to a 24 h quercetin treatment. In this study, the anticancer effect of quercetin was reevaluated in U373MG cells, and quercetin was found to be...

Quercetin Induces Mitochondrial Mediated Apoptosis and Protective Autophagy in Human Glioblastoma U373MG Cells

Quercetin is a dietary flavonoid with known antitumor effects against several types of cancers by promoting apoptotic cell death and inducing cell cycle arrest. However, U373MG malignant glioma cells expressing mutant p53 are resistant to a 24 h quercetin treatment. In this study, the anticancer effect of quercetin was reevaluated in U373MG cells, and quercetin was found to be...

Quercetin Induces Mitochondrial Mediated Apoptosis and Protective Autophagy in Human Glioblastoma U373MG Cells

Quercetin is a dietary flavonoid with known antitumor effects against several types of cancers by promoting apoptotic cell death and inducing cell cycle arrest. However, U373MG malignant glioma cells expressing mutant p53 are resistant to a 24 h quercetin treatment. In this study, the anticancer effect of quercetin was reevaluated in U373MG cells, and quercetin was found to be...

Wogonin suppresses stem cell-like traits of CD133 positive osteosarcoma cell via inhibiting matrix metallopeptidase-9 expression

Several efforts have been deployed to cure osteosarcoma, a high-grade malignant bone tumour in children and adolescents. However, some challenges such as drug resistance, relapse, and tumour metastasis remain owing to the existence of cancer stem cells (CSC). There is an urgent need to develop cost-effective and safe therapies. Wogonin, an extract from the root of Scutellaria...

Wogonin suppresses stem cell-like traits of CD133 positive osteosarcoma cell via inhibiting matrix metallopeptidase-9 expression

Several efforts have been deployed to cure osteosarcoma, a high-grade malignant bone tumour in children and adolescents. However, some challenges such as drug resistance, relapse, and tumour metastasis remain owing to the existence of cancer stem cells (CSC). There is an urgent need to develop cost-effective and safe therapies. Wogonin, an extract from the root of Scutellaria...

Impaired learning and memory in CD38 null mutant mice

CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca 2+ from intracellular stores. Recently, CD38 has been shown to regulate oxytocin release from hypothalamic neurons. Importantly, CD38 mutations are associated with autism spectrum disorders (ASD) and CD38...

Impaired learning and memory in CD38 null mutant mice

CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca2+ from intracellular stores. Recently, CD38 has been shown to regulate oxytocin release from hypothalamic neurons. Importantly, CD38 mutations are associated with autism spectrum disorders (ASD) and CD38...

PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory

Lysine-specific demethylase 1 (LSD1) is a histone demethylase that participates in transcriptional repression or activation. Recent studies reported that LSD1 is involved in learning and memory. Although LSD1 phosphorylation by PKCα was implicated in circadian rhythmicity, the importance of LSD1 phosphorylation in learning and memory is unknown. In this study, we examined the...