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Microdialysis and ultrasound elastography for monitoring of localized muscular reaction after pharmacological stimulation in rats

ObjectiveHalothane and caffeine are known to cause skeletal muscular contractions in vitro and have been proven to induce circumscribed metabolic reactions when injected into rat skeletal muscle. In this study 26 rats were investigated by either continuous application of calcium 160 mM or bolus injection of caffeine 160 mM or halothane 10% vol via a microdialysis probe in the...

Management of malignant hyperthermia: diagnosis and treatment

Management of malignant hyperthermia: diagnosis and treatment Daniel Schneiderbanger, Stephan Johannsen, Norbert Roewer, Frank SchusterDepartment of Anaesthesia and Critical Care, University of

Evaluation of suspected malignant hyperthermia events during anesthesia

Background Malignant hyperthermia (MH), a metabolic myopathy triggered by volatile anesthetics and depolarizing muscle relaxants, is a potentially lethal complication of general anesthesia in susceptible patients. The implementation of modern inhalation anesthetics that research indicates as less potent trigger substances and the recommended limitations of succinylcholine use...

The effect of succinylcholine on malignant hyperthermia events in susceptible swine

Background While the impact of volatile anaesthetics to induce malignant hyperthermia (MH) is abundantly clear, the role of succinylcholine still remains controversial. To evaluate the influence of succinylcholine on porcine MH events, the authors investigated the hemodynamic and metabolic responses in MH susceptible (MHS) and non-susceptible (MHN) swine following either...

In Vitro Contracture Test Results and Anaesthetic Management of a Patient with Emery-Dreifuss Muscular Dystrophy for Cardiac Transplantation

 Stephan Johannsen,1 Marc Lazarus,1 Ivan Aleksic,3 Rainer Leyh,3 and Norbert Roewer1 1Department of Anaesthesia and Critical Care, University of Wuerzburg, 97080 Wuerzburg, Germany 2Department of Neurology

Functional and genetic characterization of clinical malignant hyperthermia crises: a multi-centre study

Background Malignant hyperthermia (MH) is a rare pharmacogenetic disorder which is characterized by life-threatening metabolic crises during general anesthesia. Classical triggering substances are volatile anesthetics and succinylcholine (SCh). The molecular basis of MH is excessive release of Ca2+ in skeletal muscle principally by a mutated ryanodine receptor type 1 (RyR1). To...