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The importance of endpoint selection: How effective does a drug need to be for success in a clinical trial of a possible Alzheimer’s disease treatment?

To date, Alzheimer’s disease (AD) clinical trials have been largely unsuccessful. Failures have been attributed to a number of factors including ineffective drugs, inadequate targets, and poor trial design, of which the choice of endpoint is crucial. Using data from the Alzheimer’s Disease Neuroimaging Initiative, we have calculated the minimum detectable effect size (MDES) in...

Exploring regulatory networks of miR-96 in the developing inner ear

1SA, UKMorag A. Lewis, Annalisa Buniello, Jennifer M. Hilton, Fei Zhu, William I. Zhang, Stephanie Evans & Karen P. SteelEMBL EBI, Hinxton, Cambridge CB10 1SD.Stijn van Dongen & Anton J. Enright ... Stephanie Evans in:Nature Research journals • PubMed • Google ScholarSearch for Stijn van Dongen in:Nature Research journals • PubMed • Google ScholarSearch for Anton J. Enright in:Nature Research journals