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Neonatal and maternal outcomes of successful manual rotation to correct malposition of the fetal head; A retrospective and prospective observational study

Objective To evaluate the neonatal and maternal outcomes associated with successful operative vaginal births assisted by manual rotation. Design Prospective and retrospective observational study. Setting Delivery suite in a tertiary referral teaching hospital in England. Population A cohort of 2,426 consecutive operative births, in the second stage of labour, complicated with...

A Review of A Priori Regression Models for Warfarin Maintenance Dose Prediction

A number of a priori warfarin dosing algorithms, derived using linear regression methods, have been proposed. Although these dosing algorithms may have been validated using patients derived from the same centre, rarely have they been validated using a patient cohort recruited from another centre. In order to undertake external validation, two cohorts were utilised. One cohort...

Thoracic Epidural analgesia versus Rectus Sheath Catheters for open midline incisions in major abdominal surgery within an enhanced recovery programme (TERSC): study protocol for a randomised controlled trial

Background Thoracic epidural analgesia (TEA) is recommended for post-operative pain relief in patients undergoing major abdominal surgery via a midline incision. However, the effectiveness of TEA is variable with high failure rates reported post-operatively. Common side effects such as low blood pressure and motor block can reduce mobility and hinder recovery, and a number of...

Book Reviews

Grove, IL: InterVarsity Press 2010, 373 pp., paper, $27.00 ISBN: 978-0-8308-2722-0 Reviewed by Steven Lane Leithart’s Defending Constantine is a multi-faceted work that walks the line between history

Household Tobacco Smoke and Admission Weight Predict Severe Bronchiolitis in Infants Independent of Deprivation: Prospective Cohort Study

Objectives To examine demographic, environmental and clinical factors associated with severe bronchiolitis in infants admitted to hospital and quantify the independent effects of these factors. Design Prospective cohort study. Setting Alder Hey Children's Hospital, Liverpool, United Kingdom. Participants 378 infants admitted to hospital with a diagnosis of bronchiolitis, of whom...

Electronic brachytherapy as adjuvant therapy for early stage breast cancer: a retrospective analysis

15 n azha cancer center , n orthfield, n J, UsA 16 Brockton hospital , Brockton, MA, UsA , USA PowerdbyTCPDF(ww.tcpdf.org) gary schreiber 4 Tapan roy 5 gary Proulx 6 susan Laduzinsky 7 steven Lane 8

Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I131 KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma

Background Advanced pancreatic cancer has a poor prognosis, and the current standard of care (gemcitabine based chemotherapy) provides a small survival advantage. However the drawback is the accompanying systemic toxicity, which targeted treatments may overcome. This study aimed to evaluate the safety and tolerability of KAb201, an anti-carcinoembryonic antigen monoclonal...