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Candida dubliniensis: An Appraisal of Its Clinical Significance as a Bloodstream Pathogen

A nine-year prospective study (2002–2010) on the prevalence of Candida dubliniensis among Candida bloodstream isolates is presented. The germ tube positive isolates were provisionally identified as C. dubliniensis by presence of fringed and rough colonies on sunflower seed agar. Subsequently, their identity was confirmed by Vitek2 Yeast identification system and/or by...

Coenzyme Q 10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress

Background Coenzyme Q 10 (CoQ 10 ) supplementation improves mitochondrial coupling of respiration to oxidative phosphorylation, decreases superoxide production in endothelial cells, and may improve functional cardiac capacity in patients with congestive heart failure. There are no studies evaluating the safety, tolerability and efficacy of varying doses of CoQ 10 in chronic...

Comparative evaluation of INNO-LiPA HBV assay, direct DNA sequencing and subtractive PCR-RFLP for genotyping of clinical HBV isolates

Maisa M Ali 0 Fuad Hasan Suhail Ahmad 0 Widad Al-Nakib 0 0 Department of Microbiology, Faculty of Medicine, Health Sciences Center, Kuwait University , Kuwait Genotypes (A to H) of hepatitis B

Development of a Novel Inhalational Model of Invasive Pulmonary Aspergillosis in Rats and Comparative Evaluation of Three Biomarkers for Its Diagnosis

Aspergillus fumigatus, a thermotolerant fungus, is the main causative agent of invasive pulmonary aspergillosis (IPA) in immunocompromised patients that is associated with high mortality rates. Early diagnosis of IPA is crucial for mortality reduction and improved prognosis. An experimental inhalational model of IPA was developed in rats and the efficacy of three biomarkers...

Discordance across Phenotypic and Molecular Methods for Drug Susceptibility Testing of Drug-Resistant Mycobacterium tuberculosis Isolates in a Low TB Incidence Country

With increasing incidence of multidrug-resistant tuberculosis (MDR-TB), accurate drug susceptibility testing (DST) of Mycobacterium tuberculosis to first-line drugs has become crucial for proper patient management. We evaluated concordance of DST results for 70 M. tuberculosis isolates across two phenotypic and two molecular methods: BACTEC 460TB, MGIT 960 system, GenoType...

Echoviruses are a major cause of aseptic meningitis in infants and young children in Kuwait

Background The etiologic agents of aseptic meningitis (AM) often include human enteroviruses. The role of enteroviruses causing AM in young children was investigated during a 3-year period in Kuwait. Results Enteroviral RNA was detected in cerebrospinal fluid (CSF) by reverse transcription-PCR and specific genotypes of enteroviruses were identified by direct DNA sequencing of VP4...

First report of molecular detection of fluoroquinolone resistance-associated gyrA mutations in multidrug-resistant clinical Mycobacterium tuberculosis isolates in Kuwait

Al-Mutairi 0 Suhail Ahmad 0 Eiman Mokaddas 0 0 Department of Microbiology, Faculty of Medicine, Kuwait University , Kuwait Background: Nearly 5% of all Mycobacterium tuberculosis strains worldwide

Increasing prevalence, molecular characterization and antifungal drug susceptibility of serial Candida auris isolates in Kuwait

Omar Al-Musallam for technical assistance. Author Contributions Conceptualization: Ziauddin Khan, Suhail Ahmad, Noura Al-Sweih. Data curation: Suhail Ahmad, Leena Joseph, Wadha Alfouzan, Mohammad ... Asadzadeh. Formal analysis: Ziauddin Khan, Suhail Ahmad, Leena Joseph, Mohammad Asadzadeh. Funding acquisition: Ziauddin Khan. Investigation: Suhail Ahmad, Leena Joseph. Project administration: Ziauddin

Isolation of Lodderomyces elongisporus from the Catheter Tip of a Fungemia Patient in the Middle East

Academic Editor: Jacques F. Meis Copyright © 2013 Suhail Ahmad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use

Isolation of cholesterol-dependent, multidrug-resistant Candida glabrata strains from blood cultures of a candidemia patient in Kuwait

Background Candida glabrata has emerged as an important human pathogen associated with systemic and mucosal infections. Here, we describe isolation of two cholesterol-dependent Candida glabrata strains from a candidemia patient which failed to grow on the media devoid of a cholesterol source. Methods Both the isolates were recovered from BACTEC Plus Aerobic/F blood culture...

Levels of (1→3)-β-D-glucan, Candida mannan and Candida DNA in serum samples of pediatric cancer patients colonized with Candida species

Zia U Khan 0 Suhail Ahmad 0 0 Department of Microbiology, Faculty of Medicine, Kuwait University , Safat, 13110. P. O. Box 24923 , Kuwait 1 NBK Cancer Ward, Al-Sabah Hospital , Kuwait Background

Minor contribution of mutations at iniA codon 501 and embC-embA intergenic region in ethambutol-resistant clinical Mycobacterium tuberculosis isolates in Kuwait

Background Ethambutol (EMB) is a first-line drug for the treatment of tuberculosis (TB). Resistance to EMB in Mycobacterium tuberculosis isolates is mediated by mutations in several genes involved in arabinan synthesis notably three emb (arabinosyl transferase) and iniA (isoniazid-inducible) genes. Most epidemiologically unrelated EMB-resistant M. tuberculosis strains contain...

Molecular identification and antifungal susceptibility profile of Aspergillus flavus isolates recovered from clinical specimens in Kuwait

Background Within the genus Aspergillus, A. flavus is the second most important species of clinical significance. It is predominantly associated with infections involving sinuses, eye and skin, mostly in geographic regions with hot and arid climate, including the Middle East. Recent reports on emergence of resistance to triazoles among Aspergillus spp. is a cause of concern for...

New approaches in the diagnosis and treatment of latent tuberculosis infection

With nearly 9 million new active disease cases and 2 million deaths occurring worldwide every year, tuberculosis continues to remain a major public health problem. Exposure to Mycobacterium tuberculosis leads to active disease in only ~10% people. An effective immune response in remaining individuals stops M. tuberculosis multiplication. However, the pathogen is completely...

Pathogenesis, Immunology, and Diagnosis of Latent Mycobacterium tuberculosis Infection

, Kuwait Received 6 September 2010; Accepted 28 October 2010 Academic Editor: James Triccas Copyright © 2011 Suhail Ahmad. This is an open access article distributed under the Creative Commons

Performance comparison of phenotypic and molecular methods for detection and differentiation of Candida albicans and Candida dubliniensis

Background Candida albicans is the most pathogenic Candida species but shares many phenotypic features with Candida dubliniensis and may, therefore, be misidentified in clinical microbiology laboratories. Candidemia cases due to C. dubliniensis are increasingly being reported in recent years. Accurate identification is warranted since mortality rates are highest for C. albicans...

Population structure and molecular genetic characterization of 5-flucytosine-susceptible and -resistant clinical Candida dubliniensis isolates from Kuwait

Candida dubliniensis and Candida albicans are two closely related species. Although C. dubliniensis is less pathogenic, it has a higher propensity to develop resistance to fluconazole and some strains exhibit intrinsic resistance to 5-flucytosine (5-FC). All 5-FC-resistant isolates from Kuwait were previously shown to belong to one of seven internal transcribed spacer (ITS...

Population structure and molecular genetic characterization of clinical Candida tropicalis isolates from a tertiary-care hospital in Kuwait reveal infections with unique strains

Conceptualization: Suhail Ahmad, Ziauddin Khan. Data curation: Khaled Al-Obaid, Mohammad Asadzadeh, Ziauddin Khan. 12 / 16 Formal analysis: Khaled Al-Obaid, Mohammad Asadzadeh, Suhail Ahmad, Ziauddin Khan. Funding ... acquisition: Suhail Ahmad, Ziauddin Khan. Investigation: Khaled Al-Obaid, Mohammad Asadzadeh. Methodology: Khaled Al-Obaid, Mohammad Asadzadeh. Project administration: Suhail Ahmad, Ziauddin Khan. Resources

Simple, Low-Cost Detection of Candida parapsilosis Complex Isolates and Molecular Fingerprinting of Candida orthopsilosis Strains in Kuwait by ITS Region Sequencing and Amplified Fragment Length Polymorphism Analysis

Candida parapsilosis has now emerged as the second or third most important cause of healthcare-associated Candida infections. Molecular studies have shown that phenotypically identified C. parapsilosis isolates represent a complex of three species, namely, C. parapsilosis, C. orthopsilosis and C. metapsilosis. Lodderomyces elongisporus is another species phenotypically closely...