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On the Utility of Short Echo Time (TE) Single Voxel 1H–MRS in Non–Invasive Detection of 2–Hydroxyglutarate (2HG); Challenges and Potential Improvement Illustrated with Animal Models Using MRUI and LCModel

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are frequently found in brain tumors, and the resulting onco–metabolite, 2–hydroxyglutarate (2HG), has been suggested to be a potential diagnostic and prognostic biomarker of the diseases. Indeed, recent studies have demonstrated the feasibility of non–invasively detecting 2HG by using proton magnetic resonance spectroscopy...

3D hand tracking using Kalman filter in depth space

Hand gestures are an important type of natural language used in many research areas such as human-computer interaction and computer vision. Hand gestures recognition requires the prior determination of the hand position through detection and tracking. One of the most efficient strategies for hand tracking is to use 2D visual information such as color and shape. However, visual...

Low-temperature synthesis of LiFePO4 nanocrystals by solvothermal route

LiFePO4 nanocrystals were synthesized at a very low temperature of 170°C using carbon nanoparticles by a solvothermal process in a polyol medium, namely diethylene glycol without any heat treatment as a post procedure. The powder X-ray diffraction pattern of the LiFePO4 was indexed well to a pure orthorhombic system of olivine structure (space group: Pnma) with no undesirable...

NILCO biomarkers in breast cancer from Chinese patients

Background Notch, IL-1 and leptin are known pro-angiogenic factors linked to breast cancer development, tumor aggressiveness and poor prognosis. A complex crosstalk between these molecules (NILCO) has been reported in breast cancer cell lines. However, whether NILCO biomarkers are differentially expressed in estrogen responsive (ER+), unresponsive (ER-) and triple negative (TNBC...

The N-Terminal Extension Domain of the C. elegans Half-Molecule ABC Transporter, HMT-1, Is Required for Protein-Protein Interactions and Function

Background Members of the HMT-1 (heavy metal tolerance factor 1) subfamily of the ATP-binding cassette (ABC) transporter superfamily detoxify heavy metals and have unique topology: they are half-molecule ABC transporters that, in addition to a single transmembrane domain (TMD1) and a single nucleotide-binding domain (NBD1), possess a hydrophobic NH2-terminal extension (NTE...

High-resolution genome-wide scan of genes, gene-networks and cellular systems impacting the yeast ionome

Background To balance the demand for uptake of essential elements with their potential toxicity living cells have complex regulatory mechanisms. Here, we describe a genome-wide screen to identify genes that impact the elemental composition (‘ionome’) of yeast Saccharomyces cerevisiae. Using inductively coupled plasma – mass spectrometry (ICP-MS) we quantify Ca, Cd, Co, Cu, Fe, K...

Endoplasmic Reticulum Aminopeptidase-1 Functions Regulate Key Aspects of the Innate Immune Response

Sarah Godbehere-Roosa 0 Sungjin Kim 0 Andrea Amalfitano 0 Jo rg Hermann Fritz, McGill University, Canada 0 Department of Microbiology and Molecular Genetics, Michigan State University , East Lansing

Noise reduction in genome-wide perturbation screens using linear mixed-effect models

Motivation: High-throughput perturbation screens measure the phenotypes of thousands of biological samples under various conditions. The phenotypes measured in the screens are subject to substantial biological and technical variation. At the same time, in order to enable high throughput, it is often impossible to include a large number of replicates, and to randomize their order...

Resource Partitioning with Beamforming for the Decode-Forward Relay Networks

Sungjin Kim 0 0 Communication and Network Laboratory, Samsung Advanced Institute of Technology , Mt. 14-1, Nongseo-Dong, Giheung-Gu, Yongin-Si, Gyeonggi-Do 446-712 , South Korea A joint power and time slot

Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12

While many cancers show a sex bias, the genetic basis and molecular mechanisms underlying sex bias are not always clear. Astrocytoma and glioblastoma show male predominance in humans. We have shown previously that glial tumors forming in the Nf1−/+; Trp53−/+cis (NPcis) mouse model also show a sex bias in some genetic contexts. Using cross-species comparisons we have identified...

Activation Mechanisms of Natural Killer Cells during Influenza Virus Infection

Elizabeth Gardner 0 Sungjin Kim 0 Ali A. Ashkar, McMaster University, Canada 0 1 Department of Microbiology and Molecular Genetics, Michigan State University , East Lansing, Michigan , United States of

Identification of human NK cells that are deficient for signaling adaptor FcRγ and specialized for antibody-dependent immune functions

NK cells respond to tumor and virus-infected cells directly through several activation receptors, including natural cytotoxicity receptors, or indirectly through the activating Fc receptor CD16 for antibody-coated cells. Triggering of NK-cell effector functions through these receptors depends on physically associated transmembrane signaling adaptors, such as FcRγ (also known as...

HPV-associated lung cancers: an international pooled analysis

Human papillomavirus (HPV) is the etiologic risk factor for cervical cancer. Some studies have suggested an association with a subset of lung tumors, but the etiologic link has not been firmly established. We performed an international pooled analysis of cross-sectional studies (27 datasets, n = 3249 patients) to evaluate HPV DNA prevalence in lung cancer and to investigate viral...

Light to Moderate Alcohol Consumption and Disability: Variable Benefits by Health Status

, California (Arun S. Karlamangla, Deborah M. Kado, Howard Dedes, Diana H. Liao, Sungjin Kim, David B. Reuben, Gail A. Greendale, Alison A. Moore); and Geriatric Research Education and Clinical Center, VA

A New Adenovirus Based Vaccine Vector Expressing an Eimeria tenella Derived TLR Agonist Improves Cellular Immune Responses to an Antigenic Target

Background Adenoviral based vectors remain promising vaccine platforms for use against numerous pathogens, including HIV. Recent vaccine trials utilizing Adenovirus based vaccines expressing HIV antigens confirmed induction of cellular immune responses, but these responses failed to prevent HIV infections in vaccinees. This illustrates the need to develop vaccine formulations...