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Systematic review of outcome measures in pediatric eosinophilic esophagitis treatment trials

Background Heterogeneity has been noted in the selection and reporting of disease-specific, pediatric outcomes in randomized controlled trials (RCTs). The consequence is invalid results or difficulty comparing results across trials. The primary objective of this systematic review was to assess primary outcome and outcome measure selection and reporting, in pediatric eosinophilic ...

How to select outcome measurement instruments for outcomes included in a “Core Outcome Set” – a practical guideline

Background In cooperation with the Core Outcome Measures in Effectiveness Trials (COMET) initiative, the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) initiative aimed to develop a guideline on how to select outcome measurement instruments for outcomes (i.e., constructs or domains) included in a “Core Outcome Set” (COS). A COS is an agreed ...

Melatonin in Youth: N-of-1 trials in a stimulant-treated ADHD Population (MYNAP): study protocol for a randomized controlled trial

Senior 2 7 Geoffrey Mitchell 7 Christopher H. Schmid 6 Helen Heussler 5 Manisha Witmans 4 Sunita Vohra 1 0 1702 College Plaza , 8512-112 Street NW, Edmonton, Alberta T6G 2C8 , Canada 1 Complementary and

Development and Preliminary Face and Content Validation of the “Which Health Approaches and Treatments Are You Using?” (WHAT) Questionnaires Assessing Complementary and Alternative Medicine Use in Pediatric Rheumatology

funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Dr. Sunita Vohra received salary support from Alberta Innovates-Health Solutions as ... , the Arthritis Society and the Canadian Institutes of Health Research. Dr. Sunita Vohra received salary support from Alberta Innovates-Health Solutions as a Health Scholar. We would like to thank David

Rhodiola Rosea for Mental and Physical Fatigue in Nursing Students: A Randomized Controlled Trial

Background Fatigue is one of many unintended consequences of shift work in the nursing profession. Natural health products (NHPs) for fatigue are becoming an increasingly popular topic of clinical study; one such NHP is Rhodiola rosea. A well-designed, rigorously conducted randomized controlled trial is required before therapeutic claims for this product can be made. Objective To ...

Systematic review of outcome measures in trials of pediatric anaphylaxis treatment

Background Considerable heterogeneity has been observed in the selection and reporting of disease-specific pediatric outcome measures in randomized controlled trials (RCTs). This makes interpretation of results and comparison across trials challenging. Outcome measures in pediatric anaphylaxis trials have never previously been systematically assessed. This systematic review (SR) ...

The Quality of Reports on Cervical Arterial Dissection following Cervical Spinal Manipulation

Research Chairs program. Sunita Vohra receives salary support from Alberta Innovates-Health Solutions. Training support for Shari Wynd was provided by the Alberta Canadian Institutes of Health Research (CIHR

CAM Use in Pediatric Neurology: An Exploration of Concurrent Use with Conventional Medicine

of commonly used therapies. - Funding: This project was supported by a grant from the SickKids Foundation. Sunita Vohra receives salary support from Alberta Innovates-Health Solutions (formerly

Core Outcome Measures in Effectiveness Trials (COMET) initiative: protocol for an international Delphi study to achieve consensus on how to select outcome measurement instruments for outcomes included in a ‘core outcome set’

Background The Core Outcome Measures in Effectiveness Trials (COMET) initiative aims to facilitate the development and application of ‘core outcome sets’ (COS). A COS is an agreed minimum set of outcomes that should be measured and reported in all clinical trials of a specific disease or trial population. The overall aim of the Core Outcome Measurement Instrument Selection (COMIS) ...

Pediatric integrative medicine: pediatrics' newest subspecialty?

Background Integrative medicine is defined as relationship-centered care that focuses on the whole person, is informed by evidence, and makes use of all appropriate therapeutic approaches, healthcare professionals and disciplines to achieve optimal health and healing, including evidence-based complementary and alternative medicine. Pediatric integrative medicine (PIM) develops and ...

Measurement Properties of Questionnaires Assessing Complementary and Alternative Medicine Use in Pediatrics: A Systematic Review

Boon Ciara n M. Duffy Tamara Rader Sunita Vohra Peter Tugwell Robert S. Phillips, University of York, United Kingdom Objective: Complementary and alternative medicine (CAM) is commonly used by children ... Health and Long-term Care Career Scientist Award. Dr. Ciaran M Duffy holds an Endowed Chair, Department of Paediatrics, University of Ottawa. Dr. Sunita Vohra receives salary support as an Alberta

Study of Natural Health Product Adverse Reactions (SONAR): Active Surveillance of Adverse Events Following Concurrent Natural Health Product and Prescription Drug Use in Community Pharmacies

Background Many consumers use natural health products (NHPs) concurrently with prescription medications. As NHP-related harms are under-reported through passive surveillance, the safety of concurrent NHP-drug use remains unknown. To conduct active surveillance in participating community pharmacies to identify adverse events related to concurrent NHP-prescription drug use. ...

Integrating complementary and alternative medicine into academic medical centers: Experience and perceptions of nine leading centers in North America

Background Patients across North America are using complementary and alternative medicine (CAM) with increasing frequency as part of their management of many different health conditions. The objective of this study was to develop a guide for academic health sciences centers that may wish to consider starting an integrative medicine program. Methods We queried North American leaders ...

Vitamin D Receptor Polymorphisms and the Risk of Acute Lower Respiratory Tract Infection in Early Childhood

To investigate associations of 2 vitamin D receptor (VDR) gene polymorphisms and acute lower respiratory tract infection (ALRI),wecompared 56 young children hospitalized with ALRI and 64 children without a history of ALRI. The FokI ff genotype was associated with an adjusted relative odds of ALRI that was ∼7 times that of FokI FF. A weaker association with the TaqI polymorphism was ...