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18 papers found.
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Diagnostic utility of a line probe assay for multidrug resistant-TB in smear-negative pulmonary tuberculosis

Contributions Conceptualization: Binit Kumar Singh, Surendra K. Sharma. Data curation: Binit Kumar Singh, Surendra K. Sharma, Rohini Sharma, Vishnubhatla Sreenivas, Mikashmi Kohli. Formal analysis: Binit Kumar ... Singh, Surendra K. Sharma, Rohini Sharma, Vishnubhatla Sreenivas, Mikashmi Kohli, Dinkar Bhasin. Funding acquisition: Surendra K. Sharma. Investigation: Surendra K. Sharma. Methodology: Binit Kumar

Comparison of TST and IGRA in Diagnosis of Latent Tuberculosis Infection in a High TB-Burden Setting

Welfare, Government of India and Department of Biotechnology (DBT), (No.BT/ PR7730/Med/14/1080/2006) Ministry of Science and Technology, Government of India. Surendra K. Sharma was supported by J.C. Bose

Evaluating the Diagnostic Accuracy of Xpert MTB/RIF Assay in Pulmonary Tuberculosis

Pulmonary tuberculosis still remains a major communicable disease worldwide. In 2013, 9 million people developed TB and 1.5 million people died from the disease. India constitutes 24% of the total TB burden. Early detection of TB cases is the key to successful treatment and reduction of disease transmission. Xpert MTB/RIF, an automated cartridge-based molecular technique detects...

Procalcitonin as a prognostic marker for sepsis: a prospective observational study

Background Procalcitonin is useful for the diagnosis of sepsis but its prognostic value regarding mortality is unclear. This prospective observational study was designed to study the prognostic value of procalcitonin in prediction of 28 day mortality in patients of sepsis. Fifty-four consecutive patients of sepsis, severe sepsis and septic shock defined using the 2001 Consensus...

Diffuse small bowel thickening in aids patient - a case report

BMC Infectious Diseases Diffuse small bowel thickening in Aids patient - a case report Rohit Singla 0 Samriti Hari 1 Surendra K Sharma 0 0 Department of Medicine, All India Institute of Medical

Spontaneous Splenic Rupture in Dengue Hemorrhagic Fever

Authors' addresses: Surendra K. Sharma and Tamilarasu Kadhira- van, Department of Medicine, All India Institute of Medical Sciences , Ansari Nagar, New Delhi 110608 , India , Telephone: 91-11-26594415, F a

Genetic polymorphisms in TNF genes and tuberculosis in North Indians

Background Pulmonary tuberculosis, the most common clinical form of mycobacterial diseases, is a granulomatous disease of the lungs caused by Mycobaterium tuberculosis. A number of genes have been identified in studies of diverse origins to be important in tuberculosis. Of these, both tumor necrosis factor α (TNF-α) and lymphotoxin α (LT-α) play important immunoregulatory roles...

Nevirapine versus efavirenz-based antiretroviral therapy regimens in antiretroviral-naive patients with HIV and tuberculosis infections in India: a pilot study

Background Administration of rifampicin along with nevirapine reduces the plasma concentration of nevirapine in human immunodeficiency virus positive individuals with concomitant tuberculosis (HIV-TB patients). Nevirapine is a much cheaper drug than its alternative efavirenz, and might be beneficial in resource constrained settings. Methods A randomised open label trial was...

Comparative Evaluation of GenoType MTBDRplus Line Probe Assay with Solid Culture Method in Early Diagnosis of Multidrug Resistant Tuberculosis (MDR-TB) at a Tertiary Care Centre in India

Background The objectives of the study were to compare the performance of line probe assay (GenoType MTBDRplus) with solid culture method for an early diagnosis of multidrug resistant tuberculosis (MDR-TB), and to study the mutation patterns associated with rpoB, katG and inhA genes at a tertiary care centre in north India. Methods In this cross-sectional study, 269 previously...

Early versus delayed initiation of antiretroviral therapy for Indian HIV-Infected individuals with tuberculosis on antituberculosis treatment

BackgroundFor antiretroviral therapy (ART) naive human immunodeficiency virus (HIV) infected adults suffering from tuberculosis (TB), there is uncertainty about the optimal time to initiate highly active antiretroviral therapy (HAART) after starting antituberculosis treatment (ATT), in order to minimize mortality, HIV disease progression, and adverse events.MethodsIn a randomized...

Reply to Chang and Leung

result from com Reprints or correspondence: Dr Surendra K. Sharma , Dept of Medicine, All India Institute of Medical Sciences, New Dehli , 110029 India ( .in). Clinical Infectious Diseases 2010 ; 51 ( 3

Safety of 3 Different Reintroduction Regimens of Antituberculosis Drugs after Development of Antituberculosis Treatment–Induced Hepatotoxicity

Background. Drug-induced hepatotoxicity (DIH) is the most common adverse drug reaction leading to interruption of antituberculosis treatment. Worldwide, different reintroduction regimens have been advocated, but no consensus guidelines are available. Reintroduction of antituberculosis drugs in patients with DIH has never been studied systematically. We aimed to compare the safety...

Lemierre's syndrome due to community-acquired meticillin-resistant Staphylococcus aureus infection and presenting with orbital cellulitis: a case report

Introduction Lemierre's syndrome is septic thrombophlebitis of the internal jugular vein leading to metastatic septic complications following an oropharyngeal infection. It is usually caused by the anaerobe, Fusobacterium necrophorum. Of late, meticillin-resistant Staphylococcus aureus is increasingly being recognised as a cause of community-acquired skin and soft tissue...

Topical Ocular Delivery of NSAIDs

In ocular tissue, arachidonic acid is metabolized by cyclooxygenase to prostaglandins which are the most important lipid derived mediators of inflammation. Presently nonsteroidal anti-inflammatory drugs (NSAIDs) which are cyclooxygenase (COX) inhibitors are being used for the treatment of inflammatory disorders. NSAIDs used in ophthalmology, topically, are salicylic-, indole...

Poor follow-up rates at a self-pay northern Indian tertiary AIDS clinic

Basu 1 Surendra K Sharma 1 0 Department of Medicine, Yale University School of Medicine , New Haven, CT, 06510 , USA 1 AIDS Program, Department of Internal Medicine, All India Institute of Medical

Human Leukocyte Antigen Class I Supertypes Influence Susceptibility and Severity of Tuberculosis

Although both differential susceptibility to Mycobacterium tuberculosis infection and disease pathogenesis depend on a multitude of factors, elucidation of specific host genetic markers, particularly those in the human major histocompatibilty complex, is important. The present study is an attempt to delineate human leukocyte antigen (HLA) class I association in tuberculosis (TB...

Clinical presentation and predictors of outcome in patients with severe acute exacerbation of chronic obstructive pulmonary disease requiring admission to intensive care unit

Background Severe acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) is a common reason for emergency room (ER) visit about which little has been documented from India. Methods Prospective study of the clinical presentation and predictors of outcome in 116 patients presenting with severe AE-COPD requiring admission to the medical intensive care unit between...