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HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation

Diseases Network (Quebec) for administrative coordination for obtaining blood specimens from HIV-infected patients. Conceptualization: Ali Ahmad. Data curation: Ossama Allam, Suzanne Samarani, Mohammad-Ali ... Jenabian. Formal analysis: Ossama Allam, Suzanne Samarani, Devendra Amre, Ali Ahmad. Funding acquisition: Ali Ahmad. Investigation: Ossama Allam. Methodology: Vikram Mehraj, Mohammad-Ali Jenabian. Project

HIV-1 causes an imbalance in the production of interleukin-18 and its natural antagonist in HIV-infected individuals: Implications for enhanced viral replication

Background. Concentrations of interleukin (IL)-18 increase in the circulation of human immunodeficiency virus (HIV)-infected persons. However, nothing is known concerning the regulation of IL-18-binding protein (IL-18BP), which neutralizes IL-18 in vivo. This issue is addressed in the present study. Methods. Serum samples obtained from healthy subjects and HIV-infected patients...

Le natural killer, fer de lance des futures immunothérapies anti-tumorales ?

Au cours de la dernière décennie, de considérables progrès ont été réalisés dans la compréhension des mécanismes d’action des cellules NK, et spécialement dans les processus de reconnaissance et de lyse des cellules cibles. Ces percées pourraient conduire à de nouvelles applications cliniques recrutant les cellules NK comme outils thérapeutiques lors de greffes de moelle osseuse...

Lymphocytic Microparticles Modulate Angiogenic Properties of Macrophages in Laser-induced Choroidal Neovascularization

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