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The role of IL-10 in Mycobacterium avium subsp. paratuberculosis infection

Mycobacterium avium subsp. paratuberculosis (MAP) is an intracellular pathogen and is the causative agent of Johne’s disease of domestic and wild ruminants. Johne’s disease is characterized by chronic granulomatous enteritis leading to substantial economic losses to the livestock sector across the world. MAP persistently survives in phagocytic cells, most commonly in macrophages by ...

Complete genome sequence of Streptococcus agalactiae strain GBS85147 serotype of type Ia isolated from human oropharynx

Streptococcus agalactiae, also referred to as Group B Streptococcus, is a frequent resident of the rectovaginal tract in humans, and a major cause of neonatal infection. The pathogen can also infect adults with underlying disease, particularly the elderly and immunocompromised ones. In addition, S. agalactiae is a known fish pathogen, which compromises food safety and represents a ...

Using a mobile health application to support self-management in chronic obstructive pulmonary disease: a six-month cohort study

Background Self-management strategies have the potential to support patients with chronic obstructive pulmonary disease (COPD). Telehealth interventions may have a role in delivering this support along with the opportunity to monitor symptoms and physiological variables. This paper reports findings from a six-month, clinical, cohort study of COPD patients’ use of a mobile ...

Effects of silencing key genes in the capsanthin biosynthetic pathway on fruit color of detached pepper fruits

Background There are many varieties of carotenoids in pepper fruits. Capsanthin is a red carotenoid that gives mature pepper fruits their red color. The red color in pepper fruits is regulated mainly by the genes capsanthin/capsorubin synthase(Ccs), phytoene synthase(Psy), lycopene-?-cyclase(Lcyb) and ?-carotene hydroxylase(Crtz). There has been very limited research work related ...

Elective ICP monitoring: how long is long enough?

Neekhil Patel Syed Shah Andrew Stevens Huan Wee Chan Jinendra Ekanayake Ahmed Toma Lewis Thorne Laurence Watkins Authors' details 1The National Hospital for Neurology and Neurosurgery, UK. 2Imperial

Self-medication with antibiotics among non-medical university students of Karachi: a cross-sectional study

Background The prevalence of self -medication with antibiotics is quite high in developing countries as opposed to developed countries. Antibiotics are often taken erroneously for certain ailments, without having the appropriate knowledge of their use. This carries potential risks for the individual as well as the community, in form of several side effects such as antibiotic ...

Three-dimensional numerical simulation of a vertical axis tidal turbine using the two-way fluid structure interaction approach

The objective of this study was to develop, as well as validate the strongly coupled method (two-way fluid structural interaction (FSI)) used to simulate the transient FSI response of the vertical axis tidal turbine (VATT) rotor, subjected to spatially varying inflow. Moreover, this study examined strategies on improving techniques used for mesh deformation that account for large ...

Patients' perspectives on self-testing of oral anticoagulation therapy: Content analysis of patients' internet blogs

Background Patients on oral anticoagulant therapy (OAT) require regular testing of the prothrombin time (PT) and the international normalised ratio (INR) to monitor their blood coagulation level to avoid complications of either over or under coagulation. PT/INR can be tested by a healthcare professional or by the patient. The latter mode of the testing is known as patient ...

Compulsive buying and credit card misuse among credit card holders: The roles of self-esteem, materialism, impulsive buying and budget constraint

Purpose: This study aims to examine the factors that influence credit card misuse among working adults in Klang Valley, Malaysia. The relationship among self-esteem, materialism, impulsive buying, budget constraint, compulsive buying and credit card misuse are explored in this study. Design/methodology/approach: A total of 186 questionnaires was collected via convenience sampling ...

Negative and positive impact of internet addiction on young adults: Empericial study in Malaysia

IC 1697-9818 Syed Shah Alam Nik Mohd. Hazrul Nik Hashim 0 Maisarah Ahmad Che Aniza Che Wel Sallehuddin Mohd Nor Nor Asiah Omar 0 The National University of Malaysia (Malaysia) Purpose: The

Job Stress with Supervisor’s Social Support as a Determinant of Work Intrusion on Family Conflict

Purpose: The primary objective of this study is to examine the influence of supervisor’s social support in the correlation between job stress and work intrusion on family conflict.Design/methodology/approach: A survey method was employed to gather survey questionnaires from academic staff in a Malaysian government university in Borneo. Findings: The outcomes of SmartPLS path model ...

Relationship between islamic human resources management (IHRM) practices and trust: An empirical study

Purpose: The purpose of this study is to explore and examines the theoretical frameworks of Islamic human resource management practices and trust in organization. Additionally, to investigate the extent to which Islamic HRM practices inspire and revival employees trust in organization.Design/methodology/approach: This study comprised sample of 236 Islamic Bank employees in ...

Model-guided therapy for hepatocellular carcinoma: a role for information technology in predictive, preventive and personalized medicine

Predictive, preventive and personalized medicine (PPPM) may have the potential to eventually improve the nature of health care delivery. However, the tools required for a practical and comprehensive form of PPPM that is capable of handling the vast amounts of medical information that is currently available are currently lacking. This article reviews a rationale and method for ...

Exoproteome and Secretome Derived Broad Spectrum Novel Drug and Vaccine Candidates in Vibrio cholerae Targeted by Piper betel Derived Compounds

Sudha Chandra Neha Jain Sandeep Tiwari Nidia Leon-Sicairos Adrian Canizalez-Roman Anderson Rodrigues dos Santos Syed Shah Hassan Sntia Almeida Rommel Thiago Juca Ramos Vinicius Augusto Carvalho de Abreu

Subjects With Early-Onset Type 2 Diabetes Show Defective Activation of the Skeletal Muscle PGC-1α/Mitofusin-2 Regulatory Pathway in Response to Physical Activity

MARA ISABEL HERN ANDEZ-ALVAREZ MSC HOOD THABIT NICOLE BURNS MSC SYED SHAH IMAD BREMA MENSUD HATUNIC OBJECTIVE - Type 2 diabetes is associated with insulin resistance and skeletal muscle

Complete genome sequence of Streptococcus agalactiae strain SA20-06, a fish pathogen associated to meningoencephalitis outbreaks

Streptococcus agalactiae (Lancefield group B; GBS) is the causative agent of meningoencephalitis in fish, mastitis in cows, and neonatal sepsis in humans. Meningoencephalitis is a major health problem for tilapia farming and is responsible for high economic losses worldwide. Despite its importance, the genomic characteristics and the main molecular mechanisms involved in virulence ...