Traditional Chinese Medicine Hospital , Zhangjiagang , China 3 Clinical Laboratory, Kunshan Hospital of Traditional Chinese Medicine , Kunshan, China Contributions: (I) Conception and design: T Yang; (II
The primary objective of the study was to evaluate the safety and tolerability of single oral doses of sutezolid tablets administered under fasting conditions in healthy adult subjects. The secondary objective was to determine the pharmacokinetics (PK) ...
Environmental exposures can regulate intermediate molecular phenotypes, such as gene expression, by different mechanisms and thereby lead to various health outcomes. It is of significant scientific interest to unravel the role of potentially high-dimensional ...
Piwi-interacting RNAs (piRNAs) are the small non-coding RNAs (ncRNAs) that silence genomic transposable elements. And researchers found out that piRNA also regulates various endogenous transcripts. However, there is no systematic understanding of the ...
) Administrative support: H Sun; (III) Provision of study materials or patients: H Sun; (IV) Collection and assembly of data: F Ju, B Li, X Luo, H Wu, T Yang; (V) Data analysis and interpretation: F Ju; (VI
The rank product statistic has been widely used to detect differentially expressed genes in replicated microarrays and a one-class setting. The objective of this article is to apply a rank product statistic to approximate the P-value of differential expression ...
With the rapid growth of economy in coastal megacities, the construction of supertall buildings with deep pile foundations adjacent to tunnels in soft soil is inevitable. The additional subsidence of tunnel and long-term subsidence of soft soil was appeared caused by the supertall building load transferred through pile foundation. In this paper, a typical case in Shanghai where...
Biliary complications are the leading causes of morbidity and mortality after liver transplant (LT). However, national data on endoscopic retrograde cholangiopancreatography (ERCP) usage and outcomes in LT patients are lacking. Our study aims to identify ...
Large-scale land subsidence often occurs after large-scale land formation caused by dredger fill, which affects the sustainable development of the region. In order to prevent and control land subsidence in the area with dredger fill, the characteristics of land subsidence and its main influencing factors need to be studied. A typical region was examined using geological survey...
Since 1960s, Artificial Recharge has been adopted to control the geological disaster of land subsidence in Shanghai. The water source to recharge to the confined aquifer meet the Standard for Drinking Water Quality which comes from the Huangpu River or Yangtze River. Thinking the difference between the primary environment of deep confined aquifer and the surface water, the...
Shanghai has a long history of exploitation and utilization of groundwater in order to meet the needs of industrial production and residential water. As a result, serious land subsidence disasters were induced. Land subsidence poses a huge security threat to the low-altitude coastal city of Shanghai. The development of land subsidence in Shanghai is closely related to the...
The genomics data analysis has been widely used to study disease genes and drug targets. However, the existence of missing values in genomics datasets poses a significant problem, which severely hinders the use of genomics data. Current imputation methods ...
Long noncoding RNAs (lncRNAs) have emerged as the key regulators in the pathogenesis of human disorders. This study aimed to investigate the role of lncRNA-IPW in the progression of choroidal neovascularization (CNV) and the underlying molecular mechanism. ...
Glioma characterized by high morbidity and mortality, is one of the most common brain tumors. The application of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) in differentiating glioma grading and IDH1 mutation status were poorly ...
Background: An electrocardiogram (ECG) is a simple and cheap non-invasive tool that shows various abnormalities and has prognostic value for patients with light-chain amyloidosis (AL). The present study aimed to explore the association between ECG characteristics ...
Purpose: This study aimed to evaluate the effect of continuous clustered care on the physical growth of preterm infants and on the satisfaction with the nursing care. Methods: 120 preterm infants who were admitted to our hospital from Jan 2018 to Dec ...
Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation and destruction of the lung air-blood barrier, leading to irreversible and substantial respiratory function damage. Patients with coronavirus disease 2019 (COVID-19) ...