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Search: authors:"Tadahisa Sugiura"

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Tissue-engineered cardiac patch seeded with human induced pluripotent stem cell derived cardiomyocytes promoted the regeneration of host cardiomyocytes in a rat model

Background Thousands of babies are born with congenital heart defects that require surgical repair involving a prosthetic implant. Lack of growth in prosthetic grafts is especially detrimental in pediatric surgery. Cell seeded biodegradable tissue engineered grafts are a novel solution to this problem. The purpose of the present study is to evaluate the feasibility of seeding human ...

Tissue-Engineered Small Diameter Arterial Vascular Grafts from Cell-Free Nanofiber PCL/Chitosan Scaffolds in a Sheep Model

Tissue engineered vascular grafts (TEVGs) have the potential to overcome the issues faced by existing small diameter prosthetic grafts by providing a biodegradable scaffold where the patient’s own cells can engraft and form functional neotissue. However, applying classical approaches to create arterial TEVGs using slow degrading materials with supraphysiological mechanical ...

Successful explantation of ventricular assist device for systemic ventricular assistance in a patient with congenitally corrected transposition of the great arteries

We report a case of a 13-year-old boy with congenitally corrected transposition of the great arteries after conventional repair who underwent an implantation of ventricular assist device (VAD) due to right (systemic) ventricular failure after tricuspid valve replacement. The anatomical right ventricle (systemic ventricle) was completely unloaded and the function improved over time ...