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Comorbidities according to airflow limitation severity: data from comprehensive health examination in Japan

Objectives The present study aimed to investigate the relationship between airflow limitation (AL) severity and comorbidities in comprehensive health examination. Methods This cross-sectional study included 6661 men and 6044 women aged 40–89 who underwent a lung function test during medical checkups. AL was defined as forced expiratory volume in 1 s/forced vital capacity of < 0.7. ...

In commemoration of the 20th anniversary

reading and submitting articles. Gratefully yours, and with many thanks for your contributions to EHPM. Editor-in-Chief Takemi Otsuki Deputy Editor-in-Chief Takahiko Katoh

Greetings from the New Editor-in-Chief

Takemi Otsuki 0 Takahiko Katoh 0 0 T. Otsuki (&) T. Katoh Department of Hygiene, Kawasaki Medical School , Kurashiki, Japan Environmental Health and Preventive Medicine (EHPM), an official ... hope all individuals related to these scientific fields focus attention on EHPM and collaborate to develop our journal. Editor-in-Chief: Takemi Otsuki, M.D., Ph.D. Associate Editor-in-Chief: Takahiko

A Large Cohort Study Concerning Age-Dependent Impacts of Anthropometric Variables on Spirometric Parameters in Nonsmoking Healthy Adults

Backgrounds Although height (H) has been considered the principal anthropometric variable governing lung function, the age-dependent differences in its influences on determining spirometric parameters (SPs) have not been conclusively investigated. Moreover, there has been no study centered on age-dependent effects of other anthropometric variables, including body weight (BW) and ...

Evaluation of Genetic Polymorphisms in Patients with Multiple Chemical Sensitivity

ObjectiveMultiple chemical sensitivity (MCS) is a chronic medical condition characterized by symptoms that the affect an individual’s response to low-level chemical exposure. In this study, we identified a chemical sensitive population (CSP) and investigated the effect of genetic polymorphisms on their risk of chemical sensitivity. MethodsA quick environment exposure sensitivity ...

Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes

Background An increased leukocyte count is an independent risk factor for cardiovascular events, but the association between leukocyte subtype counts and carotid atherosclerosis in patients with diabetes has not been determined. We therefore investigated the correlation between leukocyte subtype counts and intima-media thickness of the common carotid artery (CCA-IMT) in subjects ...

Replication of Prostate Cancer Risk Loci in a Japanese Case–Control Association Study

Background Two prostate cancer genome-wide scans in populations of European ancestry identified several genetic variants that are strongly associated with prostate cancer risk. The effect of these risk variants and their cumulative effect in other populations are unknown.

Interaction between cytochrome P450 gene polymorphisms and serum organochlorine TEQ levels in the risk of endometriosis

Exposure to dioxins and polychlorinated biphenyls (PCBs) has been suggested as a possible etiologic factor for endometriosis, but the association remains highly controversial. To assess whether cytochrome P450 (CYP) gene polymorphisms modulate the effect of dioxins and/or PCBs in endometriosis risk, we conducted a case–control study among infertile Japanese women. A total of 138 ...

Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma

Genes coding for the glutatione S-transferase M1 (GSTM1) and Theta 1 (GSTT1) proteins are polymorphic in humans and these genes are absent, or homozygous null, in 10–60% of different ethnic populations. These enzymes catalyze the conjugation of glutathione to numerous carcinogenic chemicals and previous epidemiologic studies have associated the null genotypes of these GST genes ...

Pooled Analysis and Meta-analysis of Glutathione S-Transferase M1 and Bladder Cancer: A HuGE Review

Smoking is a known risk factor for bladder cancer. The product of the GSTM1 gene, glutathione S-transferase M1 (GSTM1), is involved in the detoxification of polycyclic aromatic hydrocarbons found in tobacco smoke; a homozygous deletion of this gene in approximately 50% of Caucasians and Asians results in a lack of GSTM1 enzyme activity. Most studies examining the relation between ...