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15 papers found.
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The Relationship between Multiple Myeloma with Renal Failure and Metastatic Calcification

While cases of multiple myeloma (MM) with metastatic calcification have been reported, the mechanisms for this calcification have yet to be explained. We observed a case of MM in a patient with end-stage renal failure who developed vascular and pulmonary calcification. A 51-year-old male was diagnosed with Bence-Jones type MM and required maintenance hemodialysis. He was treated...

Macroscopically Anisotropic Structures Produced by Light-induced Solvothermal Assembly of Porphyrin Dimers

Porphyrin-based molecules play an important role in natural biological systems such as photosynthetic antennae and haemoglobin. Recent organic chemistry provides artificial porphyrin-based molecules having unique electronic and optical properties, which leads to wide applications in material science. Here, we successfully produced many macroscopically anisotropic structures...

Motion-tracking skill assist and power assist for sinusoidal motions with a semi-active assist mechanism using energy control

Hidekazu Kajiwara 0 2 0 Takashi Kusaka, Takayuki Tanaka and Hidekazu Kajiwara contributed equally for this paper 1 The Graduate School of Information Science and Technology, Hokkaido University , N14, W9

Effective prevention of sorafenib-induced hand–foot syndrome by dried-bonito broth

Hiroteru Kamimura,1 Takeshi Suda,2 Hiroshi Baba,3 Takayuki Tanaka,4 Yoshizu Nozawa,5 Naoto Koyama,6 Masaaki Takamura,1 Hirokazu Kawai,1 Satoshi Yamagiwa,1 Yutaka Aoyagi,1 Shuji Terai1 1Division of

How well are biodiversity drivers reflected in protected areas? A representativeness assessment of the geohistorical gradients that shaped endemic flora in Japan

Protected areas function as a lifeboat that can preserve the origins and maintenance of biodiversity. We assessed the representativeness of biodiversity in existing protected areas in Japan using a distribution dataset and phylogenetic tree for 5565 Japanese vascular plant species. We first examined the overlap of species distribution with the existing protected areas and...

Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma

Background Pancreatic ductal adenocarcinoma (PDAC) is known as one of the most malignant potential diseases with poor neovascularization. By comparing PDAC to hepatocellular carcinoma (HCC), which is well vascularized, we investigated the mechanisms and tumor biological significance of the poor neovascularization in PDAC. Methods Surgical specimens from primary PDAC and HCC...

Interactive network analysis of the plasma amino acids profile in a mouse model of hyperglycemia

Amino acids are a group of metabolites that are important substrates for protein synthesis, are important as signaling molecules and play central roles as highly connected metabolic hubs, and therefore, there are many reports that describe disease-specific abnormalities in plasma amino acids profile. However, the causes of progression from a healthy control to a manifestation of...

Mathematical Identification of Critical Reactions in the Interlocked Feedback Model

Dynamic simulations are necessary for understanding the mechanism of how biochemical networks generate robust properties to environmental stresses or genetic changes. Sensitivity analysis allows the linking of robustness to network structure. However, it yields only local properties regarding a particular choice of plausible parameter values, because it is hard to know the exact...

Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells

, Yuriko Kitajima, Takayuki Tanaka, Shinji Goto, Yusuke Ono & Tao-Sheng LiDepartment of Surgery and Clinical Sciences, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi ... • Google ScholarSearch for Hanako Doi in:Nature Research journals • PubMed • Google ScholarSearch for Yuriko Kitajima in:Nature Research journals • PubMed • Google ScholarSearch for Takayuki Tanaka in:Nature

Progression rate of total, and upper and lower visual field defects in open-angle glaucoma patients

Progression rate of total, and upper and lower visual field defects in open-angle glaucoma patients Takeo Fukuchi, Takaiko Yoshino, Hideko Sawada, Masaaki Seki, Tetsuya Togano, Takayuki Tanaka, Jun ... ep on PowerdbyTCPDF( Takeo Fukuchi; Takaiko Yoshino hideko; sawada; Masaaki seki; Tetsuya Togano; Takayuki Tanaka; Jun Ueda haruki Abe Division of Ophthalmology and Visual s cience, g

Robust and Highly-Efficient Differentiation of Functional Monocytic Cells from Human Pluripotent Stem Cells under Serum- and Feeder Cell-Free Conditions

Monocytic lineage cells (monocytes, macrophages and dendritic cells) play important roles in immune responses and are involved in various pathological conditions. The development of monocytic cells from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) is of particular interest because it provides an unlimited cell source for clinical application and...

Incidence, severity and factors related to drug-induced keratoepitheliopathy with glaucoma medications

, Takayuki Tanaka, Akiko Yamada, Haruki AbeDivision of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, JapanPurpose: To evaluate the incidence

Liver metastasis in gastric cancer with particular reference to lymphatic advancement

Background. We have previously reported that, in models of mesenteric lymph vessel obstruction in rats, we observed lymphaticovenous communication. This suggested that cancer cells metastasized to the liver by a lymphatic route. In the present study, we investigated the relationship between liver metastasis and lymphatic involvement in gastric carcinoma by examining resected...

Involvement of Brain-Derived Neurotrophic Factor in Early Retinal Neuropathy of Streptozotocin-Induced Diabetes in Rats: Therapeutic Potential of Brain-Derived Neurotrophic Factor for Dopaminergic Amacrine Cells

Although neurotrophins have been assessed as candidate therapeutic agents for neural complications of diabetes, their involvement in diabetic retinopathy has not been fully characterized. We found that the protein and mRNA levels of brain-derived neurotrophic factor (BDNF) in streptozotocin-induced diabetic rat retinas were reduced to 49% (P < 0.005) and 74% (P < 0.05...