of Public Health, Baltimore, MD, USA Tamaki Kobayashi Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Tamaki Kobayashi & Matthew M. Ippolito Division ... search for this author in PubMed Google Scholar Tamaki Kobayashi View author publications You can also search for this author in PubMed Google Scholar Matthew M. Ippolito View author publications
the Johns Hopkins Malaria Research Institute. Author information AffiliationsJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USAMarisa Hast, Tamaki Kobayashi, Timothy Shields, Justin ... Scholar Search for Jay Sikalima in:PubMed • Google Scholar Search for Tamaki Kobayashi in:PubMed • Google Scholar Search for Timothy Shields in:PubMed • Google Scholar Search for Modest Mulenga in:PubMed
Momoe Endo Mamiko Sato Hiroaki Gotoh Tomomi Iwai Ryosuke Tateishi Hiromi Hikita Tamaki Kobayashi Kazuhiko Koike YutakaYatomi Hitoshi Ikeda OPEN Published: xx xx xxxx Chronic hepatitis C virus (HCV
Medicine , La Jolla, California 2 Authors' addresses: Tamaki Kobayashi, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD Diagnosis is “the act of identifying a
, Baltimore , Maryland; Tropical Disease Research Centre , Ndola , Zambia 2 Mike Chaponda , Timothy Shields, James Lupiya, Tamaki Kobayashi, Modest Mulenga, William J. Moss , and Frank C. Curriero for the ... Southern Africa International Centers of Excellence for Malaria Research 3 Authors' addresses: Jessie Pinchoff , Timothy Shields, Tamaki Kobayashi, William J. Moss, and Frank C. Curriero , Department of
Background As malaria transmission declines in many regions of sub-Saharan Africa, interventions to identify the asymptomatic reservoir are being deployed with the goals of improving surveillance and interrupting transmission. Reactive case detection strategies, in which individuals with clinical malaria are followed up at their home and household residents and neighbours are...
Substantial reductions in the burden of malaria have been documented in parts of sub-Saharan Africa, with elimination strategies and goals being formulated in some regions. Within this context, understanding the epidemiology of low-level malaria transmission is crucial to achieving and sustaining elimination. A 24 single-nucleotide-polymorphism Plasmodium falciparum molecular...
Background Rapid diagnostic tests (RDTs) detecting histidine-rich protein 2 (PfHRP2) antigen are used to identify individuals with Plasmodium falciparum infection even in low transmission settings seeking to achieve elimination. However, these RDTs lack sensitivity to detect low-density infections, produce false negatives for P. falciparum strains lacking pfhrp2 gene and do not...
As malaria transmission declines in many regions of sub-Saharan Africa, interventions to identify the asymptomatic reservoir are being deployed with the goals of improving surveillance and interrupting transmission. Reactive case detection strategies, in which individuals with clinical malaria are followed up at their home and household residents and neighbours are screened and...
Background Autotaxin (ATX) is a secreted enzyme that converts lysophosphatidylcholine to lysophosphatidic acid, a potent bioactive lipid mediator, through its lysophospholipase D activity. Although five alternative splicing isoforms of ATX have been identified as ATXα, ATXβ, ATXγ, ATXδ, and ATXε and the expression patterns of each isoform differ among several tissues, the...
The prevalence of malaria has reduced significantly in some areas over the past decade. These reductions have made local elimination possible and the research agenda has shifted to this new priority. However, there are critical issues that arise when studying malaria in low transmission settings, particularly identifying asymptomatic infections, accurate detection of individuals...
The prevalence of malaria has reduced significantly in some areas over the past decade. These reductions have made local elimination possible and the research agenda has shifted to this new priority. However, there are critical issues that arise when studying malaria in low transmission settings, particularly identifying asymptomatic infections, accurate detection of individuals...
Background Critical to sustaining progress in malaria control is comprehensive surveillance to identify outbreaks and prevent resurgence. Serologic responses to Plasmodium falciparum antigens can serve as a marker of recent transmission and serosurveillance may be feasible on a large scale. Methods Satellite images were used to construct a sampling frame for the random selection...
Background The scale-up of malaria control interventions has resulted in substantial declines in transmission in some but not all regions of sub-Saharan Africa. Understanding factors associated with persistent malaria transmission despite control efforts may guide targeted interventions to high-risk areas and populations. Methods Household malaria surveys were conducted in...
Background Case detection and treatment are critical to malaria control and elimination as infected individuals who do not seek medical care can serve as persistent reservoirs for transmission. Methods Household malaria surveys were conducted in two study areas within Southern Province, Zambia in 2007 and 2008. Cross-sectional surveys were conducted approximately five times...
Background In formerly endemic areas where malaria transmission has declined, levels of population immunity to Plasmodium falciparum provide information on continued malaria transmission and potentially susceptible populations. Traditional techniques for measuring serological responses to P. falciparum antigens use plasma or dried blood spots (DBS). These invasive procedures pose...
Background More than half of malaria cases in Zimbabwe are concentrated in Manicaland Province, where seasonal malaria epidemics occur despite intensified control strategies. Recently, high levels of pyrethroid and carbamate resistance were detected in Anopheles funestus, the major malaria vector in eastern Zimbabwe. In response, a single round of indoor residual spraying (IRS...
Background Asymptomatic reservoirs of malaria parasites are common yet are difficult to detect, posing a problem for malaria control. If control programmes focus on mosquito control and treatment of symptomatic individuals only, malaria can quickly resurge if interventions are scaled back. Foci of parasite populations must be identified and treated. Therefore, an active case...
Asymptomatic reservoirs of malaria parasites are common yet are difficult to detect, posing a problem for malaria control. If control programmes focus on mosquito control and treatment of symptomatic individuals only, malaria can quickly resurge if interventions are scaled back. Foci of parasite populations must be identified and treated. Therefore, an active case detection...
Background Malaria elimination will require that both symptomatic- and asymptomatic-infected persons be identified and treated. However, well-characterized, individual-level risk factors for malaria may not be valid in regions with declining malaria transmission. Changes in individual-level correlates of malaria infection were evaluated over three years in a region of declining...
