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Mini-Margin Nephron Sparing Surgery for Renal Cell Carcinoma 4 cm or Less

Objectives. To explore the safety and efficacy of mini-margin nephron sparing surgery (NSS) for renal cell carcinoma (RCC) 4 cm or less. Methods. Total of 389 cases of RCC 4 cm or less with normal contralateral kidneys were included in the study, including 135 cases treated by mini-margin NSS, 98 by 1 cm-NSS and 156 by radical nephrectomy (RN). The clinical results were followed...

An Efficient Algorithm for Haplotype Inference on Pedigrees with a Small Number of Recombinants

Combinatorial (or rule-based) methods for inferring haplotypes from genotypes on a pedigree have been studied extensively in the recent literature. These methods generally try to reconstruct the haplotypes of each individual so that the total number of recombinants is minimized in the pedigree. The problem is NP-hard, although it is known that the number of recombinants in a...

Hydrogenolysis of glycerol aqueous solution to glycols over Ni–Co bimetallic catalyst: effect of ceria promoting

A series of Ni–Co bimetallic catalysts supported on γ-Al2O3 with different Ni/Co mass ratio were prepared by incipient wetness impregnation method for glycerol hydrogenolysis. The catalyst with a Ni/Co mass ratio of 1:3 (denoted as Ni1Co3) exhibited the highest conversion. The performance was compared with that of catalysts promoted by Ce. Moreover, the addition of Ce showed a...

Effect of ZnO incorporation on Cu–Ni/Al2O3 catalyst for glycerol hydrogenolysis in the absence of added hydrogen

A series of Cu–Ni bimetallic catalysts were developed and used for glycerol hydrogenolysis to produce 1,2-propanediol in the absence of added hydrogen along with the isopropanol as hydrogen donor. The monometallic Cu catalyst can catalyze the dehydrogenation of isopropanol effectively, but the Cu species would be oxidized to Cu+ which led to the catalyst deactivation. Ni...

Mixed aluminoxanes: efficient cocatalysts for bisphosphineamine/Cr(III) catalyzed ethylene tetramerization toward 1-octene

In this study, we examined catalyst systems comprising chromium(III) chloride tetrahydrofuran, diphenylphosphinoamine (PNP) ligand, and a mixed activator of methylaluminoxane (MAO) and alkylaluminum for the selective tetramerization of ethylene. By comparing the catalytic activities and the selectivities toward 1-hexene and 1-octene, we investigated the effects of various mixed...

Hydrogen: efficient promoter for PNP/Cr(III)/MAO catalyzed ethylene tetramerization toward 1-octene

The effect of hydrogen addition on the catalytic activity and product selectivity of PNP/Cr(III)/MAO catalytic systems for ethylene tetramerization was investigated. The results showed that the catalytic activity could be increased twice and the polymer production could be reduced efficiently through hydrogen addition. It could be inferred from the analysis and characterization...

A New Instrument for Testing Wind Erosion by Soil Surface Shape Change

Wind erosion, a primary cause of soil degeneration, is a problem in arid and semiarid areas throughout the world. Many methods are available to study soil erosion, but there is no an effective method for making quantitative measurements in the field. To solve this problem, we have developed a new instrument that can measure the change in the shape of the soil surface, allowing...

A linear-time algorithm for reconstructing zero-recombinant haplotype configuration on a pedigree

Background When studying genetic diseases in which genetic variations are passed on to offspring, the ability to distinguish between paternal and maternal alleles is essential. Determining haplotypes from genotype data is called haplotype inference. Most existing computational algorithms for haplotype inference have been designed to use genotype data collected from individuals in...

Estimation of allele frequency and association mapping using next-generation sequencing data

Geng Tian Niels Grarup Tao Jiang Gitte Andersen Daniel Witte Torben Jorgensen Torben Hansen Oluf Pedersen Jun Wang Rasmus Nielsen 0 0 Departments of Integrative Biology and Statistics, UC Berkeley

Improving probe set selection for microbial community analysis by leveraging taxonomic information of training sequences

Background Population levels of microbial phylotypes can be examined using a hybridization-based method that utilizes a small set of computationally-designed DNA probes targeted to a gene common to all. Our previous algorithm attempts to select a set of probes such that each training sequence manifests a unique theoretical hybridization pattern (a binary fingerprint) to a probe...

Accurate HLA type inference using a weighted similarity graph

Background The human leukocyte antigen system (HLA) contains many highly variable genes. HLA genes play an important role in the human immune system, and HLA gene matching is crucial for the success of human organ transplantations. Numerous studies have demonstrated that variation in HLA genes is associated with many autoimmune, inflammatory and infectious diseases. However...

MSOAR 2.0: Incorporating tandem duplications into ortholog assignment based on genome rearrangement

Background Ortholog assignment is a critical and fundamental problem in comparative genomics, since orthologs are considered to be functional counterparts in different species and can be used to infer molecular functions of one species from those of other species. MSOAR is a recently developed high-throughput system for assigning one-to-one orthologs between closely related...

Computational prediction of type III secreted proteins from gram-negative bacteria

Background Type III secretion system (T3SS) is a specialized protein delivery system in gram-negative bacteria that injects proteins (called effectors) directly into the eukaryotic host cytosol and facilitates bacterial infection. For many plant and animal pathogens, T3SS is indispensable for disease development. Recently, T3SS has also been found in rhizobia and plays a crucial...

Computational prediction of novel non-coding RNAs in Arabidopsis thaliana

Background Non-coding RNA (ncRNA) genes do not encode proteins but produce functional RNA molecules that play crucial roles in many key biological processes. Recent genome-wide transcriptional profiling studies using tiling arrays in organisms such as human and Arabidopsis have revealed a great number of transcripts, a large portion of which have little or no capability to encode...

OligoSpawn: a software tool for the design of overgo probes from large unigene datasets

Background Expressed sequence tag (EST) datasets represent perhaps the largest collection of genetic information. ESTs can be exploited in a variety of biological experiments and analysis. Here we are interested in the design of overlapping oligonucleotide (overgo) probes from large unigene (EST-contigs) datasets. Results OLIGOSPAWN is a suite of software tools that offers two...

Preoperative serum CA125: a useful marker for surgical management of endometrial cancer

Background Surgery plays an important role in the management of endometrial cancer at all stages, particularly early clinical stage. There are still many unanswered questions regarding optimal surgical management of endometrial cancer, particularly regarding which patients should undergo lymphadenectomy. The aim of this study was to evaluate the role of preoperative cancer...

Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility

Background Genetic variations in DNA double-strand break repair genes can influence the ability of a cell to repair damaged DNA and alter an individual’s susceptibility to cancer. We studied whether polymorphisms in DNA double-strand break repair genes are associated with an increased risk of glioma development. Methods We genotyped 10 potentially functional single nucleotide...

Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case–control study

Background The oxidative stress mechanism is of particular interest in the pathogenesis of glioma, given the high rate of oxygen metabolism in the brain. Potential links between polymorphisms of antioxidant genes and glioma risk are currently unknown. We therefore investigated the association between polymorphisms in antioxidant genes and glioma risk. Methods We examined 16...

Sentinel lymph node biopsy as guidance for radical trachelectomy in young patients with early stage cervical cancer

Background The purpose of this study was to assess the feasibility and accuracy of sentinel lymph nodes (SLNs) detection using 99mTc phytate in predicting pelvic lymph nodes status for radical abdominal trachelectomy (RAT) in patients with early stage cervical cancer. Methods Sixty-eight women with stage IA2-IB1 cervical cancer and scheduled to undergo fertility-sparing surgery...