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Cross-sectional estimates revealed high HIV incidence in Botswana rural communities in the era of successful ART scale-up in 2013-2015

Novitsky. Formal analysis: Sikhulile Moyo, Simani Gaseitsiwe, Vlad Novitsky. Funding acquisition: Shahin Lockman, Max Essex. Investigation: Sikhulile Moyo, Simani Gaseitsiwe, Terence Mohammed, Molly ... Chakalisa, Tendani Gaolathe, Mompati O. Mmalane, Refeletswe Lebelonyane, Janet Moore, Joseph M. Makhema. Supervision: Simani Gaseitsiwe, Terence Mohammed, Molly Pretorius Holme, Lucy Mupfumi, Etienne Kadima

Molecular characterisation of hepatitis B virus in HIV-1 subtype C infected patients in Botswana

Background Hepatitis B virus (HBV) is a major global health problem especially in sub-Saharan Africa and in East Asia. Ten hepatitis B virus genotypes have been described that differ by geographic distribution, disease progression, and response to treatment. Escape mutations within the surface open reading frame (ORF) affect HBV antigenicity leading to failures in diagnosis...

Immune Activation Markers in Peripartum Women in Botswana: Association with Feeding Strategy and Maternal Morbidity

Hormone levels shift the immune state in HIV-uninfected pregnant and breastfeeding women away from Th1 responses and toward regulation to permit fetal tolerance. Limited data exist on inflammation during pregnancy or postpartum in HIV-infected women, though certain inflammatory markers are associated with adverse health outcomes among HIV-infected persons. We measured hsCRP, D...