Advanced search    

Search: authors:"Terho Heikkinen"

9 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Clinical and Socioeconomic Burden of Respiratory Syncytial Virus Infection in Children

Background. Vaccines and antivirals against respiratory syncytial virus (RSV) are being developed, but there are scarce data on the full impact of RSV infection on outpatient children. Methods. We analyzed the burden of RSV illness in a prospective cohort study of children aged ≤13 years during 2 consecutive respiratory seasons in Turku, Finland (2231 child-seasons of follow-up). ...

The Clinical Impact and Cost Effectiveness of Quadrivalent Versus Trivalent Influenza Vaccination in Finland

member of AstraZeneca advisory boards and received funding for research projects. Terho Heikkinen has given a lecture at an academic symposium organized by AstraZeneca but was not compensated for his work ... model, drafted the manuscript, and approved the final version. Alfred Sackeyfio assisted with interpretation of the results, critically revised the manuscript, and approved the final version. Terho

Impact of Influenza B Lineage-Level Mismatch Between Trivalent Seasonal Influenza Vaccines and Circulating Viruses, 1999–2012

Background. Influenza B virus strains in trivalent influenza vaccines are frequently mismatched to the circulating B strains, but the population-level impact of such mismatches is unknown. We assessed the impact of vaccine mismatch on the epidemiology of influenza B during 12 recent seasonal outbreaks of influenza in Finland. Methods. We analyzed all available nationwide data on ...

Burden of paediatric influenza in Western Europe: a systematic review

Background Influenza illness in children causes significant clinical and economic burden. Although some European countries have adopted influenza immunisation policies for healthy children, the debate about paediatric influenza vaccination in most countries of the European Union is ongoing. Our aim was to summarise influenza burden (in terms of health outcomes and economic burden) ...

Early Oseltamivir Treatment of Influenza in Children 1–3 Years of Age: A Randomized Controlled Trial

Background. Oseltamivir provides modest clinical benefits to children with influenza when started within 48 hours of symptom onset. The effectiveness of oseltamivir could be substantially greater if the treatment were started earlier during the course of the illness. Methods. We carried out a randomized, double-blind, placebo-controlled trial of the efficacy of oseltamivir started ...

Accuracy of Clinical Diagnosis of Influenza in Outpatient Children

In a prospective study, children 13 years of age with respiratory infections were examined. At each visit, a nasal swab specimen was obtained for the detection of influenza, and the physician recorded his or her opinion on whether the child had influenza. Among 2288 infections, the overall sensitivity of the clinical diagnosis of influenza was 38% and the positive predictive value ...

Microbiology of Acute Otitis Media in Children with Tympanostomy Tubes: Prevalences of Bacteria and Viruses

Background. Bacteria are found in 50%–90% of cases of acute otitis media (AOM) with or without otorrhea, and viruses are found in 20%–49% of cases. However, for at least 15% of patients with AOM, the microbiological etiology is never determined. Our aim was to specify the full etiology of acute middle ear infection by using modern microbiological methods concomitantly for bacterial ...

How to optimise the coverage rate of infant and adult immunisations in Europe

Heinz-J Schmitt 3 Robert Booy 1 Robert Aston 0 Pierre Van Damme 7 R Fabian Schumacher 6 Magda Campins 5 Carlos Rodrigo 4 Terho Heikkinen 9 Catherine Weil-Olivier 8 Adam Finn 2 Per Olcn 11 David

Burden of Influenza in Children in the Community

Background. Influenza vaccination of healthy children is encouraged because children are frequently hospitalized for influenza-attributable illnesses. However, most children with influenza are treated as outpatients, and scarce data are available on the burden of influenza in these children. Methods. We performed a prospective study of respiratory infections in preenrolled cohorts ...