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The ribosomal transcription units of Haplorchis pumilio and H. taichui and the use of 28S rDNA sequences for phylogenetic identification of common heterophyids in Vietnam

Background Heterophyidiasis is now a major public health threat in many tropical countries. Species in the trematode family Heterophyidae infecting humans include Centrocestus formosanus, Haplorchis pumilio, H. taichui, H. yokogawai, Procerovum varium and Stellantchasmus falcatus. For molecular phylogenetic and systematic studies on trematodes, we need more prospective markers for ...

Simultaneous discovery of cancer subtypes and subtype features by molecular data integration

Motivation: Subtyping cancer is key to an improved and more personalized prognosis/treatment. The increasing availability of tumor related molecular data provides the opportunity to identify molecular subtypes in a data-driven way. Molecular subtypes are defined as groups of samples that have a similar molecular mechanism at the origin of the carcinogenesis. The molecular ...

Development and evaluation of a non-ribosomal random PCR and next-generation sequencing based assay for detection and sequencing of hand, foot and mouth disease pathogens

Background Hand, foot and mouth disease (HFMD) has become a major public health problem across the Asia-Pacific region, and is commonly caused by enterovirus A71 (EV-A71) and coxsackievirus A6 (CV-A6), CV-A10 and CV-A16. Generating pathogen whole-genome sequences is essential for understanding their evolutionary biology. The frequent replacements among EV serotypes and a limited ...

A Study on High Performance Fine-Grained Concrete Containing Rice Husk Ash

Ha Thanh Le Sang Thanh Nguyen Horst-Michael Ludwig Rice husk ash (RHA) is classified as a highly reactive pozzolan. It has a very high silica content similar to that of silica fume (SF). Using less

Conservation of σ28-Dependent Non-Coding RNA Paralogs and Predicted σ54-Dependent Targets in Thermophilic Campylobacter Species

Assembly of flagella requires strict hierarchical and temporal control via flagellar sigma and anti-sigma factors, regulatory proteins and the assembly complex itself, but to date non-coding RNAs (ncRNAs) have not been described to regulate genes directly involved in flagellar assembly. In this study we have investigated the possible role of two ncRNA paralogs (CjNC1, CjNC4) in ...

A feasible MapReduce peer-to-peer framework for distributed computing applications

This article presents a MapReduce Peer-to-Peer (P2P) framework that enables a MapReduce implementation on P2P networks to support a class of MapReduce-based computing applications. This framework can be useful for researchers who cannot afford expensive and dedicated clusters for infrequent demands of solving distributed computing problems. The framework also allows Internet users ...

A dengue outbreak on a floating village at Cat Ba Island in Vietnam

Background A dengue outbreak in an ecotourism destination spot in Vietnam, from September to November 2013, impacted a floating village of fishermen on the coastal island of Cat Ba. The outbreak raises questions about how tourism may impact disease spread in rural areas. Methods Epidemiological data were obtained from the Hai Phong Preventive Medical Center (PMC), including case ...

Defined α-synuclein prion-like molecular assemblies spreading in cell culture

Background α-Synuclein (α-syn) plays a central role in the pathogenesis of synucleinopathies, a group of neurodegenerative disorders that includes Parkinson disease, dementia with Lewy bodies and multiple system atrophy. Several findings from cell culture and mouse experiments suggest intercellular α-syn transfer. Results Through a methodology used to obtain synthetic mammalian ...

HIGEDA: a hierarchical gene-set genetics based algorithm for finding subtle motifs in biological sequences

Thanh Le 1 Tom Altman 1 Katheleen Gardiner 0 Associate Editor: Limsoon Wong 0 Department of Pediatrics, Computational Biosciences, Human Medical Genetics and Neuroscience Programs, University of

Diagnostic Accuracy of Microscopic Observation Drug Susceptibility (MODS) Assay for Pediatric Tuberculosis in Hanoi, Vietnam

Introduction icroscopic Observation Drug Susceptibility (MODS) has been shown to be an effective and rapid technique for early diagnosis of tuberculosis (TB). Thus far only a limited number of studies evaluating MODS have been performed in children and in extra-pulmonary tuberculosis. This study aims to assess relative accuracy and time to positive culture of MODS for TB diagnosis ...

Evidence That Graft-Site Candidiasis after Kidney Transplantation Is Acquired during Organ Recovery: A Multicenter Study in France

Background.Infections of renal grafts with Candida species can induce life-threatening complications in the recipient. Methods.A 9-year retrospective study involving all of the transplant centers in France was designed to determine the incidence, origin, characteristics, and outcome of graft-site candidiasis that occurred after kidney transplantation. Yeasts cultured from ...