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Non-linear parameters of specific resistance loops to characterise obstructive airways diseases

Background Specific resistance loops appear in different shapes influenced by different resistive properties of the airways, yet their descriptive ability is compressed to a single parameter - its slope. We aimed to develop new parameters reflecting the various shapes of the loop and to explore their potential in the characterisation of obstructive airways diseases. Methods Our ...

The effects of a physical activity counseling program after an exacerbation in patients with Chronic Obstructive Pulmonary Disease: a randomized controlled pilot study

Background In some patients with COPD, the disease is characterized by exacerbations. Severe exacerbations warrant a hospitalization, with prolonged detrimental effects on physical activity. Interventions after an exacerbation may improve physical activity, with longstanding health benefits. Physical activity counseling and real-time feedback were effective in stable COPD. No ...

The Minimal Important Difference in Physical Activity in Patients with COPD

Background Changes in physical activity (PA) are difficult to interpret because no framework of minimal important difference (MID) exists. We aimed to determine the minimal important difference (MID) in physical activity (PA) in patients with Chronic Obstructive Pulmonary Disease and to clinically validate this MID by evaluating its impact on time to first COPD-related ...

Physical Activity Counselling during Pulmonary Rehabilitation in Patients with COPD: A Randomised Controlled Trial

Background Pulmonary rehabilitation programs only modestly enhance daily physical activity levels in patients with chronic obstructive pulmonary disease (COPD). This randomised controlled trial investigates the additional effect of an individual activity counselling program during pulmonary rehabilitation on physical activity levels in patients with moderate to very severe COPD. ...

Airways resistance and specific conductance for the diagnosis of obstructive airways diseases

Background Airway resistance (R AW ) and specific airway conductance (sG AW ) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of R AW and sG AW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. Methods 976 ...

Physical Activity Characteristics across GOLD Quadrants Depend on the Questionnaire Used

, Lausanne, Switzerland; Margaret Tabberer: GlaxoSmithKline, Uxbridge, UK; Thierry Troosters, Wim Janssens, Fabienne Dobbels, Chris Burtin and Hans Van Remoortel: Katholieke Universiteit Leuven, Leuven

Improving physical activity in COPD: towards a new paradigm

: Zutphen physical activity questionnaire. Competing interests Thierry Troosters received speakers fees from Novartis, Boehringer Ingelheim, Chiesi, AstraZeneca. He is the scientific coordinator of PROactive

Impaired Postural Control Reduces Sit-to-Stand-to-Sit Performance in Individuals with Chronic Obstructive Pulmonary Disease

Background Functional activities, such as the sit-to-stand-to-sit (STSTS) task, are often impaired in individuals with chronic obstructive pulmonary disease (COPD). The STSTS task places a high demand on the postural control system, which has been shown to be impaired in individuals with COPD. It remains unknown whether postural control deficits contribute to the decreased STSTS ...

Impact of exacerbations of cystic fibrosis on muscle strength

Background Adult patients with cystic fibrosis have peripheral muscle weakness, which is related to exercise intolerance and poor prognosis. The influence of acute exacerbations on muscle strength has been poorly studied. This study aimed to investigate whether quadriceps force (QF), as assessed with an involuntary technique, changes during intravenous antibiotics therapy (IVAT) ...

Moderate Intense Physical Activity Depends on Selected Metabolic Equivalent of Task (MET) Cut-Off and Type of Data Analysis

BackgroundAccelerometry data are frequently analyzed without considering whether moderate-to-vigorous physical activities (MVPA) were performed in bouts of >10 minutes as defined in most physical activity guidelines. We aimed i) to quantify MVPA by using different commonly-applied physical activity guidelines, ii) to investigate the effect of bouts versus non-bouts analysis, and ...

Proprioceptive Changes Impair Balance Control in Individuals with Chronic Obstructive Pulmonary Disease

Introduction Balance deficits are identified as important risk factors for falling in individuals with chronic obstructive pulmonary disease (COPD). However, the specific use of proprioception, which is of primary importance during balance control, has not been studied in individuals with COPD. The objective was to determine the specific proprioceptive control strategy during ...

Two Distinct Chronic Obstructive Pulmonary Disease (COPD) Phenotypes Are Associated with High Risk of Mortality

Rationale In COPD patients, mortality risk is influenced by age, severity of respiratory disease, and comorbidities. With an unbiased statistical approach we sought to identify clusters of COPD patients and to examine their mortality risk. Methods Stable COPD subjects (n = 527) were classified using hierarchical cluster analysis of clinical, functional and imaging data. The ...

Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial

Rationale Pulmonary rehabilitation is an important treatment for patients with Chronic Obstructive Pulmonary Disease, who are often vitamin D deficient. As vitamin D status is linked to skeletal muscle function, we aimed to explore if high dose vitamin D supplementation can improve the outcomes of rehabilitation in Chronic Obstructive Pulmonary Disease. Material and methods This ...

The minimal important difference of the pulmonary functional status and dyspnea questionnaire in patients with severe chronic obstructive pulmonary disease

Background The modified version of the Pulmonary Functional Status and Dyspnea Questionnaire (PFSDQ-M) is used in patients with COPD to obtain information about their functional status. It consists of 3 components (change in activities, dyspnea and fatigue) ranging from 0 to 100 and has been shown to be responsive following pulmonary rehabilitation (PR). The interpretation of ...

Level of daily physical activity in individuals with COPD compared with healthy controls

Background Persons with Chronic Obstructive Pulmonary Disease (COPD), performing some level of regular physical activity, have a lower risk of both COPD-related hospital admissions and mortality. COPD patients of all stages seem to benefit from exercise training programs, thereby improving with respect to both exercise tolerance and symptoms of dyspnea and fatigue. Physical ...

Validity of Six Activity Monitors in Chronic Obstructive Pulmonary Disease: A Comparison with Indirect Calorimetry

of the PROactive consortium for the outstanding contribution to this work. PROactive consortium: Chiesi Farmaceutici S.A.: Caterina Brindicci, Tim Higenbottam; Katholieke Universiteit Leuven: Thierry ... Troosters, Fabienne Dobbels; Glaxo Smith Kline: Margaret X. Tabberer; University of Edinburgh, Old College South Bridge: Roberto A Rabinovich, William McNee; Thorax Research Foundation, Athens: Ioannis

An official American Thoracic Society/European Respiratory Society statement: research questions in COPD

James K. Stoller Donald P. Tashkin Thierry Troosters Geert M. Verleden Johny Verschakelen Jorgen Vestbo John W. Walsh George R. Washko Robert A. Wise Emiel F.M. Wouters Richard L. ZuWallack on behalf of ... Siafakas, Don D. Sin, Joan B. Soriano, James K. Stoller, Donald P. Tashkin, Thierry Troosters, Geert M. Verleden, Johny Verschakelen, Jorgen Vestbo, John W. Walsh, George R. Washko, Robert A. Wise, Emiel F

Validity of activity monitors in health and chronic disease: a systematic review

: Chiesi Farmaceutici S.A.: Caterina Brindicci, Tim Higenbottam; Katholieke Universiteit Leuven: Thierry Troosters, Fabienne Dobbels, Marc Decramer; Glaxo Smith Kline: Margaret X. Tabberer; University of