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Search: authors:"Thomas Kühne"

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Editorial to the theme issue on multi-level modeling

: 46 ( 2014 ) Thomas Kühne is an Associate Professor at Victoria University of Wellington, New Zealand . Prior to that he was an Assistant Professor at the Technische Universität Darmstadt, Germany, an

Eltrombopag: an update on the novel, non-peptide thrombopoietin receptor agonist for the treatment of immune thrombocytopenia

Immune thrombocytopenia (ITP) is characterised by a transient or persistent decrease in platelets accompanied by an increased risk of bleeding, which can have a significant negative impact on patients’ health-related quality of life. The condition has long been associated with an increased rate of immune-mediated platelet destruction, and traditional treatments have targeted the ...

Neutrality, Compensation, and Negative Selection during Evolution of B-Cell Development Transcriptomes

B cells develop in the mammalian bone marrow through a sequence of precursor stages, which can be ordered by the recombination status of their immunoglobulin loci. This developmental pathway is functionally similar between mice and man. However, whether this similarity is based on usage of the same genes is unknown. We show that large-scale gene expression patterns differ ...