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18 papers found.
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Progress in the Diagnosis of Invasive Fungal Disease in Children

research grant from Gilead, organised and participated in CME with support from Gilead and Pfizer, and provided consultancy services for Basilea and Gilead. Thomas Lehrnbecher has received a research grant

Langzeitprognose und Spättodesfälle bei Kindern mit Krebserkrankungen

. Möglicherweise kann die Weiterentwicklung von zielgerichteten Therapien das Problem der Spätfolgen weiter verringern, wobei Ergebnisse jedoch erst in Jahrzehnten zu erwarten sind. Prof. Dr. Thomas Lehrnbecher

Oft vergessen: Impfungen bei Kindern nach Krebserkrankungen

notwendig ist – was jedoch einen bedeutenden Kostenfaktor darstellt sowie die Lebensqualität der kleinen Patienten beein§usst (venöse Blutentnahme). Prof. Dr. Thomas Lehrnbecher

Thrombopoietin-Mimetika als neue Behandlungsoption bei Kindern mit ITP?

. Thomas Lehrnbecher Kommentar: HBoV sind nach RSV und Rhinoviren die dritthäufigsten Viren, die bei kleinen Kindern mit einer obstruktiven Bronchitis gefunden werden. Bei etwa 70–90 % der Kinder mit akutem

Helicobacter-Eradikation bei chronischer ITP?

ansonsten standardmäßig empfohlene Biopsie zur Resistenzbestimmung des Erregers bei Kindern mit Thrombozytopenie kritisch zu diskutieren. Prof. Dr. Thomas Lehrnbecher

Anti-infektiöse Supportivmaßnahmen I: Uneinigkeit bei den Ärzten

eingesetzt werden. Prof. Dr. Thomas Lehrnbecher Lehrnbecher T et al. International variations in infection supportive care practices for paediatric patients with acute myeloid leukaemia. Br J Haematol 2009

Auffrischimpfungen nach Chemotherapie - Wunsch und Wirklichkeit

australisches Forscherteam untersuchte, wie viele Kinder wirklich entsprechend der australischen Empfehlungen geimpft werden. Prof. Dr. Thomas Lehrnbecher Crawford et al. Survivors of childhood cancer: an

Wird das Risiko für eine Leukämie durch Impfungen erhöht?

Amy MacArthur bestätigt werden [Am J Epidemiol 2008; 167: 598–606]. Prof. Dr. Thomas Lehrnbecher Mallol-Mesnard N et al. Vaccination and the risk of childhood acute leukaemia: the ESCALE study (SFCE

Einfluss einer nicht sterilen Umgebung

bei Patienten weiter erhöht. Prof. Dr. Thomas Lehrnbecher Tabori U et al. Low prevalence of complications in severe neutropenic children with cancer in the unprotected environment of an overnight camp ... möglicherweise einen nachhaltigen Effekt auf die Effektivität einer Maßnahme haben. Prof. Dr. Thomas Lehrnbecher

Todesraten nach Infektionen

notwendig, mit denen deutlich mehr Patienten und Komplikationen erfasst werden könnten. Prof. Dr. Thomas Lehrnbecher Bate J et al. Infection-related mortality in children with malignancy in England and Wales

Ohne Compliance keine effektive Prävention

Untergruppen gemacht werden, da auch andere Nebenwirkungen der Chemotherapie, wie z. B. eine begleitende Mukositis, die Infektionsgefahr bei Patienten weiter erhöht. Prof. Dr. Thomas Lehrnbecher Tabori U et al ... Maßnahme haben. Prof. Dr. Thomas Lehrnbecher Lehrnbecher T et al. Compliance with antiinfective preventive measures: a multicentre survey among paediatric oncology patients. Eur J Cancer 2008; 44: 1861–5

Updated Systematic Review and Meta-Analysis of the Performance of Risk Prediction Rules in Children and Young People with Febrile Neutropenia

Introduction Febrile neutropenia is a common and potentially life-threatening complication of treatment for childhood cancer, which has increasingly been subject to targeted treatment based on clinical risk stratification. Our previous meta-analysis demonstrated 16 rules had been described and 2 of them subject to validation in more than one study. We aimed to advance our knowledge ...

Characterization of the Cellular Immune Responses to Rhizopus oryzae With Potential Impact on Immunotherapeutic Strategies in Hematopoietic Stem Cell Transplantation

Infections due to mucormycetes have a poor outcome, in particular in allogeneic hematopoietic stem cell transplantation (HSCT). In order to evaluate the cellular host response against mucormycetes, we enriched and cultivated anti–Rhizopus oryzae T cells from healthy individuals. These cells were characterized as memory/effector TH1 cells, they proliferated upon restimulation, they ...

Systematic review and meta-analysis of the value of initial biomarkers in predicting adverse outcome in febrile neutropenic episodes in children and young people with cancer

Background Febrile neutropenia is a frequently occurring and occasionally life-threatening complication of treatment for childhood cancer. Many biomarkers have been proposed as predictors of adverse events. We aimed to undertake a systematic review and meta-analysis to summarize evidence on the discriminatory ability of initial serum biomarkers of febrile neutropenic episodes in ...

Human Natural Killer Cells Exhibit Direct Activity Against Aspergillus fumigatus Hyphae, But Not Against Resting Conidia

Because natural killer (NK) cells kill tumor cells and combat infections, there is growing interest in adoptively transferring NK cells to hematopoietic stem cell recipients. Unfortunately, in humans, the activity of NK cells against Aspergillus species, the major cause of invasive fungal infection in stem cell recipients, are poorly characterized. Our results show that ...

Sequential Anti-Cytomegalovirus Response Monitoring May Allow Prediction of Cytomegalovirus Reactivation after Allogeneic Stem Cell Transplantation

Background Reconstitution of cytomegalovirus-specific CD3+CD8+ T cells (CMV-CTLs) after allogeneic hematopoietic stem cell transplantation (HSCT) is necessary to bring cytomegalovirus (CMV) reactivation under control. However, the parameters determining protective CMV-CTL reconstitution remain unclear to date. Design and Methods In a prospective tri-center study, CMV-CTL ...

Failure of Interferon γ to Induce the Anti-Inflammatory Interleukin 18 Binding Protein in Familial Hemophagocytosis

Background Familial hemophagocytosis (FHL) is a rare disease associated with defects in proteins involved in CD8+ T-cell cytotoxicity. Hyperactivation of immune cells results in a perilous, Th1-driven cytokine storm. We set out to explore the regulation of cytokines in an FHL patient who was clinically stable on low-dose immunosuppressive therapy after bone marrow transplantation ...