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Core signaling pathways in ovarian cancer stem cell revealed by integrative analysis of multi-marker genomics data

to thank colleagues in Biomedical Informatics Department for the helpful discussions. Author Contributions Conceptualization: Fuhai Li. Data curation: Tianyu Zhang, Jielin Xu, Qi-En Wang, Fuhai Li ... . Methodology: Tianyu Zhang, Jielin Xu, Siyuan Deng, Fengqi Zhou, Jin Li, Liwei Zhang, Lang Li, Qi-En Wang, Fuhai Li. Writing ± original draft: Tianyu Zhang, Qi-En Wang, Fuhai Li. Writing ± review & editing

In situ synthesis of silver/chemically reduced graphene nanocomposite and its use for low temperature conductive paste

In this work, we succeeded in the synthesis of Ag/chemically reduced graphene (Ag/G) nanocomposite by a facile in situ one-pot solvothermal route. X-ray diffraction, X-ray photoelectron spectroscopy, Raman spectra and Fourier transform infrared spectroscopy results revealed the formation of Ag and the reduction of graphite oxide to graphene during the one-pot process. Scanning...

In situ synthesis of silver/chemically reduced graphene nanocomposite and its use for low temperature conductive paste

In this work, we succeeded in the synthesis of Ag/chemically reduced graphene (Ag/G) nanocomposite by a facile in situ one-pot solvothermal route. X-ray diffraction, X-ray photoelectron spectroscopy, Raman spectra and Fourier transform infrared spectroscopy results revealed the formation of Ag and the reduction of graphite oxide to graphene during the one-pot process. Scanning...

General Theory for Integrated Analysis of Growth, Gene, and Protein Expression in Biofilms

A theory for analysis and prediction of spatial and temporal patterns of gene and protein expression within microbial biofilms is derived. The theory integrates phenomena of solute reaction and diffusion, microbial growth, mRNA or protein synthesis, biomass advection, and gene transcript or protein turnover. Case studies illustrate the capacity of the theory to simulate...

mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile

It has been established that mammalian target of Rapamycin (mTOR) inhibitors have anti-inflammatory effects in models of experimental colitis. However, the underlying mechanism is largely unknown. In this research, we investigate the anti-inflammatory effects of AZD8055, a potent mTOR inhibitor, on T cell response in dextran sulfate sodium (DSS)-induced colitis in mice, a...

Rapid, Serial, Non-invasive Assessment of Drug Efficacy in Mice with Autoluminescent Mycobacterium ulcerans Infection

Background Buruli ulcer (BU) caused by Mycobacterium ulcerans is the world's third most common mycobacterial infection. There is no vaccine against BU and surgery is needed for patients with large ulcers. Although recent experience indicates combination chemotherapy with streptomycin and rifampin improves cure rates, the utility of this regimen is limited by the 2-month duration...

Engineering More Stable, Selectable Marker-Free Autoluminescent Mycobacteria by One Step

In our previous study, we demonstrated that the use of the autoluminescent Mycobacterium tuberculosis as a reporter strain had the potential to drastically reduce the time, effort, animals and costs consumed in evaluation of the activities of drugs and vaccines in live mice. However, the strains were relatively unstable and lost reporter with time without selection. The kanamycin...

Overexpression of EMMPRIN Isoform 2 Is Associated with Head and Neck Cancer Metastasis

Extracellular matrix metalloproteinase inducer (EMMPRIN), a plasma membrane protein of the immunoglobulin (Ig) superfamily, has been reported to promote cancer cell invasion and metastasis in several human malignancies. However, the roles of the different EMMPRIN isoforms and their associated mechanisms in head and neck cancer progression remain unknown. Using quantitative real...

Autoluminescent Mycobacterium tuberculosis for Rapid, Real-Time, Non-Invasive Assessment of Drug and Vaccine Efficacy

of Drug and Vaccine Efficacy Tianyu Zhang Si-Yang Li Eric L. Nuermberger Anil Kumar Tyagi, University of Delhi, India Preclinical efforts to discover and develop new drugs and vaccines for