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43 papers found.
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Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults

Apolipoprotein E (APOE) and sortilin-related receptor (SORL1) genes act on the same metabolic pathway and have been associated with Alzheimer’s disease (AD) characterized by hippocampal impairment. Although the effects of APOE on hippocampal resting-state functional connectivity (rsFC) have been reported, the main effects of SORL1 and SORL1 × APOE interactions on hippocampal rsFC ...

Interactions of genetic variants reveal inverse modulation patterns of dopamine system on brain gray matter volume and resting-state functional connectivity in healthy young adults

Different genotypic combinations of COMT and DRD2 can generate multiple subgroups with different levels of dopamine signaling. Its modulations on brain properties can be investigated by analyzing the combined gene effects of COMT and DRD2. However, the inherent association between modulation patterns of the dopamine system on structural and functional properties of the brain ...

The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture

The human brain atlases that allow correlating brain anatomy with psychological and cognitive functions are in transition from ex vivo histology-based printed atlases to digital brain maps providing multimodal in vivo information. Many current human brain atlases cover only specific structures, lack fine-grained parcellations, and fail to provide functionally important connectivity ...

Association Study of N-Methyl-D-Aspartate Receptor Subunit 2B (GRIN2B) Polymorphisms and Schizophrenia Symptoms in the Han Chinese Population

Schizophrenia (SZ) is a common and complex psychiatric disorder that has a significant genetic component. The glutamatergic system is the major excitatory neurotransmitter system in the central nervous system, and is mediated by N-methyl-D-aspartate (NMDA) receptors. Disturbances in this system have been hypothesized to play a major role in SZ pathogenesis. Several studies have ...

How Does B-Value Affect HARDI Reconstruction Using Clinical Diffusion MRI Data?

Background A number of imaging factors can affect the orientation distribution function (ODF) reconstruction in high angular resolution diffusion imaging (HARDI). The aim of this study was to investigate the effect of the b-value on the HARDI reconstruction and to seek for the appropriate b-value for ODF reconstruction from clinical HARDI data. Methods Diffusion MRI data with ...

Alterations in white matter fractional anisotropy in subsyndromal perimenopausal depression

Jiang Jinbei Zhang 0 0 Department of Psychiatry, the Third Affiliated Hospital of Sun Yat-sen University , Guangzhou 510630 , China 1 Mental Health Institute of the Second Xiangya Hospital, National

Connectivity-Based Parcellation of the Human Posteromedial Cortex

Regional structural and functional variations in the posteromedial cortex (PMC) have been found in both animals and humans, strongly suggesting the presence of subdivisions. However, there is no consensus on how to subdivide the human PMC. Here, we investigated the anatomical parcellation scheme and the connectivity pattern of each subdivision of the human PMC using diffusion ...

HMDD v2.0: a database for experimentally supported human microRNA and disease associations

The Human microRNA Disease Database (HMDD; available via the Web site at http://cmbi.bjmu.edu.cn/hmdd and http://202.38.126.151/hmdd/tools/hmdd2.html) is a collection of experimentally supported human microRNA (miRNA) and disease associations. Here, we describe the HMDD v2.0 update that presented several novel options for users to facilitate exploration of the data in the database. ...

The Development of Visual Areas Depends Differently on Visual Experience

Visual experience plays an important role in the development of the visual cortex; however, recent functional imaging studies have shown that the functional organization is preserved in several higher-tier visual areas in congenitally blind subjects, indicating that maturation of visual areas depend unequally on visual experience. In this study, we aim to validate this hypothesis ...

Impaired Long Distance Functional Connectivity and Weighted Network Architecture in Alzheimer's Disease

Alzheimer's disease (AD) is increasingly recognized as a disconnection syndrome, which leads to cognitive impairment due to the disruption of functional activity across large networks or systems of interconnected brain regions. We explored abnormal functional magnetic resonance imaging (fMRI) resting-state dynamics, functional connectivity, and weighted functional networks, in a ...

Catechol-O-Methyltransferase Val158Met Polymorphism Modulates Gray Matter Volume and Functional Connectivity of the Default Mode Network

The effect of catechol-O-methyltransferase (COMT) Val158Met polymorphism on brain structure and function has been previously investigated separately and regionally; this prevents us from obtaining a full picture of the effect of this gene variant. Additionally, gender difference must not be overlooked because estrogen exerts an interfering effect on COMT activity. We examined 323 ...

Robust brain parcellation using sparse representation on resting-state fMRI

Resting-state fMRI (rs-fMRI) has been widely used to segregate the brain into individual modules based on the presence of distinct connectivity patterns. Many parcellation methods have been proposed for brain parcellation using rs-fMRI, but their results have been somewhat inconsistent, potentially due to various types of noise. In this study, we provide a robust parcellation ...

Is Payoff Necessarily Weighted by Probability When Making a Risky Choice? Evidence from Functional Connectivity Analysis

How people make decisions under risk remains an as-yet-unresolved but fundamental question. Mainstream theories about risky decision making assume that the core processes involved in reaching a risky decision include weighting each payoff or reward magnitude by its probability and then summing the outcomes. However, recently developed theories question whether payoffs are ...

Less Efficient Information Transfer in Cys-Allele Carriers of DISC1: A Brain Network Study Based on Diffusion MRI

Previous neuroimaging studies of brain networks have revealed less efficient information transfer in patients with schizophrenia. However, the underlying genetic basis remains largely unexplored. In this study, we investigated the brain anatomical networks of 278 healthy volunteers with different genotypes in the common missense variant (Ser704Cys) of the ...

Sex-Dependent Correlations between the Personality Dimension of Harm Avoidance and the Resting-State Functional Connectivity of Amygdala Subregions

(973 program, No. 2010CB732506). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: Tianzi Jiang is a

The Neuronal Correlates of Digits Backward Are Revealed by Voxel-Based Morphometry and Resting-State Functional Connectivity Analyses

Digits backward (DB) is a widely used neuropsychological measure that is believed to be a simple and effective index of the capacity of the verbal working memory. However, its neural correlates remain elusive. The aim of this study is to investigate the neural correlates of DB in 299 healthy young adults by combining voxel-based morphometry (VBM) and resting-state functional ...

DISC1 Ser704Cys impacts thalamic-prefrontal connectivity

The Disrupted-in-Schizophrenia 1 (DISC1) gene has been thought as a putative susceptibility gene for various psychiatric disorders, and DISC1 Ser704Cys is associated with variations of brain morphology and function. Moreover, our recent diffusion magnetic resonance imaging (dMRI) study reported that DISC1 Ser704Cys was associated with information transfer efficiency in the brain ...

Age of Onset of Blindness Affects Brain Anatomical Networks Constructed Using Diffusion Tensor Tractography

Studying blindness with various onset ages may elucidate the ways that unimodal sensory deprivation at different periods of development shape the human brain. In order to determine the effect of the onset age on brain anatomical networks, we extended a previous study of 17 early blind (EB) subjects with an additional 97 subjects with various onset ages. We constructed binary ...