Advanced search    

Search: authors:"Timothy J. McDonald"

11 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Screening for neonatal diabetes at day 5 of life using dried blood spot glucose measurement

Aims/hypothesis The majority of infants with neonatal diabetes mellitus present with severe ketoacidosis at a median of 6 weeks. The treatment is very challenging and can result in severe neurological sequelae or death. The genetic defects that cause neonatal diabetes are present from birth. We aimed to assess if neonatal diabetes could be diagnosed earlier by measuring glucose in ...

Diagnostic Confusion? Repeat HbA1c for the Diagnosis of Diabetes

Timothy J. McDonald 1 Roderick Warren 0 0 Department of Endocrinology, Royal Devon and Exeter Hospital and University of Exeter Medical School , Exeter, U.K 1 National Institute for Health Research

A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults

OBJECTIVE With rising obesity, it is becoming increasingly difficult to distinguish between type 1 diabetes (T1D) and type 2 diabetes (T2D) in young adults. There has been substantial recent progress in identifying the contribution of common genetic variants to T1D and T2D. We aimed to determine whether a score generated from common genetic variants could be used to discriminate ...

Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes

Aims/hypothesis This study aimed to determine the frequency of residual beta cell function in individuals with long-standing type 1 diabetes who were recruited at diagnosis, and relate this to baseline and current islet autoantibody profile. Methods Two hour post-meal urine C-peptide:creatinine ratio (UCPCR) and islet autoantibodies were measured in samples collected from 144 ...

Most People With Long-Duration Type 1 Diabetes in a Large Population-Based Study Are Insulin Microsecretors

OBJECTIVE Small studies using ultrasensitive C-peptide assays suggest endogenous insulin secretion is frequently detectable in patients with long-standing type 1 diabetes (T1D), but these studies do not use representative samples. We aimed to use the stimulated urine C-peptide-to-creatinine ratio (UCPCR) to assess C-peptide levels in a large cross-sectional, population-based study ...

Erratum to: The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells

Bridget A. Knight Beverley M. Shields Richard J. Brown Andrew T. Hattersley Timothy J. McDonald Erratum to: Diabetologia 0 ) NIHR Exeter Clinical Research Facility, University of Exeter Medical School

The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells

Aims/hypothesis Classically, type 1 diabetes is thought to proceed to absolute insulin deficiency. Recently developed ultrasensitive assays capable of detecting C-peptide under 5 pmol/l now allow very low levels of C-peptide to be detected in patients with long-standing type 1 diabetes. It is not known whether this low-level endogenous insulin secretion responds to physiological ...

EDTA Improves Stability of Whole Blood C-Peptide and Insulin to Over 24 Hours at Room Temperature

Introduction C-peptide and insulin measurements in blood provide useful information regarding endogenous insulin secretion. Conflicting evidence on sample stability and handling procedures continue to limit the widespread clinical use of these tests. We assessed the factors that altered the stability of insulin and C-peptide in blood. Methods We investigated the impact of ...

Urine C-Peptide Creatinine Ratio Is a Noninvasive Alternative to the Mixed-Meal Tolerance Test in Children and Adults With Type 1 Diabetes

RACHEL E.J. BESSER MBBS JOHNNY LUDVIGSSON PHD ANGUS G. JONES MBBS TIMOTHY J. MCDONALD MSC BEVERLEY M. SHIELDS PHD BRIDGET A. KNIGHT PHD ANDREW T. HATTERSLEY DM OBJECTIVE-Stimulated serum C-peptide

Urinary C-Peptide Creatinine Ratio Is a Practical Outpatient Tool for Identifying Hepatocyte Nuclear Factor 1-α/Hepatocyte Nuclear Factor 4-α Maturity-Onset Diabetes of the Young From Long-Duration Type 1 Diabetes

RACHEL E.J. BESSER MBBS MAGGIE H. SHEPHERD PHD TIMOTHY J. MCDONALD MSC BEVERLEY M. SHIELDS PHD BRIDGET A. KNIGHT PHD SIAN ELLARD PHD ANDREW T. HATTERSLEY DM OBJECTIVEHepatocyte nuclear factor 1-a