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6 papers found.
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High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue

Background Squamous cell carcinoma of the tongue (tongue SCC) is a major subtype of head and neck squamous cell carcinoma (HNSCC), which is an intractable cancer under current therapeutics. ARF6 and its effector AMAP1 are often overexpressed in different types of cancers, such as breast cancer and renal cancer, and in these cancers, AMAP1 binds to EPB41L5 to promote invasion, ...

Regulation of osteoclasts by membrane-derived lipid mediators

Tsukasa Oikawa Yukiko Kuroda Koichi Matsuo 0 ) Y. Kuroda K. Matsuo Laboratory of Cell and Tissue Biology, School of Medicine, Keio University , 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan

A Novel Phthalimide Derivative, TC11, Has Preclinical Effects on High-Risk Myeloma Cells and Osteoclasts

Despite the recent advances in the treatment of multiple myeloma (MM), MM patients with high-risk cytogenetic changes such as t(4;14) translocation or deletion of chromosome 17 still have extremely poor prognoses. With the goal of helping these high-risk MM patients, we previously developed a novel phthalimide derivative, TC11. Here we report the further characterization of TC11 ...

IRSp53 Mediates Podosome Formation via VASP in NIH-Src Cells

Podosomes are cellular “feet,” characterized by F-actin-rich membrane protrusions, which drive cell migration and invasion into the extracellular matrix. Small GTPases that regulate the actin cytoskeleton, such as Cdc42 and Rac are central regulators of podosome formation. The adaptor protein IRSp53 contains an I-BAR domain that deforms membranes into protrusions and binds to Rac, ...

Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion

Daisuke Yamazaki 0 Tsukasa Oikawa 0 Tadaomi Takenawa ) 0 0 Department of Biochemistry, Institute of Medical Science, University of Tokyo , 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639 , Japan