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Indian Journal of Gastroenterology: The promises fulfilled and waiting for fulfillment!

Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences , Lucknow 226 014 , India 1 Uday C. Ghoshal - It is a great pleasure for me to take-up the responsibility of the honorary position of the

Pepsinogen-II 100 bp ins/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia

Background Polymorphism in the gene of pepsinogen-II (PG-II) and its serum level are effective biomarkers for terminal differentiation of gastric mucosa into gastritis, intestinal metaplasia (IM), and gastric cancer (GC) in relationship to Helicobacter pylori infection. Methods Genotyping of the PG-II 100 bp insertion/deletion (ins/del) polymorphism was performed in patients with...

Chicago classification of high-resolution esophageal manometry: Is old the gold or is new better?

Uday C. Ghoshal 0 ) Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences , Raebareli Road, Lucknow 226 014, India - High-resolution manometry (HRM), a landmark

Evaluating quality of life of patients with chronic liver disease: quest for a questionnaire

Uday C. Ghoshal 0 Ananya Das 0 0 U. C. Ghoshal Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences , Lucknow 226 014, India 1 ) Arizona Center for Digestive

Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection

BackgroundActivity of cytochrome P450 (CYP), a polymorphic carcinogen-activating enzyme, is exaggerated following Helicobacter pylori infection. We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis.MethodsGenotyping of CYP2E1 (96-bp insertion), CYP1A2 (164A to C), and CYP1A1 (3801C...

Recurrent lower gastrointestinal bleeding from idiopathic ileocolonic varices: a case report

Introduction Varices of the colon are a rare cause of lower gastrointestinal bleeding, usually associated with portal hypertension due to liver cirrhosis or other causes of portal venous obstruction. Idiopathic colonic varices are extremely rare. Recognition of this condition is important as idiopathic colonic varices may be a cause of recurrent lower gastrointestinal bleeding...

Evaluation of antigen detection and polymerase chain reaction for diagnosis of amoebic liver abscess in patients on anti-amoebic treatment

Background Diagnosis of amoebic liver abscess (ALA) in patients on anti-amoebic drugs is difficult. There is scanty data on this issue using Entamoeba histolytica (E. histolytica) lectin antigen and polymerase chain reaction (PCR). We studied utility of lectin antigen, PCR, and IgG antibody in diagnosis of liver abscess in patients on anti-amoebic treatment. Liver aspirate of 200...

Partially responsive celiac disease resulting from small intestinal bacterial overgrowth and lactose intolerance

LT: lactose tolerance test Declaration of competing interests None declared. Authors' contribution Uday C Ghoshal was the clinician involved in the management of these patients, conceived the idea

Indian Society of Gastroenterology consensus statements on Crohn’s disease in India

In 2012, the Indian Society of Gastroenterology’s Task Force on Inflammatory Bowel Diseases undertook an exercise to produce consensus statements on Crohn’s disease (CD). This consensus, produced through a modified Delphi process, reflects our current recommendations for the diagnosis and management of CD in India. The consensus statements are intended to serve as a reference...

Spectrum and antibiotic sensitivity of bacteria contaminating the upper gut in patients with malabsorption syndrome from the tropics

, performed all microbiological works and analyzed and drafted the manuscript. Uday C Ghoshal designed the study, participated in clinical and endoscopic works and helped the first author in analyzing the data

Gastric adenocarcinoma in a patient re-infected with H. pylori after regression of MALT lymphoma with successful anti-H. pylori therapy and gastric resection: a case report

Background Helicobacter pylori (H. pylori) has been etiologically linked with primary gastric lymphoma (PGL) and gastric carcinoma (GC). There are a few reports of occurrence of both diseases in the same patient with H. pylori infection. Case presentation We report a patient with PGL in whom the tumor regressed after surgical resection combined with eradication of H. pylori...