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Dietary and genetic risk scores and incidence of type 2 diabetes

BackgroundBoth lifestyle and genetic predisposition determine the development of type 2 diabetes (T2D), and studies have indicated interactions between specific dietary components and individual genetic variants. However, it is unclear whether the importance of overall dietary habits, including T2D-related food intakes, differs depending on genetic predisposition to T2D. We...

A prospective study of dietary and supplemental zinc intake and risk of type 2 diabetes depending on genetic variation in SLC30A8

Ericson 0 Marju Orho-Melander 0 0 Diabetes and Cardiovascular Disease - Genetic Epidemiology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Clinical Research

Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes

Background TCF7L2 is a central transcription factor in the canonical wingless-type MMTV integration site (WNT) signaling pathway, and genetic variants in TCF7L2 have been found to interact with dietary fiber intake on type 2 diabetes risk. Here, we investigate whether other type 2 diabetes genes could be involved in the WNT signaling pathway and whether variants in such genes...

Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort

Background By taking diet quality into account, we may clarify the relationship between genetically elevated triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C), and better understand the inconsistent results regarding genetically elevated high-density lipoprotein-cholesterol (HDL-C), and cardiovascular disease (CVD) risk. Methods We included 24,799 participants...

Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort

Objective Although cancer promotes inflammation, the role of inflammation in tumor-genesis is less well established. The aim was to examine if low-grade inflammation is related to post-menopausal breast cancer risk, and if obesity modifies this association. Methods In the Malmö Diet and Cancer cohort, a nested case-control study was defined among 8,513 women free of cancer and...

The chromosome 9p21 variant interacts with vegetable and wine intake to influence the risk of cardiovascular disease: a population based cohort study

Background Chromosome 9p21 variants are associated with cardiovascular disease (CVD) but not with any of its known risk markers. However, recent studies have suggested that the risk associated with 9p21 variation is modified by a prudent dietary pattern and smoking. We tested if the increased risk of CVD by the 9p21 single nucleotide polymorphism rs4977574 is modified by intakes...

The Association between Carbohydrate-Rich Foods and Risk of Cardiovascular Disease Is Not Modified by Genetic Susceptibility to Dyslipidemia as Determined by 80 Validated Variants

Background It is still unclear whether carbohydrate consumption is associated with cardiovascular disease (CVD) risk. Genetic susceptibility might modify the associations between dietary intakes and disease risk. Objectives The aim was to examine the association between the consumption of carbohydrate-rich foods (vegetables, fruits and berries, juice, potatoes, whole grains...

The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels

responsibility for the final contents of the paper. Conflict of interest Ivana A. Stojkovic, Ulrika Ericson, Gull Rukh, Martin Riddestrale, Stefano Romeo and Marju Orho-Melander declare that they have no

Genetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmö Diet and Cancer Study

Gene–environment interactions need to be studied to better understand the obesity. We aimed at determining whether genetic susceptibility to obesity associates with diet intake levels and whether diet intakes modify the genetic susceptibility. In 29,480 subjects of the population-based Malmö Diet and Cancer Study (MDCS), we first assessed association between 16 genome-wide...

Dietary Fiber and Saturated Fat Intake Associations with Cardiovascular Disease Differ by Sex in the Malmö Diet and Cancer Cohort: A Prospective Study

Background The aim of the study was to examine associations between intake of macronutrients and dietary fiber and incident ischemic cardiovascular disease (iCVD) in men and women. Methods We used data from 8,139 male and 12,535 female participants (aged 44–73 y) of the Swedish population-based Malmö Diet and Cancer cohort. The participants were without history of CVD and...

Plant foods and oestrogen receptor α- and β-defined breast cancer: observations from the Malmö Diet and Cancer cohort

The associations between plant foods and breast cancer incidence are inconsistent. The objective of this study was to examine prospectively the association between dietary fibre, plant foods and breast cancer, especially the association between plant food intake and oestrogen receptor (ER) α- and β-defined breast cancer. Among women without prevalent cancer from the population...

Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study

Background Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of five potentially modifiable lifestyle factors � healthy weight, physical activity...

Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry

Rukh Stephen Rich Lisanne Booij Maria Dmitriou Erika Ax Olli Raitakari Kenneth Mukamal Satu Männistö Göran Hallmans Antti Jula Ulrika Ericson David R. Jacobs Jr Frank J. A. Van Rooij Panos Deloukas Per

Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort

Cardiovascular Disease, Genetic Epidemiology, Department of Clinical Sciences, Lund University, Malmö, Sweden (Emily Sonestedt, Ulrika Ericson); and School of Public Health, Imperial College, London, United

Nutrient Patterns and Their Food Sources in an International Study Setting: Report from the EPIC Study

Background Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses. Methodology/Principal Findings We identified nutrient patterns from food frequency questionnaires (FFQ) in the European Prospective...

Fruit and Vegetable Consumption and Mortality: European Prospective Investigation Into Cancer and Nutrition

Sonestedt, Ulrika Ericson, Lena Maria Nilsson, Kay-Tee Khaw, Nicholas J. Wareham, Timothy J. Key, Francesca L. Crowe, Isabelle Romieu, Marc J. Gunter, Valentina Gallo, Kim Overvad, Elio Riboli, and H. Bas ... , Malm, Sweden (Emily Sonestedt, Ulrika Ericson); Department of Public Health and Clinical Medicine, Nutrition Research, Ume University, Ume, Sweden (Lena Maria Nilsson); Department of Public Health and

Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry

Ericson Robert W. Koivula Audrey Y. Chu Lynda M. Rose Andrea Ganna Qibin Qi Alena Stanc a kova Camilla H. Sandholt Cathy E. Elks Gary Curhan Majken K. Jensen Rulla M. Tamimi Kristine H. Allin Torben

Dietary Fibre Intake and Risks of Cancers of the Colon and Rectum in the European Prospective Investigation into Cancer and Nutrition (EPIC)

. Peeters Anette Hjartaker Dagrun Engeset Carlos A. Gonza lez Maria-Jose Sa nchez Miren Dorronsoro Carmen Navarro Eva Ardanaz Jose R. Quiro s Emily Sonestedt Ulrika Ericson Lena Nilsson Richard Palmqvist Kay

Meta-Analysis Investigating Associations Between Healthy Diet and Fasting Glucose and Insulin Levels and Modification by Loci Associated With Glucose Homeostasis in Data From 15 Cohorts

Medicine, Lund University, Malmö, Sweden (Frida Renstrom, Ulrika Ericson, Emily Sonestedt, Marju Orho-Melander, Paul W. Franks); Department of Public Health and Clinical Medicine, Umeå University Hospital ... , Andrea Ganna, Denise K. Houston, Stavroula Kanoni, Vera Mikkilä, Ani Manichaikul, Ioanna Ntalla, Frida Renström, Emily Sonestedt, Frank J. A. van Rooij, Stefania Bandinelli, Lawrence de Koning, Ulrika