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Search: authors:"Umut Ozcan"

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Potential for therapeutic manipulation of the UPR in disease

Sang Won Park Umut Ozcan Abbreviations ER UPR ERAD PERK 0 ) Division of Endocrinology, Boston Children's Hospital, Harvard Medical School , Boston, MA, USA Increased endoplasmic reticulum (ER

Melanin Concentrating Hormone Is a Novel Regulator of Islet Function and Growth

Melanin concentrating hormone (MCH) is a hypothalamic neuropeptide known to play a critical role in energy balance. We have previously reported that overexpression of MCH is associated with mild obesity. In addition, mice have substantial hyperinsulinemia and islet hyperplasia that is out of proportion with their degree of obesity. In this study, we further explored the role of...