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Search: authors:"Ute Schöber"

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Occurrence of the human tumor-specific antigen structure Galβ1-3GalNAcα- (Thomsen–Friedenreich) and related structures on gut bacteria: Prevalence, immunochemical analysis and structural confirmation

The Thomsen–Friedenreich antigen (TF; CD176, Galβ1-3GalNAcα-) is a tumor-specific carbohydrate antigen and a promising therapeutic target. Antibodies that react with this antigen are frequently found in the sera of healthy adults and are assumed to play a role in cancer immunosurveillance. In this study, we examined the occurrence of α-anomeric TF (TFα) on a large variety of...